Studies on syntheses and permeabilities of special polymer membranes. 48. Transport of organic ions through crosslinked poly(isobutylene-alternative co-maleic anhydride) membranes

Ion exchange membranes with carboxyl groups, which were insoluble in acidic and alkaline aqueous solutions, were prepared from poly(isobutylene-alternative co-maleic anhydride) and poly(vinyl alcohol). When a membrane, one side of which was alkaline, the other, acidic, was fixed in a diaphragm cell, it transported organic ions, such as amino acids and aniline, from the acidic to the alkaline side or vice versa. The passage of organic ions through the membrane was governed by an electrochemical interaction between carboxyl groups in the membrance and transporting ions. The direction of the organic ions depended on a pH difference between the two sides of the membrane.     

Innovative instrumental analysis of heartbeat signals and its clinical application

A new apparatus has been built that annexes a normal electrocardiograph, ECG, with the aim to enhance its capacity. It adds the normal ECG power to superpose multiple records of ECG altogether and averages out them and, further, makes sophisticated analysis, such as normalizing the peak heights, evaluating the half-line widths of the peaks, or that of the standard deviations of measurements like the inter peak distances. The results of the said calculations have not been obtainable using the former instruments, and are expected to be useful for clinicians.     

Strahlungschemische Untersuchungen von Proteln-Reaktionen: Einflu? der Atmosph?re und der Temperatur bei der Bestrahlung auf die optische Drehung

Ohne Zusammenfassung     

In situ photolysis of CD3I in solid orthodeuterium

Photochemical reactions of molecules in solid orthodeuterium (o-D2) have been studied by high-resolution infrared spectroscopy and compared with previous results obtained in solid parahydrogen (p-H2). Ultraviolet photolysis of CD3I molecules in solid o-D2 yielded CD3 radicals and iodine atoms efficiently, which indicates a small cage effect in solid o-D2, as in the case of solid p-H2. The Fourier transform infrared spectrum of the nu3 vibrational band of CD3 showed a rotational structure with additional splitting due to crystal field interactions. The magnetic dipole transition (2P1/2<--2P3/2) of the I atom isolated in solid o-D2 was observed together with a strong rotational satellite of deuterium molecules through the electron-roton coupling in solid hydrogen. The tunneling reaction between CD3 and D2 was not observed in a time scale of a few days, which gives the upper limit of the tunneling reaction rate of 10(-8) s(-1) at 4.2 K.     

Labeling of alprenolol with fluorescent aryl iodide as a reagent based on Mizoroki-Heck coupling reaction

A novel fluorescent labeling method for alprenolol was developed based on Mizoroki-Heck coupling reaction. We designed and synthesized fluorescent aryl iodide, 4-(4,5-diphenyl-1H-imidazol-2-yl)iodobenzene (DIBI) as a labeling reagent. DIBI has a lophine skeleton carrying an iodide atom acting as fluorophore and reactive center, respectively. In order to evaluate the usefulness of DIBI, a high-performance liquid chromatography (HPLC) with fluorescence detection method was developed for the determination of alprenolol as a model compound of terminal double bond. The fluorescent labeling of alprenolol with DIBI was achieved in the presence of palladium acetate as a catalyst, and the labeled alprenolol was detected fluorometrically. In addition, it was found that the fluorescence of DIBI derivative increased and red shifted when compared with that of DIBI. Furthermore, the proposed method could be applied to determine the alprenolol concentration in rat plasma after administration of alprenolol without interferences from biological components. The detection limit (S/N=3) for alprenolol in rat plasma was 0.74 ng/mL (30 fmol on column).