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131.
Daniel A. Holland‐Moritz Michael K. Wismer Benjamin F. Mann Iman Farasat Paul Devine Erik D. Guetschow Ian Mangion Christopher J. Welch Jeffrey C. Moore Shuwen Sun Robert T. Kennedy 《Angewandte Chemie (International ed. in English)》2020,59(11):4470-4477
Microfluidic droplet sorting enables the high‐throughput screening and selection of water‐in‐oil microreactors at speeds and volumes unparalleled by traditional well‐plate approaches. Most such systems sort using fluorescent reporters on modified substrates or reactions that are rarely industrially relevant. We describe a microfluidic system for high‐throughput sorting of nanoliter droplets based on direct detection using electrospray ionization mass spectrometry (ESI‐MS). Droplets are split, one portion is analyzed by ESI‐MS, and the second portion is sorted based on the MS result. Throughput of 0.7 samples s?1 is achieved with 98 % accuracy using a self‐correcting and adaptive sorting algorithm. We use the system to screen ≈15 000 samples in 6 h and demonstrate its utility by sorting 25 nL droplets containing transaminase expressed in vitro. Label‐free ESI‐MS droplet screening expands the toolbox for droplet detection and recovery, improving the applicability of droplet sorting to protein engineering, drug discovery, and diagnostic workflows. 相似文献
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C. Magron Ph. Alfaurt B. Blank L. Daudin T. Eronen M. Gerbaux J. Giovinazzo D. Gorelov S. Grévy H. Guérin J. Hakala V. S. Kolhinen J. Koponen T. Kurtukian Nieto I. D. Moore H. Penttilä I. Pohjalainen J. Reinikainen M. Reponen S. Rinta-Antila M. Roche A. de Roubin N. Smirnova B. Thomas A. Voss L. Xayavong 《The European Physical Journal A - Hadrons and Nuclei》2017,53(4):77
135.
Carlos A. Martinez Eric Keller Renzo Meijer Gerard Metselaar Gerlof Kruithof Curtis Moore Pei-Pei Kung 《Tetrahedron: Asymmetry》2010,21(19):2408-2412
An efficient four-step biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol in enantiomerically pure form is described. This compound is a key intermediate required for the preparation of PF-2341066, a potent inhibitor of c-Met/ALK that is currently in clinical development. The described synthesis was used to manufacture 6 kg of the title compound and can also be employed to produce the corresponding (1R)-enantiomer. 相似文献
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Application-specific optimization of disordered nanoporous carbons remains a formidable challenge due to the difficulty in
accurately characterizing their microstructures with current empirical methods. Using molecular simulation techniques, we
investigated the adsorptive and diffusive behavior of argon in three models of disordered nanoporous carbons. We found that
the structural and morphological differences between these models gave rise to distinct phenomenological properties. The adsorptive
behavior of argon in both the low and high pressure regimes was enhanced dramatically in the models with more crystalline
microstructures. As for dynamic properties, we found that the adsorbent’s structure and energetic topology significantly alters
the rates of diffusion as well as the characteristics of the underlying diffusion mechanisms. 相似文献
138.
In this paper, we discuss techniques by which the aeroacoustic properties of the turbulent flow in a rod-airfoil benchmark
experiment can be inferred from time-resolved PIV measurement. While acoustic measurements can be made directly using microphones,
the proposed techniques provide a means to directly link acoustic waves with specific flow events, which is invaluable in
devising noise mitigation strategies. The approaches are possible thanks to recent improvements in digital and camera technology
that can provide time-resolved measurements in air flows, necessary for the determination of unsteady flow quantities related
to aeroacoustic production. Both techniques are based on Curle’s acoustic analogy, where one is based on Lagrangian determination
of the required quantities, while the other requires all flow quantities to be converted into Fourier modes. Application of
both techniques yields results that are in reasonable agreement with microphone noise measurements for the rod-airfoil experiment. 相似文献
139.
Elucidation and identification of amino acid containing membrane lipids using liquid chromatography/high‐resolution mass spectrometry
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140.
Fast atom bombardment mass spectrometry (FAB-MS) and high resolution (400 Mz) proton nuclear magnetic resonance (NMR spectroscopy) on the competitive angiotensin II antagonist, |Sar1, Tyr(Me)4 (ANGII (Sarmesin) and its he-ptapeptide homolog, [Tyr(Me)3 |ANGIII, yield spectra which provide confirmation of structure and molecular weight. The characteristics of the spectra are discussed and compared with the spectra of natural ANG II, ANG III and |Sar1|ANG II. The NMR data are suggestive of interactions in angiotensin between: 1) the phenolic hydroxyl group and the imidazole ring, and 2) the N-terminal amino group and the Tyrring. These interactions may be important for the formation of the proposed charge transfer system in angiotensin II involving the phenoxyl and α-carboxylate groups. 相似文献