Time-indexed formulations for scheduling chains on a single machine: An application to airborne radars

Airborne radars are widely used to perform a large variety of tasks in an aircraft (searching, tracking, identifying targets, etc.) Such tasks play a crucial role for the aircraft and they are repeated in a “more or less” cyclic fashion. This defines a scheduling problem that impacts a lot on the quality of the radar output and on the overall safety of the aircraft.     

Development of New Atom Transfer Radical Polymerization System by Iron (III)‐Metal Salts Without Using any External Initiator and Reducing Agent

Atom transfer radical polymerization (ATRP) catalyzed by high oxidation state metal salts of FeX₃ is developed for the first time in the absence of both external initiator and reducing agent. Methyl methacrylate (MMA) and styrene are polymerized successfully using FeX₃/Phosphorous ligands with well‐controlled molecular weight distributions (=1.5). The molecular weight of the polymers increases with monomer consumption with the progress of time and the polymerization behaviors show a decent ATRP trend. Activators and initiators are suggested to generate in situ by the addition reaction of MMA and one equivalent of FeX₃. The PMMA synthesized from without‐initiator system is characterized by ¹H, ¹³C and DEPT (distortionless enhancement by polarization transfer nuclear magnetic resonance) nuclear magnetic resonance spectroscopy. Chain extension and copolymerization experiments prove the livingness of the obtained polymer.

     

Deciphering key proteins of oil palm (Elaeis guineensis Jacq.) fruit mesocarp development by proteomics and chemometrics

Palm oil is an edible vegetable oil derived from lipid‐rich fleshy mesocarp tissue of oil palm (Elaeis guineensis Jacq.) fruit and is of global economic and nutritional relevance. While the understanding of oil biosynthesis in plants is improving, the fundamentals of oil biosynthesis in oil palm still require further investigations. To gain insight into the systemic mechanisms that govern oil synthesis during oil palm fruit ripening, the proteomics approach combining gel‐based electrophoresis and mass spectrometry was used to profile protein changes and classify the patterns of protein accumulation during these complex physiological processes. Protein profiles from different stages of fruit ripening at 10, 12, 14, 15, 16, 18 and 20 weeks after anthesis (WAA) were analysed by two‐dimensional gel electrophoresis (2DE). The proteome data were then visualised using a multivariate statistical analysis of principal component analysis (PCA) to get an overview of the proteome changes during the development of oil palm mesocarp. A total of 68 differentially expressed protein spots were successfully identified by matrix‐assisted laser desorption/ionisation‐time of flight (MALDI‐TOF/TOF) and functionally classified using ontology analysis. Proteins related to lipid production, energy, secondary metabolites and amino acid metabolism are the most significantly changed proteins during fruit development representing potential candidates for oil yield improvement endeavors. Data are available via ProteomeXchange with identifier PXD009579. This study provides important proteome information for protein regulation during oil palm fruit ripening and oil synthesis.     

In reply to “A query on the Mg2p of MgO”

Research on Chemical Intermediates -     

Determining the feasibility of H2O2 production at a graphite cathode using bond dissociation energy: comparing simple and nitrogen doped cathodes

Research on Chemical Intermediates - Hydrogen peroxide (H2O2) is commercially produced by catalytic oxidation of anthrahydroquinone, which is energy-intensive. Electrochemical production of...     

Sulfanyl chloride induced heterocyclization of N-(pyrazolyl)styrylacetamides

Heterocyclization of N-(pyrazol-3-yl)styrylacetamides with arenesulfenyl chlorides yields the corresponding tetrahydrofuran-2-iminium perchlorates isolable after chromatography as trans-5-aryl-4-(arylthio)tetrahydrofuran-2-ones and 5-aryl-4-(arylthio)-1-(pyrazol-3-yl)pyrrolidin-2-ones, with the latter predominating. N-(Pyrazol-4-yl)styrylacetamides react under analogous conditions to give 5-aryl-4-(arylthio)-1-(pyrazol-4-yl)pyrrolidin-2-ones, 4-aryl-3-(arylthio)-4-chloro-N-(1-methylpyrazol-4-yl)butanamides, and tetrahydrofuran-2-iminium perchlorates which, when chromatographed, produce 5-aryl-4-(arylthio)dihydrofuran-2(3H)-ones and 4-aryl-3-(arylthio)-4-methoxy-N-(1-methyl-1H-pyrazol-4-yl)butanamides.     

CuSO4/sodium ascorbate catalysed synthesis of benzosuberone and 1,2,3-triazole conjugates: Design,synthesis and in vitro anti-proliferative activity

A novel series of conjugates of benzosuberone and 1,2,3-triazole i.e. 3-(4-phenyl-1H-1,2,3-triazol-1-yl)propyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzo[7]annulene-8-carboxylic acids (8a-j) were synthesized in good to excellent yields catalysed by CuSO₄ under milder reaction conditions and evaluated for their anti-proliferative activity. The structural elucidation of the prepared compounds was carried out using IR, ¹H NMR, ¹³C NMR and Mass spectral analysis. The newly synthesized derivatives (8a-j) were evaluated for their anti-proliferative activity against four human cell lines and the novel derivatives showed moderate to excellent activity. The obtained results suggest that these compounds can be considered as new hits for anti-proliferative drug development programme and further SAR studies can help obtain better anticancer agents.     

A simple method for extracting both active oily and water soluble extract (WSE) from Nigella sativa (L.) seeds using a single solvent system

The current study provides a way of extraction for both active NSO and WSE from Nigella sativa seeds using 98% methanol. About 1?kg of ground seeds was macerated by 1:2.5 w/v (g/mL) for 72?hours. After rotary evaporation and 7 days of continuous drying and chilling at 50 and 4?°C, NSO and WSE were obtained at the same instant. Solubility tests of 24 solvents and 11 thin layer chromatographic analyses while 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging assay of NSO (73.66) , WSE (33.32) and NSO?+?WSE (78.22) against ascorbic acid (IC50?=?4.28?mg/mL) was performed. WSE was found to be highly soluble in water and 5% NaOH exhibiting the same Rf value of 0.95 for EtOH:DMSO (9:1) against the honey. WSE has revealed more than twofold higher anti-oxidant activity than others. Formulation of WSE with Tualang honey may provide better targeted hydrophilic drug delivery systems.     

Nanofluids thermal performance in the horizontal annular passages: a recent comprehensive review

Journal of Thermal Analysis and Calorimetry - Nanofluids are prepared to enrich thermo-physical and convective heat transfer properties by suspending nanometer particles in a base fluid. For...     

Validated LC–MS/MS method for quantitation of a selective JAK1 inhibitor,filgotinib in rat plasma,and its application to a pharmacokinetic study in rats

Filgotinib is a selective JAK1 (Janus kinase) inhibitor, filed in Japan for the treatment of rheumatoid arthritis. In this paper, we report a validated liquid chromatography coupled with tandem mass spectrometry for the quantification of filgotinib in rat plasma using tofacitinib as an internal standard (IS) as per the Food and Drug Administration regulatory guidelines. Filgotinib and the IS were extracted from rat plasma using ethyl acetate as an extraction solvent and chromatographed using an isocratic mobile phase (0.2% formic acid:acetonitrile; 20:80, v/v) at a flow rate of 0.9 mL/min on a Gemini C₁₈ column. Filgotinib and the IS were eluted at ~1.31 and 0.89 min, respectively. The MS/MS ion transitions monitored were m/z 426.3 → 291.3 and m/z 313.2 → 149.2 for filgotinib and the IS, respectively. The calibration range was 0.78–1924 ng/mL. No matrix effect and carryover were observed. Intra- and inter-day accuracies and precisions were within the acceptance range. Filgotinib was stable for three freeze–thaw cycles: on bench-top up to 6 h, in an autosampler up to 21 h, and at −80 ° C for 1 month. This novel method has been applied to a pharmacokinetic study in rats.