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81.
Le TT Chau NT Nguyen TT Brien J Thai TT Nourry A Castanet AS Nguyen KP Mortier J 《The Journal of organic chemistry》2011,76(2):601-608
The metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid (8) affording trianion 6 is presented and applied to the regioselective efficient construction of a series of 5,5'-didesisopropyl-5,5'-dialkylapogossypol derivatives 3 that are potent pan-active inhibitors of antiapoptotic Bcl-2 family proteins. 相似文献
82.
Oscar Moradei Cecile du Mortier Alicia Fernández Cirelli Joachim Thiem 《Journal of carbohydrate chemistry》2013,32(4-5):525-532
Abstract The stereospecific synthesis of methyl 3-O-benzoyl-6-O-(tert-butyldiphenylsilyl)-2-deoxy-α-d-erythro-hexopyranosid-4-ulose (5) - a Thromboxane B2 (TXB2) precursor -starting from D-galactose is described. Facile and established methods including selective benzoylation, oxidation-elimination and a stereocontrolled hydrogenation (Pd/charcoal) were employed effectively. 相似文献
83.
Anne-Sophie Castanet Jean-Baptiste Véron Asish De Jacques Mortier 《Tetrahedron》2008,64(15):3331-3336
The new sequential stereoselective synthesis of diversely substituted 9H-fluoren-9-ones by ortho-lithiation/Bu3SnCl quench of unprotected benzoic acids followed by Stille cross-coupling reaction and remote metalation is reported. 相似文献
84.
Aissaoui R Nourry A Coquel A Dao TT Derdour A Helesbeux JJ Duval O Castanet AS Mortier J 《The Journal of organic chemistry》2012,77(1):718-724
Substitution of an ortho-fluoro or methoxy group in 1- and 2-naphthoic acids furnishing substituted naphthoic acids occurs in good to excellent yields upon reaction with alkyl/vinyl/aryl organolithium and Grignard reagents, in the absence of a metal catalyst without the need to protect the carboxyl (CO(2)H) group. This novel nucleophilic aromatic substitution is presumed to proceed via a precoordination of the organometallic with the substrate, followed by an addition/elimination. 相似文献
85.
[reaction: see text] By treatment with s-BuLi/TMEDA at -78 degrees C, unprotected 2-methoxybenzoic acid is deprotonated exclusively in the position ortho to the carboxylate. A reversal of regioselectivity is observed when the acid is treated with n-BuLi/t-BuOK. These results are of general utility for the one-pot preparation of a variety of very simple 3- and 6-substituted 2-methoxybenzoic acids that are not easily accessible by conventional means. The potential usefulness of the method is demonstrated by the expedient synthesis of lunularic acid. 相似文献
86.
This work describes the development of a straightforward method for the determination of free docetaxel and paclitaxel in plasma. The separation of bound and unbound drug was performed with ultrafiltration. Different ultrafiltration devices were evaluated, especially regarding non-specific binding to the device. The most appropriate device for this application was selected and a procedure to counteract non-specific binding to the ultrafiltrate collection cup was developed. This consisted of a wash procedure with methyl t-butyl ether. A liquid/liquid extraction with methyl t-butyl ether was performed and samples were analysed with a previously developed liquid chromatography-tandem mass spectrometry procedure. The method used a Merck Purospher Star RP-18 column (55 mm x 2.0 mm, 3-microm particle size) and electrospray in the positive mode. A triple quadrupole instrument was used to monitor MRM transitions. Small modifications to this procedure were made to ensure adequate sensitivity. Within- and between-day reproducibility did not exceed 15% and accuracy ranged between 94.4 and 102.5%. The calibration range of the method was from 0.4 to 100 ng/ml both for paclitaxel and docetaxel. Finally, a fast and relatively simple method could be developed. 相似文献
87.
Europium-doped lead germanate and lead fluorogermanate glasses are studied by using differential thermal analysis, X-ray diffraction, photoluminescence and fluorescence lifetimes measurements of the 5Dj, j = 0, 1, 2 levels. PbF2 addition increases the thermal stability of the lead germanate glass, while Eu3+ ions promote the crystallization of β-PbF2:Eu3+ nano-crystals embedded in a glassy matrix. In the lead fluorogermanate glasses, Eu3+ ions exhibit a strong affinity for F− ions although oxygen ions are much more numerous. It appears that luminescence concentration quenching is not important, while cross relaxation is very efficient in the glasses. The results allow to propose for these glasses a molecular model in which small fluorine rich island, incorporating the Eu3+ ions in low symmetry sites, are separated from each other by chains of germanate (GeO4)4− ions linked together. 相似文献
88.
M. Mortier J. Y. Gesland M. Rousseau M. A. Pimenta L. O. Ladeira J. C. Machado Da Silva G. A. Barbosa 《Journal of Raman spectroscopy : JRS》1991,22(7):393-396
Single crystals of the fluoride compound KY3F10 (Oh5) were studied by Raman scattering from 40 to 950 K. Group theory analysis predicts 3A1g + 4Eg + 6F2g Raman-active modes, but the experimental spectra show two F2g modes missing. Over the whole temperature range the frequency shifts are negligible whereas the line widths show a strong increase with temperature. Both reversible and irreversible line width behaviour are exhibited for different temperature runs, indicating a complex microscopic phenomenon underlying the creation of defects responsible for these line widths and their interaction with the different phonon modes. An approximate activation energy for defect creation of ΔE ≈︁ 0.3 eV can be obtained from the temperature behaviour of the line widths. This activation energy may be connected with the high-temperature ionic conduction mentioned previously for this crystal. 相似文献