A four-component, one-pot synthesis of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamides

A new, one-pot, four-component reaction for the synthesis of a novel class of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamide derivatives starting from readily available inputs including aliphatic or aromatic amines, diketene, aromatic aldehydes, and 2-aminopyridines in the presence of a catalytic amount of p-toluenesulfonic acid under mild reaction conditions and in good yields at ambient temperature is described.     

Relativistic Morse Potential and Tensor Interaction

In this paper, by applying the Pekeris approximation, we present solutions of the Dirac equation for the Morse potential including a Coulomb-like tensor potential with arbitrary spin-orbit coupling number κ under spin and pseudospin symmetry limits. The generalized parametric Nikiforov–Uvarov method is used to obtain energy eigenvalues and corresponding eigenfunctions in their closed forms. We show that tensor interaction removes degeneracies between spin and pseudospin doublets. Some numerical results are given, too.     

Synthesis of a C-linked glycosylated thymine-based PNA monomer and its incorporation into a PNA oligomer

Backbone modification of peptide nucleic acids (PNAs) by glycosylation has been shown to enhance selective biodistribution and cellular targeting of PNA oligomers based on sugar and cell surface lectin interactions. Here we report the synthesis of a new backbone-glycosylated thymine-based PNA monomer (T(gal)). The sugar residue was attached to the backbone of PNA via a stable carbon-carbon linkage between the sugar and the PNA monomers. Also, incorporation of the modified monomer into a PNA decamer (H-Ala(gal)-G-G-G-T(gal)-C-A-G-C-T(gal)-T-Lys-NH2) was successfully performed. Melting temperature (UV-Tm) of the modified PNA against the complementary DNA was only slightly lower than unmodified PNA.     

Exact Spin and Pseudospin Symmetry Solutions of the Dirac Equation for Mie-Type Potential Including a Coulomb-like Tensor Potential

We solve the Dirac equation for Mie-type potential including a Coulomb-like tensor potential under spin and pseudospin symmetry limits with arbitrary spin–orbit coupling quantum number κ. The Nikiforov–Uvarov method is used to obtain analytical solutions of the Dirac equation. Since it is only the wave functions which are obtained in a closed exact form; as for the eigenvalues, only the eigenvalue equations have been given and they have been solved numerically. It is also shown that the degeneracy between spin doublets and pseudospin doublets is removed by tensor interaction.     

含吡啶的大环席夫碱锰（Ⅱ）配合物：合成、表征及抗菌性质

在Mn（Ⅱ）模板作用下,2,6-diacetylpyridine（DAP）及合适链状胺化合物通过[1+1]环缩合反应,合成了3个大环席夫碱配合物,并进行了红外、元素分析、质谱及电导率等表征及研究。测得了配合物[MnL¹（CH₃CN）]（ClO₄）₂的晶体结构,中心离子呈现出稍微扭曲的五角锥配位构型。研究了配合物对S.aureus（ATCC6633）,B.cereus（ATCC7064）,C.xerosis（ATCC373）（gram-positive bacterial strains）,E.coli（PTCC10009）,K.pneuomoniae（MTCC109）,and P.vulgaris（lio）（gram-negative bacterial strains）的抗菌活性。结果显示[MnL³]（ClO₄）₂抗菌活性明显优于[MnL¹（CH₃CN）]（ClO₄）₂ and [MnL²]（ClO₄）₂。在25℃条件下0.1mol·L^-1 KCl溶液中,通过电位计量法测定了化合物的质子化常数。     

Spin and pseudospin symmetric Dirac particles in the field of Tietz-Hua potential including Coulomb tensor interaction＊

Approximate analytical solutions of the Dirac equation for Tietz-Hua (TH) potential including Coulomb-like tensor (CLT) potential with arbitrary spin-orbit quantum number κ are obtained within the Pekeris approximation scheme to deal with the spin-orbit coupling terms κ(κ± 1)r-2 . Under the exact spin and pseudospin symmetric limitation, bound state energy eigenvalues and associated unnormalized two-component wave functions of the Dirac particle in the field of both attractive and repulsive TH potential with tensor potential are found using the parametric Nikiforov-Uvarov (NU) method. The cases of the Morse oscillator with tensor potential, the generalized Morse oscillator with tensor potential, and the non-relativistic limits have been investigated.     

Spin-1/2 Particle in Scalar-Vector-Pseudoscalar Spatially Dependent Mass Coulomb Fields: 1 + 1 Dimensions

In this letter, we present exact solutions of the Dirac equation with the mixed scalar-vector-pseudoscalar spatially dependent mass Coulomb potential under spin and pseudospin (p-spin) symmetry limits in 1+1 dimensions.     

Protein Engineering of Bacillus thermocatenulatus Lipase via Deletion of the α5 Helix

Lipases from Bacillus thermocatenulatus are a member of superfamily of α/β hydrolase, but there are structural differences between them. In this work, we focused on the α5 helix of B. thermocatenulatus lipase (BTL2) which is absent in canonical α/β hydrolase fold. In silico study showed that the α5 helix is a region that causes disorder in BTL2 protein. So, the α5 helix (residues 131 to 150) has been deleted from the B. thermocatenulatus lipase gene (BTL2) and the remain (Δα5-BTL2) has been expressed in Pichia pastoris yeast. The α5 deletion results in increase of enzyme-specific activity in the presence of tributyrin, tricaproin, tricaprylin, tricaprin, trilaurin, and olive oil (C18) substrates by 1.4-, 1.7-, 2.0-, 1.2-, 1.75-, and 1.95-fold, respectively. Also, deletion leads to increase in enzyme activity in different temperatures and pHs, whereas it did not significantly affect on enzyme activity in the presence of organic solvents, metal ions, and detergents.