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61.
Tayel A. Al Hujran Mousa K. Magharbeh Almeqdad Y. Habashneh Rasha S. Al-Dmour Ashraf Aboelela Hesham M. Tawfeek 《Molecules (Basel, Switzerland)》2022,27(14)
The study aims to assess the interaction between fluconazole and sulfonatocalix[4]naphthalene towards enhancing its dissolution performance and antimycotic activity. A solubility study was carried out at different pH conditions, and the results revealed the formation of a 1:1 molar ratio fluconazole-sulfonatocalix[4]naphthalene inclusion complex with an AL type phase solubility diagrams. The solid powder systems of fluconazole-sulfonatocalix[4]naphthalene were prepared using kneaded and co-evaporation techniques and physical mixtures. DCS, PXRD, TGA-DTG, FT-IR, and in vitro dissolution performance characterize the prepared systems. According to physicochemical characterization, the co-evaporation approach produces an amorphous inclusion complex of the drug inside the cavity of sulfonatocalix[4]naphthalene. The co-evaporate product significantly increased the drug dissolution rate up to 93 ± 1.77% within 10 min, unlike other prepared solid powders. The antimycotic activity showed an increase substantially (p ≤ 0.05, t-test) antimycotic activity of fluconazole co-evaporate mixture with sulfonatocalix[4]naphthalene compared with fluconazole alone against clinical strains of Candida albicans and Candida glabrata. In conclusion, sulfonatocalix[4]naphthalene could be considered an efficient complexing agent for fluconazole to enhance its aqueous solubility, dissolution performance, and antimycotic activity. 相似文献
62.
Mohamad M.E. Shakdofa Hanan A. Mousa Ahmed M.A. Elseidy Ammar A. Labib Mamdouh M. Ali Amira S. Abd‐El‐All 《应用有机金属化学》2018,32(1)
Thiosemicarbazone ligand, 2‐((4,9‐dimethoxy‐5‐oxo‐5H‐furo[3,2‐g]chromen‐6‐yl)methylene) hydrazinecarbothioamide and its Cd(II), Cu(II), Zn(II), Ni(II), Co(II), VO(II), and Mn(II) complexes have been prepared and characterized by various spectroscopic and analytical techniques. Complexes molar conductance measurements displayed that all complexes (2–8) are non‐electrolyte. With general composition [M(H3L)(CH3COO)2H2O].nH2O, where M = Cd(II), Cu(II), Zn(II), Ni(II), Co(II) and Mn(II) while complex (8) has [VO(H3L)(SO4)H2O].2H2O formula. Based on analytical and spectral measurements, the octahedral or distorted octahedral geometries suggested for complexes. Ligand and complexes anti‐proliferative activities were assessed against three various human tumor cell lines including breast cancer (MCF‐7), liver cancer (HepG2) and lung cancer (A549) using SRB fluorometric assay and cis‐platin as positive control. The anti‐proliferative activity result indicated that the ligand and its complexes have considerable anti‐proliferative activity analogous to that of ordinarily utilized anti‐cancer drug (cis‐platin). They do their anti‐cancer activities by modifying free radical's generation via raising the superoxide dismutase activity and depletion of intracellular reduced glutathione level, catalase, glutathione peroxidase activities, escorted by highly generation of hydrogen peroxide, nitric oxide and other free radicals leading to tumor cells death, as monitoring by decreasing the protein and nucleic acids synthesis. 相似文献
63.
Sedaghat Esmat Rostami Abbas Ali Ghaemy Mousa Rostami Ali 《Journal of Thermal Analysis and Calorimetry》2019,136(2):759-769
Journal of Thermal Analysis and Calorimetry - In this study, we synthesized a biodegradable nanocomposite containing starch, polyvinyl alcohol (PVA), and graphene oxide (GO). The non-isothermal... 相似文献
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A series of compounds 3a-d,i-n with two or three 1,2,3-thiadiazole rings, useful for photocrosslinking processes, was prepared from the di- or triketones 1a-d,i-n via the corresponding hydrazones 2a-d,i-n by applying the Hurd-Mori method. A special synthetic sequence, 1e, 2e, 3e, 3f/3g , was elaborated for the olefinic system 3h. 相似文献
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Swartz M Abrams GS Adolphsen CE Averill D Ballam J Barish BC Barklow T Barnett BA Bartelt J Bethke S Blockus D Bonvicini G Boyarski A Brabson B Breakstone A Bulos F Burchat PR Burke DL Cence RJ Chapman J Chmeissani M Cords D Coupal DP Dauncey P DeStaebler HC Dorfan DE Dorfan JM Drewer DC Elia R Feldman GJ Fernandes D Field RC Ford WT Fordham C Frey R Fujino D Gan KK Gatto C Gero E Gidal G Glanzman T Goldhaber G Gomez Cadenas JJ Gratta G Grindhammer G Grosse-Wiesmann P Hanson G Harr R Harral B 《Physical review letters》1990,64(24):2877-2880
69.
Kral JF Abrams GS Adolphsen CE Averill D Ballam J Barish BC Barklow T Barnett BA Bartelt J Bethke S Blockus D Bonvicini G Boyarski A Brabson B Breakstone A Bulos F Burchat PR Burke DL Cence RJ Chapman J Chmeissani M Cords D Coupal DP Dauncey P DeStaebler HC Dorfan DE Dorfan JM Drewer DC Elia R Feldman GJ Fernandes D Field RC Ford WT Fordham C Frey R Fujino D Gan KK Gatto C Gero E Gidal G Glanzman T Goldhaber G Gomez Cadenas JJ Gratta G Grindhammer G Grosse-Wiesmann P Hanson G Harr R Harral B 《Physical review letters》1990,64(11):1211-1214
70.
Burchat PR King M Abrams GS Adolphsen CE Averill D Ballam J Barish BC Barklow T Barnett BA Bartelt J Bethke S Blockus D Bonvicini G Boyarski A Brabson B Breakstone A Bulos F Burke DL Cence RJ Chapman J Chmeissani M Cords D Coupal DP Dauncey P DeStaebler HC Dorfan DE Dorfan JM Drewer DC Elia R Feldman GJ Fernandes D Field RC Ford WT Fordham C Frey R Fujino D Gan KK Gatto C Gero E Gidal G Glanzman T Goldhaber G Gomez Cadenas JJ Gratta G Grindhammer G Grosse-Wiesmann P Hanson G Harr R Harral B 《Physical review D: Particles and fields》1990,41(11):3542-3545