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排序方式: 共有441条查询结果,搜索用时 31 毫秒
31.
Montserrat Cortina‐Puig Anastasia C. H. Scangas Zachary S. Marchese Silvana Andreescu Jean‐Louis Marty Carole Calas‐Blanchard 《Electroanalysis》2010,22(20):2429-2433
This paper describes the development of a xanthine oxidase/poly‐m‐phenylenediamine (XOD‐PPD)‐modified electrode. The biosensor was constructed by encapsulating XOD in a sol‐gel matrix deposited onto a platinum based screen‐printed electrode functionalized with a permselective PPD membrane. The hydrogen peroxide generated as a final product of the enzymatic reaction between the hypoxanthine and the XOD or by the spontaneous dismutation of superoxide radicals was selectively monitored at +700 mV. The use of a highly selective PPD layer blocked the nonspecific oxidation of other oxidizable molecules. Finally the biosensor was applied to the determination of the antioxidant capacity of acetylsalicylic acid. 相似文献
32.
Enikö Kádár David M. Lowe Montserrat Solé Andrew S. Fisher Awadhesh N. Jha James W. Readman Thomas H. Hutchinson 《Analytical and bioanalytical chemistry》2010,396(2):657-666
Nano-Fe particle uptake was experimentally examined in vitro using excised gills and blood cells of the edible blue mussel
Mytilus sp. Whole gills were exposed to both Fe2O3 nanoparticles and a solution of the hydrated FeCl3 salt, for up to 12 h, and blood cells for 30 min. Equimolar Fe+3 in the nano- and the soluble form was estimated under the assumption of dense spherical particles accommodating the same
number of Fe+3 as in the dissolved salt solution, namely: 1,000 μg L−1 Fe2O3 equivalent to 100 μg L−1 FeCl3·6H2O. Putative toxic impact of nano-Fe in gill epithelia and blood cells was assessed by an array of techniques including light-
and electron microscopy, biomarkers for oxidative stress (lipid peroxidation levels), neurotoxic effects (acetylcholinesterase
activity) and cytotoxicity (neutral red retention). Total and filtered fractions (20 and 200 nm, respectively) of Fe were
analysed by ICP-OES. Our results provide evidence for the following: (1) much of both the soluble (95%) and the nano-Fe (90%)
were removed from the water column within 12 h; (2) dissolved- and nano-Fe seemed to follow different routes of uptake within
the gill epithelium; (3) both nano-Fe and soluble FeCl3 caused similar impairment of lysosomal stability in circulating blood cells; (4) lipid peroxidation in gills exposed to the
two distinct forms of Fe was increased, while acetylcholinesterase activity was unaffected. In these short-term in vitro studies,
there appears to be little difference in toxic response between exposure to the Fe salt and the nano-Fe indicating that, in
this case, the nanoparticles do not invoke special properties affecting biological function in gills. However, with the use
of nano-Fe as a food additive, clearly longer-term in vivo studies are warranted. 相似文献
33.
Montserrat Solé Jennifer P. Shaw Patricia E. Frickers James W. Readman Thomas H. Hutchinson 《Analytical and bioanalytical chemistry》2010,396(2):649-656
Environmental risk assessments of human pharmaceuticals and other ‘emerging contaminants’ should integrate both population-relevant
endpoints and biomarkers of potential modes of action in a range of species. Adult Mytilus galloprovincialis were exposed to the beta-adrenergic receptor blocker propranolol or to the anti-inflammatory drug acetaminophen (paracetamol),
both commonly used therapeutic drugs present in aquatic ecosystems. Mussels were exposed under semi-static conditions for
10 days to either acetaminophen (CAS number 103-90-2; mean measured concentrations 23 and 403 μg/L) or propranolol hydrochloride
(CAS number 318-98-9; mean measured propranolol concentrations 11 and 147 μg/L) at 15 ± 1 °C sea water. Feeding rate was assessed
as an indicator of general toxicity. For propranolol, the 10-day no-observed effect concentration (feeding rateNOEC) and lowest observed effect concentration (feeding rateLOEC) were 11 and 147 μg/L, respectively. For acetaminophen, feeding rate was increased at both 23 and 403 μg/L, suggesting
a 10-day feeding rateNOEC of 403 μg/L. Primarily, phase I carboxylesterase (CbE), phase II glutathione S-transferase (GST) and the anti-oxidant catalase activities were evaluated in digestive gland. Gill GST and acetylcholinesterase
(AChE) activities were also measured. Lipid peroxidation (LPO) levels were measured in both tissues to assess oxidative stress.
Some enzymatic activities in liver were also reduced after propranolol exposure whilst acetaminophen enhanced them (CbE p < 0.05). Acetaminophen exposure significantly increased hepatic LPO levels and inhibited AChE activity in gill (10-day NOEC
and LOEC of 23 and 403 μg/L, respectively), whereas propranolol (11 μg/L) enhanced gill GST. 相似文献
34.
35.
Javier Mazuela Alexander Paptchikhine Oscar Pàmies Pher G. Andersson Montserrat Diéguez 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(15):4567-4576
A library of readily available phosphite–oxazole/thiazole ligands ( L1 a – g – L7 a – g ) was applied in the Ir‐catalyzed asymmetric hydrogenation of several largely unfunctionalized E‐ and Z‐trisubstituted and 1,1‐disubstituted terminal alkenes. The ability of the catalysts to transfer chiral information to the product could be tuned by choosing suitable ligand components (bridge length, the substituents in the heterocyclic ring and the alkyl backbone chain, the configuration of the ligand backbone, and the substituents/configurations in the biaryl phosphite moiety), so that enantioselectivities could be maximized for each substrate as required. Enantioselectivities were therefore excellent (enantiomeric excess (ee) values up to >99 %) for a wide range of E‐ and Z‐trisubstituted and 1,1‐disubstituted terminal alkenes. The biaryl phosphite moiety was a very advantageous ligand component in terms of substrate versatility. 相似文献
36.
Anna Fàbregas-Fernández Encarna García-Montoya Pilar Pérez-Lozano Josep M. Suñé-Negre Josep Ramon Ticó Montserrat Miñarro 《Accreditation and quality assurance》2010,15(5):297-304
There is currently no universal or standardized quality system for the recognition of excellence of a research center. Knowledge
and competence may not be enough in the current rapidly changing world in which high productivity and continuous improvement
are essential. The purpose of this study was to assess the impacts of implementing the ISO9001:2000:2000 standard in an academic
research center dedicated to R+D+I (research, development and innovation) in the pharmaceutical industry. The article describes
the stages we followed to implement the ISO9001:2000 system, which was achieved by integrating it into the previous regulatory
system of GMP (Good Manufacturing Practices). As a result of implementing ISO9001:2000, the center has seen distinct improvements,
such as fewer errors in project documentation, improved assessment of customer satisfaction, and the effective implementation
of periodic plans, e.g., in calibration, preventive maintenance, and investments. Overall, ISO9001:2000 implementation has
been beneficial for the organization and could be applied to other research centers. 相似文献
37.
Expertons and uncertain aggregation operators are tools for dealing with imprecise information that can be assessed with interval numbers. This paper introduces the uncertain generalized probabilistic weighted averaging (UGPWA) operator. It is an aggregation operator that unifies the probability and the weighted average in the same formulation considering the degree of importance that each concept has in the aggregation. Moreover, it is able to assess uncertain environments that cannot be assessed with exact numbers but it is possible to use interval numbers. Thus, we can analyze imprecise information considering the minimum and the maximum result that may occur. Further extensions to this approach are presented including the quasi-arithmetic uncertain probabilistic weighted averaging operator and the uncertain generalized probabilistic weighted moving average. We analyze the applicability of this new approach in a group decision making problem by using the theory of expertons in strategic management. 相似文献
38.
Antonia Camacho Montserrat Montaña Isabel Vallés Ricard Devesa Raquel Céspedes-Sánchez Isabel Serrano 《Journal of Radioanalytical and Nuclear Chemistry》2013,295(1):297-306
22 sludge samples were analyzed from three municipal wastewater treatment plants to assess both the occurrence and the temporal behavior of radioactivity during 8 sampling campaigns carried out over the period 2007–2009. As regards natural gamma emitters radionuclides from the natural 238U series (such as 234Th, 214Pb, 214Bi, 210Pb) and the 232Th series (such as 228Ac, 212Pb, 212Bi and 208Tl) and other natural gamma emitters such as 7Be, 210Pbu or 40K were measured. In the case of man-made radionuclides small amounts of 137Cs were found, while significant amounts of 131I were detected in some samples. Correlations were found between radionuclides with the same origin. No seasonal variation for the 238U and 232Th series was found in the studied period but 7Be and 210Pbu showed seasonal variation that was explained by the monthly rainfall. The internal and external hazard indices were calculated and the results indicate that the radiological characteristics of the sludge do not present a significant radiological risk and make them suitable for future applications. 相似文献
39.
Javier Mazuela Oscar Pàmies Montserrat Diéguez Laetitia Palais Stephane Rosset Alexandre Alexakis 《Tetrahedron: Asymmetry》2010,21(17):2153-2157
A biaryl-based monophosphoroamidite L1–L4a–f and aminophosphine L5–L7a–f ligand library was screened in the Rh-catalyzed asymmetric hydroformylation of several vinylarenes and heterocyclic olefins. Our results indicate that the selectivity is strongly dependent on the ligand parameters and on the substrate type. Enantioselectivities (up to 46%) were moderate in the hydroformylation of several vinylarenes S1–S5 and promising (up to 58%) for the more challenging heterocyclic olefins S6–S9. 相似文献
40.
Montserrat Guillen Faustino Prieto José María Sarabia 《Insurance: Mathematics and Economics》2011,49(3):454-461
This paper focuses on modelling the severity distribution. We directly model the small, moderate and large losses with the Pareto Positive Stable (PPS) distribution and thus it is not necessary to fix a threshold for the tail behaviour. Estimation with the method of moments is straightforward. Properties, graphical tests and expressions for value-at risk and tail value-at-risk are presented. Furthermore, we show that the PPS distribution can be used to construct a statistical test for the Pareto distribution and to determine the threshold for the Pareto shape if required. An application to loss data is presented. We conclude that the PPS distribution can perform better than commonly used distributions when modelling a single loss distribution for moderate and large losses. This approach avoids the pitfalls of cut-off selection and it is very simple to implement for quantitative risk analysis. 相似文献