Studies on proton pump inhibitors. II. Synthesis and antiulcer activity of 8-[(2-benzimidazolyl)sulfinylmethyl]-1,2,3,4-tetrahydroquinolines and related compounds

Many 8-[(2-benzimidazolyl)sulfinylmethyl]-1,2,3,4-tetrahydroquinolin e derivatives were synthesized and tested for their (H+ + K+)adenosine triphosphatase (ATPase)-inhibitory and antisecretory activities against histamine-induced gastric acid secretion in rats. These sulfinyl compounds were synthesized by the oxidation of the corresponding sulfides, which were obtained from the reaction of 8-chloromethyl-1,2,3,4-tetrahydroquinolines and 2-mercaptobenzimidazoles in the presence of potassium carbonate. All compounds tested were potent inhibitors of (H+ + K+)ATPase. Most of the compounds showed antisecretory activity. Among them, 8-[(2-benzimidazolyl)sulfinylmethyl]-1-ethyl-1,2,3,4-tetrahydro quinoline (IXa) was found to have the most potent activity. The structure-activity relationships are discussed.     

Superexchange-coupled Cr3+ luminescence in polynuclear complex salts

We report the luminescence of a series of bi-, tri-, and quadrinuclear complex salts of Cr³⁺ ions in the temperature range of 4–77°K. The complex compounds studied are of the Werner type. Emission spectra are interpreted on the basis of the Heisenberg spin-spin coupling model of Cr³⁺ pairs derived from magnetic susceptibility data.     

Electronic density of states for the linear random binary alloy in the three-site coherent potential approximation

Morita and Chen's scheme of generalizing the coherent potential approximation in which the diagonal and off-diagonal randomness are included, is applied to the calculation of the electronic density of states for the linear random binary alloy. The result obtained in the three-site coherent potential approximation is reported.