Short Total Synthesis of Ajoene, (E,Z)-4,5,9-Trithiadodeca-1,6,11-triene 9-oxide,in Batch and (E,Z)-4,5,9-Trithiadodeca-1,7,11-triene in Continuous Flow

A short total synthesis of ajoene, (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide, has been achieved over six steps. In addition, a continuous flow synthesis under mild reaction conditions to (E,Z)-4,5,9-trithiadodeca-1,7,11-triene is described starting from simple and easily accessible starting materials. Over four steps including propargylation, radical addition of thioacetate, deprotection, and disulfide formation/ allylation, the target product can be obtained at a rate of 0.26 g h⁻¹ in an overall yield of 12 %.     

Radical cyclopolymerization of dimethacrylates bearing rigid adamantane-like core derived from naturally occurring myo-inositol

Dimethacrylates with rigid adamantane-like cores were synthesized from myo-inositol orthoester via a sequence of (a) acylation or silylation of the equatorially oriented hydroxyl group, followed by (b) attachment of methacrylate groups on the axially oriented hydroxyl groups. The radical homopolymerization of these compounds proceeded via cyclopolymerization without crosslinking, as the two axially oriented methacrylate groups were fixed in close proximity with each other. The dimethacrylates underwent radical copolymerization with methyl methacrylate (MMA) to afford the corresponding polymethacrylates, exhibiting high glass transition temperatures (T_g), due to the introduction of the rigid orthoester moieties originating from the monomers and the macrocyclic structures formed via intramolecular cyclization of the two methacrylate groups of the monomers. The polymers obtained by polymerization of the dimethacrylate bearing a silylated hydroxyl group served as precursors of hydroxyl-bearing polymers, which also exhibited high T_g due to the formation of a hydrogen bonding network between the hydroxyl groups.     

Solutions with time-dependent singular sets for the heat equation with absorption

We consider the heat equation with a superlinear absorption term ${?}_{t}u?\mathrm{\Delta }u=?u^p$ in ${\mathbb{R}}^n$ and study the existence of nonnegative solutions with an m-dimensional time-dependent singular set, where $n?m\ge 3$. We prove that if $1<p<(n?m)/(n?m?2)$, then there are two types of singular solutions. Moreover, we show the uniqueness of the solutions and specify the exact behavior of the solutions near the singular set.     

The119Sn Mössbauer effect in RMn6Sn6 compounds (R=Gd,Y)

The magnetic properties of intermetallic compounds RMn₆Sn₆ (T=Gd and Y) have been investigated by¹¹⁹Sn Mössbauer effect measurements. The differences of the hyperfine field on both the Sn₁ and Sn₃ sites were small between GdMn₆Sn₆ and YMn₆Sn₆, while the Mn sublattice orders ferromagnetically for R=Gd and antiferromagnetically for R=Y. This result indicated that Mn moments order antiferromagnetically in the intra-plane of the Kagomè net in YMn₆Sn₆.     

Adding visualization functions of DAVIS to Jasp: Mixing two Java-based statistical systems

Summary  Jasp is an experimental general purpose Java-based statistical system which adopts several new computing technologies. It has a function-based and object-oriented language, an advanced user interface, flexible extensibility and a server/client architecture with distributed computing abilities. DAVIS is, on the other hand, a stand-alone Java-based system, and is designed for providing advanced data visualization functions with easy operations by a GUI. In this paper, it is made possible to use tools of DAVIS from within Jasp, in order that the new integrated system can handle not only data filtering and statistical analysis but also data visualization. We develop a mechanism for extending the server/client system of Jasp to realize an efficient collaboration with DAVIS in the client-side. It is shown that the mechanism is straightforward and simple.     

Molecular design of potent inhibitor specific for cathepsin B based on the tertiary structure prediction.

To design a potent inhibitor specific for cathepsin B (rat liver), the tertiary structure was predicted based on the crystal structure of the papain complexed with (+)-(2S,3S)-3-(1-[N-(3-methylbutyl)amino]leucylcarbonyl)oxirane-2- carbolylic acid (E-64-c), a thiol protease inhibitor. Taking advantage of the structural characteristics of the predicted active site, seventeen inhibitors were chemically synthesized by molecular modeling, and one of them, N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-p rol ine (CA-074) was shown to be the first potent inhibitor specific for cathepsin B. The relationship between the structure and inhibitory activity is discussed based on the model structure of the cathepsin B-inhibitor complex.     

Effect of calcination temperature during preparation of Ru?Sn-alumina catalysts on the hydrogenation of carboxylic acid

The conversion of a carboxylic acid was increased to 90% with 100% selectivity to the corresponding alcohol by calcination of the catalyst precursor, Sn/alumina, of Ru–Sn/alumina in the hydrogenation of the carboxylic acid.     

On a dendrite generated by a zero-dimensional weak self-similar set

Let S be a zero-dimensional, perfect, compact weak self-similar set generated in dendrite X by a family {f_j} of weak contractions from X to itself. Decomposition space D_f of S due to a continuous mapping f from S onto X is also a dendrite. In the dendrite D_f, there exists a zero-dimensional, perfect, compact weak self-similar set S¹ based on a family each of which is topologically conjugate to f_j. Decomposition space D_f¹ of S¹ due to a continuous mapping f¹ from S¹ onto D_f is again a dendrite. In this manner, through the successive formation of weak self-similar set, we can obtain a sequence X,D_f,D_f¹,… of dendrite any pair in which are mutually homeomorphic.