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271.
Cu(I)‐Catalyzed Regioselective and Highly Efficient One‐Pot Synthesis of Novel 1,2,3‐Triazoles Decorated with Pyridine and Heterocyclic Amines
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Khushbu Kushwaha Monika Vashist Mahesh Chand Subhash C. Jain 《Journal of heterocyclic chemistry》2016,53(4):1106-1112
An efficient one‐pot synthesis of 1,2,3‐triazoles via the three‐component coupling reaction between propargyl bromide, secondary amines, and 3‐azidopyridine in the presence of CuI as catalyst has been presented. The reaction is highly regioselective and afforded novel 1,4‐disubstituted‐1,2,3‐triazoles in excellent yields by the [3 + 2] Huisgen cycloaddition reaction. This method avoids isolation and handling of terminal acetylenes. The ease of purification has made this methodology clean and safe for the synthesis of 1,2,3‐triazoles with a broad scope. 相似文献
272.
Therapeutic drug monitoring of cefepime with micellar electrokinetic capillary chromatography: Assay improvement,quality assurance,and impact on patient drug levels
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Regula Theurillat Jeannine Joneli Ursula Wanzenried Jeannette Schiess Monika Hurni Thomas Weber Parham Sendi Wolfgang Thormann 《Journal of separation science》2016,39(13):2626-2632
The improvement and performance of a micellar electrokinetic capillary chromatography assay for cefepime in human serum and plasma with a 50 μm id fused‐silica capillary elongated from 40 to 60 cm is reported. Sample preparation with dodecylsulfate protein precipitation at pH 4.5, the pH 9.1 separation medium, and the applied voltage were as reported previously [16]. The change resulted in a significant lower current, higher resolution, and increased detection time intervals. The performance of the assay with multilevel internal calibration was assessed with calibration and control samples. Quality assurance data of a 2‐year period assessed under the new conditions demonstrated the robustness of the assay. In serum samples of patients who received both cefepime and sulfamethoxazole, cefepime could not be detected due to the inseparability of the two compounds. The presence of an interference can be recognized by an increased peak width (width > 0.2 min), the appearance of a shoulder or an unresolved double peak. The patient data gathered during a 3‐year period reveal that introduction of therapeutic drug monitoring led to a 50% reduction of the median drug level. The data suggest that therapeutic drug monitoring can help to minimize the risk of major adverse reactions and to increase drug safety on an individual basis. 相似文献
273.
274.
Fractions of triterpenoids have been isolated from herb, inflorescences, and rhizomes with roots of Hieracium pilosella by typical extraction with petroleum ether. The fraction from inflorescences was investigated using GC-MS techniques. The occurrence of alpha- and beta-amyrin, taraxerol, taraxasterol, and fern-7en-3beta-ol has been observed. Quantitative analysis was also performed and taraxasterol is distinctly predominant in this triterpenoid fraction. Thin-layer chromatography on silica gel was performed on all the investigated fractions and additionally revealed the occurrence of lupeol and psi-taraxasterol in vestigial quantities. All of the triterpenoid components are reported for the first time in the investigated plant. 相似文献
275.
Dominska M Mazur M Greenough KP Koan MM Krysiński PG Blanchard GJ 《Bioelectrochemistry (Amsterdam, Netherlands)》2007,70(2):421-434
We have investigated the local organization intrinsic to a variety of interfacial structures, by both electrochemical and spectroscopic means. Our focus has been on the design and construction of biomimetic interfaces, where a lipid bilayer or a hybrid bilayer membrane can be bound to an interface. The goal of this work is ultimately to create an interface on a transducer surface that can support an enzyme in its active form. To this point, we have examined the extent of organization that is achievable in monolayers that will be used to bind bilayer structures to a transducer surface. Our electrochemical data point to the important role of the substrate surface in determining adlayer organization. We have also investigated the fluidity and structural heterogeneity of lipid bilayers using time-resolved and steady state fluorescence spectroscopy. Our data point to the highly interactive nature of lipid bilayer constituents, where perturbations introduced to one region have significant consequences on other regions of the bilayer. Such information is directly relevant to the existence and properties of lipid raft structures in both model and biological bilayers. 相似文献
276.
277.
Majerowicz M Waring AJ Wen S Bringezu F 《The journal of physical chemistry. B》2007,111(14):3813-3821
This paper reports the first study on the interaction of the antimicrobial peptide dicynthaurin with 1,2-dipalmitoyl-glycerophosphatidyl-glycerol investigated in monolayers at the air-liquid interface. The influence of the peptide on the two-dimensional phase behavior of the negatively charged lipid was elucidated by means of pressure-area isotherm measurements, fluorescence microscopy, and grazing incidence X-ray diffraction measurements. The pure peptide forms a stable monolayer at the air-liquid interface up to 30 mN/m as shown for both the monomeric and the dimeric cynthaurins. The peptide lipid interaction was monitored in isotherm measurements showing a strong adsorption of the peptide and stabilization at the interface promoted by the lipid monolayer. The X-ray diffraction measurements in agreement with fluorescence microscopy studies showed that the peptide destabilizes the condensed chain lattice, leading to a complete fluidization of the condensed lipid phase on physiological buffer. The adsorption of the peptide to the negatively charged lipid monolayer and the fluidization of the condensed chain lattice suggest a direct link to the peptides' ability to expand the bacterial membrane that would be relevant for the in vivo mode of action. 相似文献
278.
We have demonstrated that small organic molecules 1 and 2 catalyzed the direct aldol reaction of both acyclic and cyclic ketones with different aldehydes in an excess of water/brine. Excellent enantioselectivities up to >99% and diastereoselectivities up to 99% with very good yields were obtained by using much lower catalyst loadings (0.5 mol %). 相似文献
279.
Sulekh?ChandraEmail author Archana?Gautam Monika?Tyagi 《Transition Metal Chemistry》2007,32(8):1079-1084
Cobalt(II), nickel(II) and copper(II) complexes are synthesized with 1,3,7,9-tetraaza- 4,6,10,12-tetraphenyl-2,8-dithiacyclododecane,
a tetradentate ligand (L) and characterized by elemental analysis, molar conductance measurements, magnetic susceptibitity
measurements, mass, i.r., electronic and e.p.r. spectral studies. All the complexes are non-electrolytes so they may be formulated
as [M(L)X2] [where, M = Co(II), Ni(II) and Cu(II) and X = Cl− and NO
3
−
]. All the complexes are of high spin type. On the basis of i.r., electronic and e.p.r. spectral studies an octahedral geometry
has been assigned for Co(II) and Ni(II) complexes and tetragonal geometry for Cu(II) complexes. The antimicrobial activities
of the ligand and its complexes, as growth inhibiting agents, have been screened in vitro against two different species of bacteria and plant pathogenic fungi. 相似文献
280.