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排序方式: 共有1461条查询结果,搜索用时 15 毫秒
961.
Soumya Menon Santhoshkumar Jayakodi Kanti Kusum Yadav Prathap Somu Mona Isaq Venkat Kumar Shanmugam Amballa Chaitanyakumar Nagaraj Basavegowda 《Molecules (Basel, Switzerland)》2022,27(21)
The potentiality of nanomedicine in the cancer treatment being widely recognized in the recent years. In the present investigation, the synergistic effects of chitosan-modified selenium nanoparticles loaded with paclitaxel (PTX-chit-SeNPs) were studied. These selenium nanoparticles were tested for drug release analysis at a pH of 7.4 and 5.5, and further characterized using FTIR, DLS, zeta potential, and TEM to confirm their morphology, and the encapsulation of the drug was carried out using UPLC analysis. Quantitative evaluation of anti-cancer properties was performed via MTT analysis, apoptosis, gene expression analysis, cell cycle arrest, and over-production of ROS. The unique combination of phytochemicals from the seed extract, chitosan, paclitaxel, and selenium nanoparticles can be effectively utilized to combat cancerous cells. The production of the nanosystem has been demonstrated to be cost-effective and have unique characteristics, and can be utilized for improving future diagnostic approaches. 相似文献
962.
Ali A. Rabaan Abbas Al Mutair Hawra Albayat Jawaher Alotaibi Tarek Sulaiman Mohammed Aljeldah Basim R. Al Shammari Amal H. Alfaraj Mona A. Al Fares Sara Alwarthan Abdulwahab Z. Binjomah Mohammed S. Alzahrani Hatem M. Alhani Mohammed S. Almogbel Abdulmonem A. Abuzaid Ghaya Alqurainees Fatimah Al Ibrahim Ali H. Alhaddad Mubarak Alfaresi Nadira Al-baghli Saad Alhumaid 《Molecules (Basel, Switzerland)》2022,27(20)
Mycobacterium tuberculosis (Mtb), an acid-fast bacillus that causes Tuberculosis (TB), is a pathogen that caused 1.5 million deaths in 2020. As per WHO estimates, another 4.1 million people are suffering from latent TB, either asymptomatic or not diagnosed, and the frequency of drug resistance is increasing due to intrinsically linked factors from both host and bacterium. For instance, poor access to TB diagnosis and reduced treatment in the era of the COVID-19 pandemic has resulted in more TB deaths and an 18% reduction in newly diagnosed cases of TB. Additionally, the detection of Mtb isolates exhibiting resistance to multiple drugs (MDR, XDR, and TDR) has complicated the scenario in the pathogen’s favour. Moreover, the conventional methods to detect drug resistance may miss mutations, making it challenging to decide on the treatment regimen. However, owing to collaborative initiatives, the last two decades have witnessed several advancements in both the detection methods and drug discovery against drug-resistant isolates. The majority of them belong to nucleic acid detection techniques. In this review, we highlight and summarize the molecular mechanism underlying drug resistance in Mtb, the recent advancements in resistance detection methods, and the newer drugs used against drug-resistant TB. 相似文献
963.
Mona Spiegel-Adolf 《Colloid and polymer science》1926,38(2):127-129
Ohne Zusammenfassung
Vorgetragen auf der IV. Hauptversammlung der Kolloidgesellschaft 5.–7. September 1925 in Nürnberg. Das diesem Vortrage zugrunde
liegende Versuchsmaterial wird in der ausführlichen Arbeit (erscheint in der Biochem. Zeitschrift) mitgeteilt werden. 相似文献
964.
Momeni Mohamad Mohsen Akbarnia Mehrdad Atapour Masoud Khalaghi Mona 《Journal of Solid State Electrochemistry》2022,26(1):281-291
Journal of Solid State Electrochemistry - Single and co-doped chromium and sulfur TiO2 nanotubes appropriate for photoelectrochemical water splitting application have been prepared and... 相似文献
965.
Larsen Louder 《Israel Journal of Mathematics》2014,199(2):527-545
There are noninjective maps from surface groups to limit groups that don’t kill any simple closed curves. As a corollary, there are noninjective all-loxodromic representations of surface groups to SL(2, ?) that don’t kill any simple closed curves, answering a question of Minsky. There are also examples, for any k, of noninjective all-loxodromic representations of surface groups killing no curves with self-intersection number at most k. 相似文献
966.
Magar Hend Samy Abbas Mohammed Nooredeen Ali Mounir Ben Ahmed Mona A. 《Journal of Solid State Electrochemistry》2020,24(3):723-737
Journal of Solid State Electrochemistry - Analysis of saliva is a potential diagnostic tool in the management of human diseases. Analysis of saliva in healthy individuals is vital to comparison in... 相似文献
967.
968.
Hemmat M. Abd-Elhady Mona A. Ashor Abdelkader Hazem Fayez M. Saleh Samy Selim Nihal El Nahhas Shams H. Abdel-Hafez Samy Sayed Enas A. Hassan 《Molecules (Basel, Switzerland)》2022,27(1)
The ability of microorganisms to reduce inorganic metals has launched an exciting eco-friendly approach towards developing green nanotechnology. Thus, the synthesis of metal nanoparticles through a biological approach is an important aspect of current nanotechnology. In this study, Streptomyces aizuneusis ATCC 14921 gave the small particle of silver nanoparticles (AgNPs) a size of 38.45 nm, with 1.342 optical density. AgNPs produced by Streptomyces aizuneusis were characterized by means of UV-VIS spectroscopy and transmission electron microscopy (TEM). The UV-Vis spectrum of the aqueous solution containing silver ion showed a peak between 410 to 430. Moreover, the majority of nanoparticles were found to be a spherical shape with variables between 11 to 42 nm, as seen under TEM. The purity of extracted AgNPs was investigated by energy dispersive X-ray analysis (EDXA), and the identification of the possible biomolecules responsible for the reduction of Ag+ ions by the cell filtrate was carried out by Fourier Transform Infrared spectrum (FTIR). High antimicrobial activities were observed by AgNPs at a low concentration of 0.01 ppm, however, no deleterious effect of AgNPs was observed on the development and occurrence of Drosophila melanogaster phenotype. The highest reduction in the viability of the human lung carcinoma and normal cells was attained at 0.2 AgNPs ppm. 相似文献
969.
5‐{[(1E)‐(4‐methoxyphenyl)methylene]amino}‐1,3,4‐thiadiazole‐2‐thiol ( 1a ) reacts with trialkyl phosphites ( 2a–c ) to give the respective dialkyl phosphonate adducts ( 4a–c ). On the other hand, the reactions of trisdialkylaminophosphines ( 3a,b ) with 1a , 5‐{[(1E)‐(4‐phenyl)methylene]amino}‐1,3,4‐thiadiazole‐2‐thiol ( 1b ) yield the corresponding open dipolar structures 6a–c . In the case of the reaction of triethyl phosphite ( 2a ) with 1b , both the dialkyl phosphonate adduct ( 7 ) and the dipolar product ( 8a ) are obtained. Moreover, triisopropyl phosphite ( 2c ) reacts with 1b to give both the S‐alkyl and the N‐alkyl phosphonate adducts ( 9a,b ), respectively. Mechanisms are proposed to explain the formation of the new products, and their structures were confirmed on the basis of elemental analysis and spectral studies. © 2001 John Wiley & Sons, Inc. Heteroatom Chem 12:594–601, 2001 相似文献
970.