全文获取类型
收费全文 | 392篇 |
免费 | 5篇 |
国内免费 | 1篇 |
专业分类
化学 | 297篇 |
晶体学 | 1篇 |
力学 | 1篇 |
数学 | 54篇 |
物理学 | 45篇 |
出版年
2022年 | 3篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 5篇 |
2014年 | 6篇 |
2013年 | 12篇 |
2012年 | 6篇 |
2011年 | 12篇 |
2010年 | 8篇 |
2009年 | 7篇 |
2008年 | 12篇 |
2007年 | 15篇 |
2006年 | 16篇 |
2005年 | 23篇 |
2004年 | 20篇 |
2003年 | 10篇 |
2002年 | 18篇 |
2001年 | 4篇 |
1999年 | 8篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 3篇 |
1993年 | 5篇 |
1990年 | 9篇 |
1989年 | 5篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 7篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1978年 | 6篇 |
1977年 | 11篇 |
1976年 | 8篇 |
1975年 | 10篇 |
1974年 | 17篇 |
1973年 | 11篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1970年 | 5篇 |
1955年 | 4篇 |
1930年 | 3篇 |
1925年 | 4篇 |
1911年 | 2篇 |
1910年 | 2篇 |
1908年 | 2篇 |
1902年 | 2篇 |
排序方式: 共有398条查询结果,搜索用时 15 毫秒
391.
392.
393.
394.
Wille SM Van Hee P Neels HM Van Peteghem CH Lambert WE 《Journal of chromatography. A》2007,1176(1-2):236-245
A gas chromatographic-mass spectrometric method (GC-MS) for the simultaneous determination of the 'new' antidepressants (mirtazapine, viloxazine, venlafaxine, trazodone, citalopram, mianserin, reboxetine, fluoxetine, fluvoxamine, sertraline, maprotiline, melitracen, paroxetine) and their active metabolites (desmethylmirtazapine, O-desmethylvenlafaxine, m-chlorophenylpiperazine, desmethylcitalopram, didesmethylcitalopram, desmethylmianserin, desmethylfluoxetine, desmethylsertraline, desmethylmaprotiline) in plasma using different ionization modes was developed and validated. Sample preparation consisted of a strong cation exchange mechanism and derivatisation with heptafluorobutyrylimidazole. The GC separation was performed in 24.8 min. Identification and quantification were based on selected ion monitoring in electron (EI) and chemical ionization (CI) modes. Calibration by linear and quadratic regression for electron and chemical ionization, respectively, utilized deuterated internal standards and a weighing factor 1/x(2). Limits of quantitation were established between 5 and 12.5 ng/ml in EI and positive ionization CI (PICI), and 1 and 6.25 ng/ml in negative ionization CI (NICI). During validation stability, sensitivity, precision, accuracy, recovery, and selectivity were evaluated for each ionization mode and were demonstrated to be acceptable for most compounds. While it is clear that not all compounds can be quantitated either due to chromatographic (trazodone) or derivatisation problems (O-desmethylvenlafaxine), this method can quantitate most new antidepressants (ADs) in the therapeutic range using EI. PICI and NICI lead to higher selectivity. Moreover, NICI is of interest for small sample volumes and high sensitivity requirements. This paper draws the attention to the pros and cons of the different ionization modes in the GC-MS analysis of these antidepressants in plasma. 相似文献
395.
Yasmeen F Szmigielski R Vermeylen R Gómez-González Y Surratt JD Chan AW Seinfeld JH Maenhaut W Claeys M 《Journal of mass spectrometry : JMS》2011,46(4):425-442
In this study, we present liquid chromatographic and mass spectral data for predominant terpenoic acids formed through oxidation of α-pinene, β-pinene, d-limonene, and Δ(3)-carene that occur in fine forest aerosol from K-puszta, Hungary, a rural site with coniferous vegetation. Characterization of these secondary organic aerosol tracers in fine ambient aerosol is important because it allows one to gain information on monoterpene precursors and source processes such as oxidation and aging processes. The mass spectral data were obtained using electrospray ionization in the negative ion mode, accurate mass measurements, and linear ion trap tandem mass spectrometric experiments. Emphasis is given to the mass spectrometric differentiation of isobaric terpenoic acids, such as, e.g. the molecular weight (MW) 186 terpenoic acids, cis-pinic, cis-caric, homoterpenylic, ketolimononic, and limonic acids. Other targeted isobaric terpenoic acids are the MW 184 terpenoic acids, cis-pinonic and cis-caronic acids, and the MW 204 tricarboxylic acids, 3-methyl-1,2,3-butanetricarboxylic and 3-carboxyheptanedioic acids. Fragmentation pathways are proposed to provide a rational explanation for the observed isomeric differences and/or to support the suggested tentative structures. For the completeness of the data set, data obtained for recently reported lactone-containing terpenoic acids (i.e. terpenylic and terebic acids), related or isobaric compounds (i.e. norpinic acid, diaterpenylic acid acetate, and unknown MW 188 compounds) are also included, the rationale being that other groups working on this topic could use this data compilation as a reference. 相似文献
396.
397.
Teng Wei Ng Ran Tao Willy Wei Li See Si Bei Poh Yu Zhao 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2023,135(2):e202212528
We disclose herein a catalytic borrowing hydrogen method that enables an unprecedented, economical one-pot access to enantiopure tetrahydropyridines with minimal reagent use or waste formation. This method couples a few classes of readily available substrates with commercially available 1,3-amino alcohols, and delivers the valuable tetrahydropyridines of different substitution patterns free of N-protection. Such transformations are highly challenging to achieve, as multiple redox steps need to be realized in a cascade and numerous side reactions including a facile aromatization have to be overcome. Highly diastereoselective functionalizations of tetrahydropyridines also result in a general access to enantiopure di- and tri-substituted piperidines, which ranks the topmost frequent N-heterocycle in commercial drugs. 相似文献
398.
Sedimentation of fibres and particles can be observed manifold in industrial application. In waste water treatment, the water is clarified from solid particles and fibres utilizing sedimentation. Some filtration processes use fibres as an aid to improve the filtration quality. Finally, in the paper recycling process, one tries to separate cellulose fibres from inorganic particles used as filling material or in printing colours. For all these applications, it is necessary to understand the hydrodynamic interactions between single particles as well as particle and fibre collectives. In the present paper, the sedimentation behaviour of fibres and particles is considered in detail. Mathematic modelling is used to investigate inter particle influences in detail. In particular, a method called Stokesian Dynamics is used to simulate the settling of fibres and particles. The main challenge of the modelling is the dependence of the direction of each fibre on its sedimentation velocity and the different sizes of the particles in a poly-modal particle size distribution. Additionally fibres, particles and the fluid are influencing each other in a significant manner and in a long range. Therefore, while calculating the force on a particle, one has to take into account the influences of many particles. (© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献