13C NMR spectra of thieno[2,3-b][1,5]benzodiazepine neuroleptics

The ¹³C NMR spectra of five thieno[2,3-b][1,5]benzodiazepines and two related benzodiazepinones have been recorded at 22.64 MHz using broad band and off-resonance proton decoupling techniques. Spectral interpretation is facilitated by the presence of one (or more) fluorine substituents in the benzo-ring.     

A Helmholtz pressure equation method for the calculation of unsteady incompressibl eviscous flows

A time-implicit numerical method for solving unsteady incompressible viscous flow problems is introduced. The method is based on introducing intermediate compressibility into a projection scheme to obtain a Helmholtz equation for a pressure-type variable. The intermediate compressibility increases the diagonal dominance of the discretized pressure equation so that the Helmholtz pressure equation is relatively easy to solve numerically. The Helmholtz pressure equation provides an iterative method for satisfying the continuity equation for time-implicit Navier–Stokes algorithms. An iterative scheme is used to simultaneously satisfy, within a given tolerance, the velocity divergence-free condition and momentum equations at each time step. Collocated primitive variables on a non-staggered finite difference mesh are used. The method is applied to an unsteady Taylor problem and unsteady laminar flow past a circular cylinder.     

Instabilities of cylindrical bubble clusters

The European Physical Journal E - Small bubbles in an experimental two-dimensional foam between glass plates regularly undergo a three-dimensional instability as the small bubbles shrink under...     

The effect of auditory feedback on phonation threshold pressure measurement

The effect of auditory feedback on phonation threshold pressure (Pth) measurement was investigated in 14 females with normal, untrained voices. Two measurement systems (Glottal Enterprises MS 100--circumferentially vented mask and Kay Elemetrics Aerophone II--non-circumferentially vented mask) were examined under three conditions: (1) masked, (2) no mask, and (3) masked with enhanced auditory feedback-acoustic signal placed at ears through headphones. Masked with enhanced auditory feedback, in addition to subject training, significantly lowered Pth values regardless of mask design. The amount of auditory feedback provided by different mask designs was investigated and revealed a significant difference. Clinical significance of different auditory feedback levels provided by the two mask designs was investigated. Direct comparison of the mean values between systems was not possible because of each system's design and calibration. Comparisons were accomplished by subtracting means of select-paired conditions (masked/no mask; masked/masked plus masked with enhanced auditory feedback) within each system and then comparing these difference scores from the same paired conditions between each system. No clinical significance in difference scores was revealed because of varying amounts of auditory feedback provided by the masks. Results support the use of enhanced auditory feedback, in addition to subject training, when measuring Pth.     

PDAs and Lab Works—A New Way to Make Chemical Measurements

Computer-controlled data acquisition is rapidly becoming the rule rather than the exception in general chemistry laboratories. The LabWorks learning system is one of many computer-controlled data acquisition interfaces that allow students to quickly obtain and analyze chemistry data. This article explains how communication is established between a personal digital assistant (PDA) and the LabWorks interface. This project continues work previously accomplished using an HP 48 calculator to communicate with the LabWorks interface. The PDA has more computing power, more storage ability, and the Windows CE operating system provides a more user-friendly interface than the handheld graphing calculator. Sample experimental data is provided as an example of how this LabWorks/Palm PC combination can be applied to inexpensively enhance laboratory learning.     

Some Models for a Hierarchical Manpower System

This paper is an extension of previous work which described a model for a hierarchical manpower system with two grades. The model is first extended to a system with several grades, and then to a system with several types of entrant or in which the type of entrant has changed over time. Finally, a calculation is described which can be used to determine the best mix of qualifications amongst the entrants.     

Synthesis and in vivo activity of some porphyrindione derivatives with potential in photodynamic therapy

A number of synthetic bacteriochlorins were prepared from porphyrindiones. The potential of these compounds as sensitizers for photodynamic therapy was examined using the FANFT-induced urothelial cell carcinoma (AY-27) transplanted into rats. In a number of cases, tumor regression was significant following treatment with both drug and light.     

Modifications in the alditol acetate method for analysis of muramic acid and other neutral and amino sugars by capillary gas chromatography-mass spectrometry with selected ion monitoring

Two alditol acetate methods for the gas chromatographic (GC) analysis of neutral and amino sugars were compared. Following sodium borohydride reduction, one method uses methylimidazole as an acetylation catalyst without prior removal of water or borate salts and the other method uses sodium acetate after removal of borate and water. Depending on the acetylation conditions, muramic acid produced different derivatives. With methylimidazole, reliable derivatization of muramic acid was not possible, although other sugars derivatized reliably. With sodium acetate, all sugars tested were reproducibly derivatized. The utility of the sodium acetate method is shown by the trace GC-mass spectrometric analysis of muramic acid and rhamnose derived from bacterial peptidoglycan-polysaccharide complexes in mammalian tissue.