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71.
The kinetics of precipitation reactions with110AgNO3 of some di (β-chlorethyl) amine derivates and hydrochlorides with esters of N-(p-aminobenzoyl)-L-aspartic acid as carriers in dimethylformamide-water mixture, were studied. The rate constants of these reactions were of the order of 10?4 1 · mol?1 · min?1. The concentrations of the corresponding hydrochloride solutions were measured by radiometric titration with110AgNO3 solution of given concentration. 相似文献
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Csorna SE Garren L Mestayer MD Panvini RS Yi X Alam MS Avery P Bebek C Berkelman K Cassel DG Copie T DeSalvo R DeWire JW Ehrlich R Ferguson T Galik R Gilchriese MG Gittelman B Halling M Hartill DL Holzner S Ito M Kadaswamy J Kreinick DL Kubota Y Mistry NB Nordberg E Ogg M Peterson D Perticone D Read K Silverman A Stein PC Stone S Kezun X Sadoff AJ Giles RT Hassard J Hempstead M Kinoshita K McKay WW Pipkin FM Wilson R Haas P Jensen T Kagan H Kass R Behrends S Gentile T Guida JM Guida JA Morrow F 《Physical review letters》1985,54(17):1894-1897
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Huiyong Yin Brian E. Cox Wei Liu Ned A. Porter Jason D. Morrow Ginger L. Milne 《Journal of mass spectrometry : JMS》2009,44(5):672-680
Free radical‐induced oxidation products of polyunsaturated fatty acids esterified to phospholipids have been implicated in a number of human diseases including atherosclerosis and neurodegenerative diseases. Some of these phospholipid oxidation products have potent biological activities and likely contribute to human pathophysiological conditions. Oxidation products have also been used as markers of oxidative stress in vivo. Identification and quantification of phospholipid oxidation products are often performed by analyzing the oxidized free fatty acid moieties after hydrolysis from the phospholipids head groups by gas chromatography–mass spectrometry (GC–MS) or liquid chromatography–mass spectrometry (LC–MS). We now describe the definitive identification of intact oxidized products of glycerophospholipids including glycerophosphatidylcholine (GPC), glycerophosphatidylethanolamine (GPE), and glycerophosphatidylserine (GPS) in vitro and in vivo using iontrap MS. For these analyses, the negative ions of the oxidation products of phospholipids are fragmented to MSn and unequivocal structural characterization is obtained based on collision‐induced dissociation (CID) of the sn‐2 carboxylate ion. This technique overcomes the need to hydrolyze fatty acids from phospholipids in the analysis. The method has been used to identify a number of oxidation products of glycerophospholipids including hydroxyeicosatetraenoates (HETEs) and isoprostanes (IsoPs) esterified to different classes of glycerophospholipids in vitro and in vivo. These studies thus provide a new approach to identify the intact oxidation products of glycerolphospholipids. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
77.
Allan L Leith JL Papakosta M Morrow JA Irving NG McFerran BW Clark AG 《Combinatorial chemistry & high throughput screening》2006,9(1):9-14
The glycine transporter (GlyT-1b) is a Na(+)/Cl(-)-dependent electrogenic transporter which mediates the rapid re-uptake of glycine from the synaptic cleft. Based on its tissue distribution, GlyT-1 has been suggested to co-localise with the NMDA receptor where it may modulate the concentration of glycine at its co-agonist binding site. This data has led to GlyT-1 inhibitors being proposed as targets for disorders such as schizophrenia and cognitive dysfunction. Radiolabelled uptake assays (e.g. [(3)H]glycine) have been traditionally used in compound screening to identify glycine transporter inhibitors. While such an assay format is useful for testing limited numbers of compounds, the identification of novel glycine uptake inhibitors requires a functional assay compatible with high-throughput screening (HTS) of large compound libraries. Here, the authors present the development of a novel homogenous cell-based assay using the FLIPR membrane potential blue dye (Molecular Devices) and FLEXstation. Pharmacological data for the GlyT-1 inhibitors Org 24598 and ALX 5407 obtained using this novel electrogenic assay correlated well with the conventional [(3)H]-glycine uptake assay format. Furthermore, the assay has been successfully miniaturised using FLIPR(3) and therefore has the potential to be used for high-throughput screening. 相似文献
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Ammar R Ball S Baringer P Coppage D Copty N Davis R Hancock N Kelly M Kwak N Lam H Kubota Y Lattery M Nelson JK Patton S Perticone D Poling R Savinov V Schrenk S Wang R Alam MS Kim IJ Nemati B O'Neill JJ Severini H Sun CR Zoeller MM Crawford G Daubenmeir M Fulton R Fujino D Gan KK Honscheid K Kagan H Kass R Lee J Malchow R Morrow F Skovpen Y Sung M White C Whitmore J Wilson P Butler F Fu X Kalbfleisch G Lambrecht M Ross WR Skubic P Snow J Wang PL Wood M Bortoletto D Brown DN Fast J McIlwain RL 《Physical review letters》1993,71(5):674-678
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Selen M Sadoff AJ Ammar R Ball S Baringer P Coppage D Copty N Davis R Hancock N Kelly M Kwak N Lam H Kubota Y Lattery M Nelson JK Patton S Perticone D Poling R Savinov V Schrenk S Wang R Alam MS Kim IJ Nemati B O'Neill JJ Severini H Sun CR Zoeller MM Crawford G Daubenmeir CM Fulton R Fujino D Gan KK Honscheid K Kagan H Kass R Lee J Malchow R Morrow F Skovpen Y Sung M White C Whitmore J Wilson P Butler F Fu X Kalbfleisch G Lambrecht M Ross WR Skubic P Snow J Wang PL Wood M Bortoletto D Brown DN 《Physical review letters》1993,71(13):1973-1977