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931.
AbdElAziz A. Nayl Hamada Mohamed Ibrahim Kamal M. Dawood Wael A. A. Arafa Ahmed I. Abd-Elhamid Ismail M. Ahmed Mohamed A. Abdelgawad Hazim M. Ali Ibrahim Hotan Alsohaimi Ashraf A. Aly Stefan Brse Asmaa Kamal Mourad 《Molecules (Basel, Switzerland)》2022,27(19)
An appropriate and efficient Q-tube-assisted ammonium acetate-mediated protocol for the assembly of the hitherto unreported 5-arylazopyrazolo[3,4-b]pyridines was demonstrated. This methodology comprises the cyclocondensation reaction of 5-amino-2-phenyl-4H-pyrazol-3-one with an assortment of arylhydrazonals in an NH4OAc/AcOH buffer solution operating a Q-tube reactor. This versatile protocol exhibited several outstanding merits: easy work-up, mild conditions, scalability, broad substrate scope, safety (the Q-tube kit is simply for pressing and sealing), and a high atom economy. Consequently, performing such reactions under elevated pressures and utilizing the Q-tube reactor seemed preferable for achieving the required products in comparison to the conventional conditions. Diverse spectroscopic methods and X-ray single-crystal techniques were applied to confirm the proposed structure of the targeted compounds. 相似文献
932.
Kamal Y. Thajudeen Yahya I. Asiri Shahana Salam Shabeer Ali Thorakkattil Mohamed Rahamathulla Ilyas Uoorakkottil 《Molecules (Basel, Switzerland)》2022,27(19)
The objectives of this study were to optimize and quantify the maximum percentage yield of eupalitin-3-O-β-D-galactopyranosidefrom Boerhavia diffusa leaves using response surface methodology (RSM), as well as to demonstrate the hepatoprotective benefits of the bioactive compound. The Box–Behnken experimental design was utilized to optimize the eupalitin-3-O-β-D-galactopyranoside extraction procedure, which also looked at the extraction duration, temperature, and solvent concentration as independent variables. Boerhaviadiffusa leaves were extracted, and n-hexane, chloroform, ethyl acetate, and water were used to fractionate the dried extracts. The dried ethyl acetate fraction was thoroughly mixed in hot methanol and stored overnight in the refrigerator. The cold methanol was filtered, the solid was separated, and hot methanol was used many times to re-crystallize the solid to obtain pure eupalitin-3-O-β-D-galactopyranoside (0.1578% w/w). The proposed HPTLC method for the validation and quantification of eupalitin-3-O-β-D-galactopyranosidewassuccessfully validated and developed. The linearity (R2 = 0.994), detection limit (30 ng), and quantification limit (100 ng) of the method, as well as its range (100–5000 ng), inter and intraday precision (0.67% and 0.991% RSD), specificity, and accuracy (99.78% RSD), were all validated as satisfactory. The separation of the eupalitin-3-O-β-D-galactopyranoside band was achieved on an HPTLC plate using toluene:acetone:water (5:15:1 v/v) as a developing system. The Box–Behnken statistical design was used to determine the best optimization method, which was found to be extraction time (90 min), temperature (45 °C), and solvent ratio (80% methanol in water v/v) for eupalitin-3-O-β-D-galactopyranoside. Standard silymarin ranged from 80.2% at 100 µg/mL to 86.94% at 500 µg/mL in terms of significant high hepatoprotection (cell induced with carbon tetrachloride 0.1%), whereas isolated eupalitin-3-O-β-D-galactopyranoside ranged from 62.62% at 500 µg/mL to 70.23% at 1000 µg/mL. More recently, it is a source of structurally unique flavonoid compounds that may offer opportunities for developing novel semi-synthetic molecules. 相似文献
933.
Rudolf GrÜner Zdenka Beneš Ernst Schubert Mohamed Arman 《Monatshefte für Chemie / Chemical Monthly》1927,48(1-2):37-46
Ohne Zusammenfassung 相似文献
934.
Four analogues of ochratoxin A (OTA) differing for the aminoacidic moiety were synthesised using ochratoxin α (OTα) as the starting material. The condensation reaction between protected amino acids and OTα, carried out in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC???HCl) and N-hydroxybenzotriazole (HOBt) as coupling agents, followed by deprotection and PTLC purification afforded OTA alanine, leucine, serine and tryptophane analogues in satisfactory yields (33-47%, based on OTα). 相似文献
935.
936.
Synergistic Effect of Bioactive Monoterpenes against the Mosquito,Culex pipiens (Diptera: Culicidae)
Amal Ramzi Abdelhakim El Ouali Lalami Saoussan Annemer Yassine Ez zoubi Amine Assouguem Mikhlid H. Almutairi Mohamed Kamel Ilaria Peluso Sezai Ercisli Abdellah Farah 《Molecules (Basel, Switzerland)》2022,27(13)
Mosquitoes represent one of the most important vectors and are responsible for the transmission of many arboviruses that affect human and animal health. The chemical method using synthetic insecticides disturbs the environmental system and promotes the appearance of resistant insect species. Therefore, this study investigated the insecticidal effect of some binary monoterpene combinations (1,8 cineole + α-pinene and carvone + R (+)-pulegone) using a mixture design approach. The fumigant toxicity was evaluated against Culex pipiens female adults using glass jars. The results show that the toxicity varies according to the proportions of each compound. Indeed, Mixture 1 (1,8-cineole + α-pinene) displayed a strong toxic effect (51.00 ± 0.86% after 24 h and 100.00 ± 0.70% after 48 h) when the pure compounds were tested at 0.25/0.75 proportions of 1,8-cineole and α-pinene, respectively. Nevertheless, the equal proportion (0.5/0.5) of carvone and R (+)-pulegone in Mixture 2 exhibited a toxic effect of 54.35 ± 0.75% after 24 h and 89.96 ± 0.14% after 48 h, respectively. For Mixture 1, the maximum area of mortality that the proposed model indicated was obtained between 0/1 and 0.25/0.75, while the maximum area of mortality in the case of Mixture 2 was obtained between 0.25/0.75 and 0.75/0.25. Moreover, the maximum possible values of mortality that could be achieved by the validated model were found to be 51.44% (after 24 h) and 100.24% (after 48 h) for Mixture 1 and 54.67% (after 24 h) and 89.99% (after 48 h) for Mixture 2. It can be said that all purev molecules tested through the binary mixtures acted together, which enhanced the insecticide’s effectiveness. These findings are very promising, as the chemical insecticide (deltamethrin) killed only 19.29 ± 0.01% and 34.05 ± 1.01% of the female adults after 24 h and 48 h, respectively. Thus, the findings of our research could help with the development of botanical insecticides that might contribute to management programs for controlling vectors of important diseases. 相似文献
937.
How to scale even the simplest of turbulent flows continues to be a cause for considerable controversy. In the present research, a data base compiling results from channel flow direct numerical simulations and turbulent boundary layer experiments is employed to investigate the properties of shear and normal Reynolds stresses very close to the wall. Two types of scaling based on Kolmogorov length and velocity scales are analyzed. It is shown that it is highly likely that large length scales of the order of the channel half-width or the boundary layer thickness play an important role even in the innermost regions of wall-bounded turbulent flows, which hints at the persistence of Reynolds number effects in even high Reynolds number flows. 相似文献
938.
New guest dye cations within the channel cavities of supramolecular hosts are studied. The guest organic dyes are intercalated in the supramolecular hosts by a coprecipitation reaction to give new dye‐sensitizer coordination polymers. The absorption spectra for the dye molecules within the supramolecular hosts show intense bands in the region from 500 to 700 nm due to the presence of the dyes within the parallel channels in the monomeric forms. The properties of the resulting colored polymers were investigated by IR, UV–vis, fluorescence spectra and X‐ray powder diffraction, indicating the excitation energy transfer from neutral red or pyronine as donors to methylene blue or thionine as acceptors within a supramolecular system filled with a mixture of both dyes. The wide‐ranging tenability of these highly organized materials offers fascinating new possibilities for exploring excitation energy transfer phenomena, and challenges for developing new photonic devices. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
939.
940.
Mohamed Boulanouar 《Comptes Rendus Mathematique》2002,334(10):865-868
In this Note, we complete [1] and we study the Lebowitz–Rubinow's model with the biological law of perfect memory. In this model, each cell is characterized by its cell cycle length l (0?l1<l<l2<∞) and its age a (0<a<l). If l1>0, a complete study of this model can be found in [1]. Here we show that if l1=0 then this model becomes ill-posed. We use the theory of generalized semigroups to remedy to this model. To cite this article: M. Boulanouar, C. R. Acad. Sci. Paris, Ser. I 334 (2002) 865–868. 相似文献