2-chloro-3,3,5-trimethyl-2,3-dihydro-1,2λ5-oxaphosphole 2-oxide as precursor in a new synthesis of dialkyl(diaryl)-(2-methyl-4-oxopent-2-yl)phosphine oxides

A new approach has been developed to the synthesis of dialkyl(diaryl)(2-methyl-4-oxopent-2-yl)-phosphine oxides that are structural analogs of the drug dimephosphon. This approach is based on the reaction of 2-chloro-3,3,5-trimethyl-3H-1,2λ⁵-oxaphosphole 2-oxide with Grignard compounds, and it ensures high yields of the target products. The structure of bis(2-methoxyphenyl)(2-methyl-4-oxopent-2-yl)phosphine oxide was determined by X-ray analysis. (2-Methyl-4-oxopent-2-yl)dipropylphosphine oxide with magnesium bromide formed a 4: 1 complex whose structure was also determined by X-ray analysis.     

Synthesis,properties, and antianemic activity of new metal complexes of sodium pectinate with iron and calcium

A new water-soluble complex based on sodium pectinate with iron and calcium (P-NaFeCa) was synthesized. The regularities of the complexation of sodium pectinate (with a 35% content of COONa groups) with biogenic metals Ca and Fe were studied. The content of macro- and microelements was determined by atomic emission spectrometry; the product was identified by IR spectroscopy. Using atomic force microscopy, it was found that the average particle size of P-NaFeCa is ~170 nm. The efficiency of P-NaFeCa (per os) was studied for the first time in animals with hemolytic anemia modeled by administration of phenylhydrazine. It was experimentally shown that in vivo P-NaCaFe at a dose of 60 mg kg^–1 containing 50% of the recommended therapeutic dose of iron helps to recover the number of erythrocytes and mean concentration hemoglobin in erythrocyte, which indicates the efficiency of P-NaCaFe as an agent restoring the blood parameters after exposure to hemolytic poisons.

     

Features of Reaction of 2-(5-Methyl-2-phenyl-2<Emphasis Type="Italic">H</Emphasis>-1,2,3-diazaphosphol-4-yl)-4<Emphasis Type="Italic">H</Emphasis>-benzo[<Emphasis Type="Italic">e</Emphasis>]-1,3,2-dioxaphosphorin-4-one with 1,2-Dicarbonyl Compounds

2-(5-Methyl-2-phenyl-2H-1,2,3-diazaphosphol-4-yl)-4H-benzo[e]-1,3,2-dioxaphosphorin-4-one reacts with perfluorodiacetyl, 3,6-di(tert-butyl)-1,2-benzoquinone and phenanthrenequinone only with the participation of a three-coordinated phosphorus atom to form spirophosphoranes containing acyclic 5-methyl-2- phenyl-2H-1,2,3-diazaphosphol-4-yl substituent, whereas the interaction with tetrachloro-1,2-benzoquinone proceeds via expanding the six-membered heterocycle to the nine-membered one to form 2-(2-phenyl-2H-1,2,3-diazaphosphol-4-yl)-2,9-dioxo-4,5,6,7-tetrachlorodibenzo[d,h]-1,3,8-trioxaphosphonine.     

Reactions of 2-(5-methyl-2-phenyl-2H-1,2,3-diazaphosphol-4-yl)- 4H-1,3,2-benzodioxaphosphinin-4-one with chloral and hexafluoroacetone

Reaction of 2-(5-methyl-2-phenyl-2H-1,2,3-diazaphosphol-4-yl)-4H-1,3,2-benzodioxaphosphinin-4-one with chloral occurs at Piii atom of the 1,3,2-dioxaphosphinine cycle giving mostly 2-chlorocarbonylphenyl 2,2-dichlorovinyl (5-methyl-2-phenyl-2H-1,2,3-diazaphosphol-4-yl)phosphonate, whereas hexafluoroacetone incorporates into the 1,3,2-dioxaphosphorine cycle affording the corresponding 1,3,2-benzodioxaphosphepine.     

Fused polycyclic nitrogen-containing heterocycles 24. Three-component condensation of diethyl 2,4,6-trioxoheptanedicarboxylate with salicylaldehydes and ammonium acetate as a new method for the synthesis of 7- and 9-substituted benzo[e]pyrano[4,3-b]pyridines

The three-component condensation of diethyl 2,4,6-trioxoheptanedicarboxylate with salicylaldehyde and its 3,5-dichloro-, 3-methoxy-, and 5-methoxy-substituted derivatives in EtOH in the presence of ammonium acetate affords tricyclic products, viz., tetrahydrobenzo[e]-pyrano[4,3-b]pyridines. In the reaction with 3-nitrosalicylaldehyde, the intramolecular closure of the pyran ring does not occur due to the deactivation of the hydroxy group by the nitro group, and this reaction stops at the formation of the monocyclic product, viz., tetrahydropyridin-4-one.     

Solution of the boundary value problem for the Navier-Stokes equation for the flow of a gaseous medium past a heated spheroid

We find the solution of the Navier-Stokes equation linearized with respect to the velocity with regard of a power-law dependence of the molecular transport coefficients (viscosity and heat conductivity) and the gaseous medium density on the temperature. The uniqueness of the solution is proved.     

Acoustic flow in the resonator throat: Experiment and computational modeling

This paper is devoted to the study of acoustic flow in the Helmholtz resonator throat. The presented results of a complex investigation on the basis of data of a physical experiment and a mathematical modeling, their comparative analysis, and comparison with theoretical estimations provide a rather complete image of the acoustic flow formation and, in particular, enable one to obtain qualitative and quantitative dependences of the averaged velocity component in the resonator throat at different powers of an exciting sound wave.     

Nontraditional ordered structures in condensed-matter physics

The so-called nontraditional ordered crystal systems are of particular interest between other ordered systems. With respect to their structure and properties, they are connecting links between the three main groups of condensed matter: periodic systems, aperiodic systems (partially or completely disordered), and biopolymers and living matter.