PHOTOSENSITIZING PROPERTIES OF BACTERIOCHLOROPHYLLIN a and BACTERIOCHLORIN a, TWO DERIVATIVES OF BACTERIOCHLOROPHYLL a

Abstract The photosensitizing properties of two water soluble derivatives of bacteriochlorophyll a , bacteriochlorophyllin a and bacteriochlorin a (lacking the central Mg-ion) were investigated and compared to those of hematoporphyrin derivatives. At physiological pH the oxygen consumption rate of histidine, tryptophan, dithiothreitol and guanosine upon illumination was 3 to 4 times higher when bacteriochlorin a was used as photosensitizer than when hematoporphyrin derivatives were used. Especially bacteriochlorin a proved to be an effective sensitizer for the killing of L929 cells. Because bacteriochlorin a has an absorption maximum at 765 nm in phosphate buffered saline (allowing a light penetration in tissue about ten times larger than at 630 nm) and a high molar absorption coefficient (32 000 M cm⁻¹) it has promising possibilities for the application in photodynamic therapy.     

Neue Cyclosporine aus Tolypocladium inflatum. Die Cyclosporine K–Z

Novel Cyclosporins from Tolypocladium inflatum. The Cyclosporins K–Z The fungus T. inflatum produces a plethora of oligopeptides, the cyclosporins, which exhibit remarkable biological activities. Cyclosporin A, the main metabolite, represents a potent immunosuppressant which opened new ways in the immunotherapy of bone marrow and organ transplantations. In addition to the already described cyclosporins A–I, we report now the isolation of the cyclosporins K–Z. The structural assignments of these novel congeners are based on chemical degradation, correlation reactions, mass spectra, and extensive analysis of ¹H- and ¹³C-NMR spectra. All cyclosporins are cyclic undecapeptides differing from each other by minor variations in the amino-acid sequence. Comparison of the immunosuppressive and antifungal effects furnished new information concerning structure-activity relationships.     

Crystal and molecular structures ofp-(1,1,3,3-tetramethylbutyl)calix[5]arene and its 1 : 1 complex with toluene

A cyclic pentamer was obtained fromp-(1,1,3,3-tetramethylbutyl) phenol. It crystallizes from a mixture of acetone and toluene at room temperature giving a 1 : 1 complex with toluene (compound A), whereas at 50°C the empty form (compound B) is obtained. Crystals of A are orthorhombic, space groupPna2₁,a = 20.083(2),b = 12.936(6),c = 28,423(1) Å,Z = 4, finalR value = 0.067. The empty form, B, is monoclinicP2₁/c,a = 18.695(2),b = 11.673(5),c = 35.100(4) Å, = 114.33(1),Z = 4, finalR value = 0.135. The macrocycle is in the cone conformation for both compounds; the toluene molecule lies in the cone as often found for calix[4]arenes.     

Mechanism of Formation of Peroxocarbonates RhOOC(O)O(Cl)(P)(3) and Their Reactivity as Oxygen Transfer Agents Mimicking Monooxygenases. The First Evidence of CO(2) Insertion into the O-O Bond of Rh(eta(2)-O(2)) Complexes

Extended labeling experiments have shown that formation of rhodium peroxocarbonate from CO(2) and [RhCl(eta(2)-O(2))(P)(3)] (P is PEt(2)Ph or PEtPh(2)) proceeds through O-O bond cleavage and CO(2) insertion. O-transfer to ancillary phosphine ligand to give R(3)P=O selectively (>85%) involves the Rh-linked O atom of the peroxo group of RhCl(CO(4))(P)(3).     

Di‐ and tri‐organotin derivatives of 3S,4S‐3‐[(R)‐1‐(tert‐butyl‐dimethylsilyloxy)ethyl]‐4‐[(R)‐1‐carboxyethyl]‐2‐azetidinone: synthesis,characterization and in vitro antitumour activity

Di‐n‐butyl‐, triphenyl and tri‐n‐butyltin derivatives of 3 S, 4 S ‐3‐[( R )‐1‐(tert‐butyldimethyl‐­<?tw=103.5%>silyloxy)ethyl‐4‐[( R )‐1‐carboxyethyl]‐2‐azetidi<?tw>‐­none were synthesized and characterized. Their antitumour activity was screened against seven tumoural cell lines of human origin. Copyright © 1999 John Wiley & Sons, Ltd.     

Regioselectivite de la reaction des dialkyl cuprates de magnesium sur des aldehydes α,β-ethyleniques

Various magnesium organocuprates give conjugative addition products with α,β-ethylenic aldehydes, and even with acrolein. The enolates may be trapped with bromine or trimethylsilyl chloride.     

Families of curves with ordinary singular points on regular surfaces

Sunto Fissata una superficie algebrica liscia X sopra un campo algebricamente chiuso e di caratteristica 0, e una curva ridotta C su X, si introduce, per ogni -upla di numeri naturali m₁,..., m, uno schema W=W(C, m₁,..., m), parametrizzante le curve del sistema lineare ¦C¦ con punti multipli ordinari di molteplicità almeno m₁,..., m. Si studia W in relazione con la configurazione delie singolarità e delle componenti irriducibili di C. Si prova in particolare un teorema di «virtuale connessione», che permette di stabilire l'esistenza di curve irriducibili in alcuni di tali schemi W.

---

---

Membro del G.N.S.A.G.A. del C.N.R.     

The cut cone III: On the role of triangle facets

The cut polytopeP _n is the convex hull of the incidence vectors of the cuts (i.e. complete bipartite subgraphs) of the complete graph onn nodes. A well known class of facets ofP _n arises from the triangle inequalities:x _ij +x _ik +x _jk ≤ 2 andx _ij -x _ik -x _jk ≤ 0 for 1 ≤i,j, k ≤n. Hence, the metric polytope M_n, defined as the solution set of the triangle inequalities, is a relaxation ofP _n . We consider several properties of geometric type for P_n, in particular, concerning its position withinM _n . Strengthening the known fact ([3]) thatP _n has diameter 1, we show that any set ofk cuts,k ≤ log₂ n, satisfying some additional assumption, determines a simplicial face ofM _n and thus, also, ofP _n . In particular, the collection of low dimension faces ofP _n is contained in that ofM _n . Among a large subclass of the facets ofP _n , the triangle facets are the closest ones to the barycentrum of P_n and we conjecture that this result holds in general. The lattice generated by all even cuts (corresponding to bipartitions of the nodes into sets of even cardinality) is characterized and some additional questions on the links between general facets ofP _n and its triangle facets are mentioned.     

Triangulations in CGAL

This paper presents the main algorithmic and design choices that have been made to implement triangulations in the computational geometry algorithms library .