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51.
Milasi Monica Scopelliti Domenico 《Journal of Optimization Theory and Applications》2021,190(3):879-893
Journal of Optimization Theory and Applications - We introduce a variational approach to study a maximization problem of preferences that cannot be represented by a utility function. In such... 相似文献
52.
Caroline Mesmann Monica Sigovan Lise-Prune Berner Adva Abergel François Tronc Y. Berthezène P. Douek Loic Boussel 《Magnetic resonance imaging》2014
Purpose
To compare diffusion weighted imaging with background suppression (DWIBS) sequence with classic spectral diffusion sequence (DWI) with and without respiratory gating in mediastinal lymph node analysis at 3 T.Materials and methods
26 patients scheduled for mediastinoscopic lymph node analysis, prospectively undergone a thoracic 3 T MRI with DWIBS (FatSat = STIR; TR/TE = 6674.1/44.7 ms; IR = 260 ms) and DWI sequences (FatSat = SPIR; TR/TE = 1291/59.6 ms) (b = 0-400-800 s/mm2) with and without (free breathing) respiratory gating.Images at b = 800 were analyzed by two radiologists. They performed qualitative analysis of fat-sat homogeneity and motion artifacts, rated from 0 to 4, and quantitative evaluation by studying signal to background (STB) of lymph nodes.Results
Quality of fat suppression was significantly higher for DWIBS than for DWI both for free-breathing (score 3.48 ± 0.65 vs. 1.76 ± 0.96, p < 0.0001) and respiratory-gated scans (3.17 ± 0.77 vs. 1.72 ± 0.73, p = 0.0001). Similarly, artifacts were reduced with DWIBS (3.16 ± 0.47 vs. 1.76 ± 0.59, p < 0.0001; 3.0 ± 0.73 vs. 2.04 ± 0.53, p = 0.0001). Quantitative analysis showed higher STB with DWIBS (3.26 ± 1.83 vs. 0.98 ± 0.44, p < 0.0001; 3.56 ±, 2.09 vs. 0.92 ± 0.59, p < 0.0001). Gating did not improve image quality and STB on DWIBS (p > 0.05).Conclusion
In thoracic MRI, ungated DWIBS sequence improves fat-sat homogeneity, reduces motion artifacts and increases STB of lymph nodes. Respiratory gating does not improve DWIBS image quality. 相似文献53.
54.
Zirconium-doped hematite particles of the type xZrO2-(1−x)α-Fe2O3 (x=0.1, 0.5) were synthesized using mechanochemical activation and characterized by X-ray diffraction (XRD) and Mössbauer spectroscopy. For x=0.1 all zirconia was dissolved in the hematite lattice after 12 h of ball milling and a particle size of 9 nm was obtained. We obtained the recoilless fraction as function of the ball milling time for each value of the molar concentration x. The appearance of nanoparticles in the system was demonstrated based on these plots. We further correlated the structural properties of the zirconium-doped hematite system with the sensing properties of the best candidate in the series. These were measured as function of temperature, gas concentration (carbon monoxide and methane) and variable humidity of air. The material system was found to be sensitive over the entire range of CO concentrations and the linearity of the sensor signal was not affected by the relative humidity of air, qualities which make it the ideal system for gas sensing. 相似文献
55.
Dr. Francesco Della Monica Dr. Veronica Paradiso Prof. Dr. Alfonso Grassi Dr. Stefano Milione Prof. Dr. Luigi Cavallo Prof. Dr. Carmine Capacchione 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(24):5347-5353
A new chromium(III) complex, bearing a bis-thioether-diphenolate [OSSO]-type ligand, was found to be an efficient catalyst in the copolymerization of CO2 and epoxides to achieve poly(propylene carbonate), poly(cyclohexene carbonate), poly(hexene carbonate) and poly(styrene carbonate), as well as poly(propylene carbonate)(cyclohexene carbonate) and poly(propylene carbonate)(hexene carbonate) terpolymers. 相似文献
56.
Monica Chiapetto Lorenzo Malerba Athina Puype Charlotte S. Becquart 《physica status solidi (a)》2016,213(11):2981-2987
57.
Neel Sisodia Monica Miranda Kay L. McGuinness Jay D. Wadhawan Nathan S. Lawrence 《Electroanalysis》2021,33(3):559-562
This work presents the electrochemical response of a 2-(methylthio)phenol glassy carbon based electrode for a promising voltammetric pH sensor in both buffered and low-buffered solutions. Electropolymerization of the redox species was performed with the resulting polymer presenting a Nernstian response in buffered media, with a sensitivity of 51 mV/pH unit. The effectiveness of the sulfhydryl bond to facilitate proton transfer from the bulk solution to the phenol molecules has been confirmed, providing an accurate pH measurement of 8.28 in sea water media, compared to that measured with a calibrated glass pH probe of 8.30. 相似文献
58.
Monica Gallo Domenico Montesano Martina Ciaravolo Fulvio De Paola Giovanni Dal Poggetto Daniele Naviglio 《Macromolecular Symposia》2021,395(1):2000211
The aging process of wine goes beyond conservation and involves the use of wood, which is capable of containing and protecting, and allows a limited passage of oxygen, sufficient to promote slow maturation of the wine, thanks to which it reaches the maximum of its organoleptic qualities. The most used wood is oak and during aging, the wine extracts from the wood of the barrels an abundant quantity of aromatic substances, due to the contact between the wine and the matrix of the wood. Among the newly formed compounds, the flavano‐ellagitannins, namely the acutissimin A and B, are the minor compounds found in wood aged wine. They are formed during the aging process through the condensation of tannins, such as vescalagin, extracted from the wood matrix and flavonoids, such as catechins contained in wine. The aim of the study is to verify the formation of acutissimins after 28 days in model solutions that simulated aged wine in the presence of 1%, 5%, and 10% w/v percentages of wood chips obtained from Quercus alba and with variable concentrations of catechin (100 and 500 mg L−1). The formation of compounds, including acutissimin A and B, and the disappearance of catechin are identified by high‐performance liquid chromatography/electrospray ionization/mass spectrometry. Acutissimins A and B are validated by comparison with the characteristic m/z reported in the literature. Based on the results obtained, the model system prepared with 500 mg L−1 of catechin and 10% w/v oak chips showed the highest content of acutissimin A and B. 相似文献
59.
Salvador Guardiola Monica Varese Xavier Roig Macarena Snchez-Navarro Jesús García Ernest Giralt 《Chemical science》2021,12(14):5164
Peptides are a rapidly growing class of therapeutics with various advantages over traditional small molecules, especially for targeting difficult protein–protein interactions. However, current structure-based methods are largely limited to natural peptides and are not suitable for designing bioactive cyclic topologies that go beyond natural l-amino acids. Here, we report a generalizable framework that exploits the computational power of Rosetta, in terms of large-scale backbone sampling, side-chain composition and energy scoring, to design heterochiral cyclic peptides that bind to a protein surface of interest. To showcase the applicability of our approach, we developed two new inhibitors (PD-i3 and PD-i6) of programmed cell death 1 (PD-1), a key immune checkpoint in oncology. A comprehensive biophysical evaluation was performed to assess their binding to PD-1 as well as their blocking effect on the endogenous PD-1/PD-L1 interaction. Finally, NMR elucidation of their in-solution structures confirmed our de novo design approach. In silico design of heterochiral cyclic peptides that bind to a specific surface patch on the target protein (PD-1, in this case) and disrupt protein–protein interactions. 相似文献
60.
Gabriel Hancu Daniela Lupu Andreea Milan Monica Budu Enik Barabs‐Hajdu 《Biomedical chromatography : BMC》2021,35(1)
Venlafaxine (VFX) is a serotonin and norepinephrine reuptake inhibitor chiral drug used in therapy as an antidepressant in the form of a racemate consisting of R‐ and S‐VFX. The two enantiomers of VFX exhibit different pharmacological activities: R‐VFX inhibits both norepinephrine and serotonin synaptic reuptake, whereas S‐VFX inhibits only the serotonin one. R‐ and S‐VFX are metabolized in the liver to the respective R‐ and S‐O‐desmethylvenlafaxine (ODVFX), R‐ and S‐N‐desmethylvenlafaxine (NDVFX), and R‐ and S‐N,O‐didesmethylvenlafaxine (NODVFX). The pharmacological profile of ODVFX is close to that of VFX, whereas the other two chiral metabolites (NDVFX and NODVFX) have lower affinity for the receptor sites. The pharmacokinetics of the VFX enantiomers appear stereoselective, including the metabolism process. In the past 20 years, several studies describing the enantioselective analysis of R‐ and S‐VFX in pharmaceutical formulations and its chiral metabolites in biological matrices were published. These methods encompass liquid chromatography coupled with UV detection, mass spectrometry, or tandem mass spectrometry, and capillary electrophoresis. This paper reviews the published methods used for the determination of the individual enantiomers of VFX and its chiral metabolites in different matrices. 相似文献