Changes in cerebral activity after decreased upper-limb hypertonus: an EMG-fMRI study

Objective

Whereas several studies have used functional magnetic resonance imaging (fMRI) to investigate motor recovery, whether therapy to decrease post-stroke hypertonus alters central motor patterns remains unclear. In this study, we used continuous electromyography (EMG)-fMRI to investigate possible changes in movement-related brain activation in patients receiving Botulinum toxin (BoNT-A) for hand-muscle hypertonus after chronic stroke.

Methods

We studied eight stroke patients all of whom had hemiparesis and associated upper-limb hypertonus. All patients underwent an fMRI-EMG recording and clinical-neurological assessment before BoNT-A and 5 weeks thereafter. The handgrip motor task during imaging was fixed across both patients and controls. The movements were metronome paced, movement amplitude and force were controlled with a plastic orthosis, dynamometer and EMG recording. An age-matched control group was recruited from among healthy volunteers underwent the same fMRI-EMG recording.

Results

Before BoNT-A, while patients moved the paretic hand, fMRI detected wide bilateral activation in the sensorymotor areas (SM1), in the supplementary motor area (SMA) and cerebellum. After BoNT-A blood oxygenation level-dependent (BOLD) activation decreased in ipsilateral and contralateral motor areas and became more lateralized. BOLD activation decreased also in ipsilateral cerebellar regions and in the SMA.

Conclusion

Changes in peripheral upper-limb hypertonus after BoNT-A were associated to an improvement in active movements and more lateralized and focalized activation of motor areas. The clinical and EMG-fMRI coregistration technique we used to study hand-muscle hypertonus in patients receiving BoNT-A after chronic stroke should be useful in future studies seeking improved strategies for post-stroke neurorehabilitation.     

Well-Posedness for Nonlinear Wave Equation with Potentials Vanishing at Infinity

The main purpose of this paper is to prove global well-posedness in some scale-invariant weighted Besov spaces and Strichartz spaces for the nonlinear wave equation with competing nonlinearities which have time depending potentials decaying at infinity. We discuss also some new frequency localized estimates in non-isotropic Lebesgue spaces.     

Bases of Feigin–Stoyanovsky’s type subspaces for $$C_\ell ^{(1)}$$

In this paper, we construct combinatorial bases of Feigin–Stoyanovsky’s type subspaces of standard modules for level k affine Lie algebra \(C_\ell ^{(1)}\). We prove spanning by using annihilating field \(x_\theta (z)^{k+1}\) of standard modules. In the proof of linear independence, we use simple currents and intertwining operators whose existence is given by fusion rules.     

Maps from M2({\mathbb{F}}) to M3({\mathbb{F}}) that are multiplicative with respect to the Jordan triple product

We characterize the Jordan triple product preserving maps M₂( ${\mathbb{F}}$ ) to M₃( ${\mathbb{F}}$ ) for algebraically closed fields ${\mathbb{F}}$ , char ${\mathbb{F} \neq 2}$ .     

On bipartite graphs with small number of laplacian eigenvalues greater than two and three

All connected bipartite graphs with exactly two Laplacian eigenvalues greater than two are determined. Besides, all connected bipartite graphs with exactly one Laplacian eigenvalue greater than three are determined.     

Optical parametric generation of nearly transform-limited mid-infrared pulses in dispersion-engineered nonlinear waveguides

Optical parametric generation in dispersion-engineered waveguides fabricated by proton exchange in periodically poled lithium niobate is numerically investigated as a means for producing widely tunable mid-infrared ultrashort pulses starting from low energy pump pulses at a 1.55 mum wavelength and with 100 fs duration, which are typical parameters of amplified Er-fiber oscillators. Numerical evidence is given about the generation of sub-100 fs nearly transform-limited pulses in the 2.4-4.4 mum spectral range.     

The rate matching effect: A hidden property of aperiodic stochastic resonance

We study a system S generating Poisson events, and a corresponding dichotomous signal as well, perturbed by a system P, also generating Poisson events and a corresponding dichotomous signal. The rates of events productions for system and perturbation are gS and gP, respectively. We call S events the events produced by the system S and P events those produced by the perturbation P. We show that this simple model reproduces the essence of recent experimental and theoretical results on aperiodic stochastic resonance. More remarkably, this simplified version of aperiodic stochastic resonance allows us to discover a property that has been overlooked by the earlier research work. The rate matching condition gS=gP is the border between two distinctly different conditions: For gS<gP, the P events are attractors of the S events and for gS>gP they become repellers of the S events. The transition from the former to the latter condition is very marked and takes place in a short region of either gS or gP, depending on which is the parameter changed, thereby resulting in a discontinuous transition.     

Use of Nitrogen-Doped Carbon Nanodots for the Photocatalytic Fluoroalkylation of Organic Compounds

The use of amine-rich N-doped carbon nanodots (NCNDs) for the photochemical radical perfluoroalkylation of organic compounds is reported. This operationally simple approach occurs under mild conditions producing valuable new C−C bonds. The chemistry is driven by the ability of NCNDs to directly reach an electronically excited state upon light absorption, thereby successively triggering the formation of reactive radical species from simple perfluoroalkyl iodides. Preliminary mechanistic studies are also reported.     

NMR-based differentiation of conventionally from organically produced chicken eggs in Germany

Both the German and European organic food markets are growing fast, and there is also a rising demand for organic chicken eggs. Consumers are willing to pay higher prices for organic eggs produced in an animal-appropriate environment considering animal welfare. Strict labelling requirements do not prevent chicken eggs from being a subject of food fraud. Conventionally produced (barn/free-range) eggs can easily be mislabeled as organic eggs. Especially because the demand for organically produced chicken eggs is likely to exceed supply in the future, mislabeling appears to be a realistic scenario. Therefore, there is a need for analytical methods that are suitable to classify eggs as being either conventionally or organically produced. Nuclear magnetic resonance (NMR) spectroscopy in combination with multivariate data analysis is a suitable tool to screen eggs according to the different systems of husbandry. Sample preparation is based on a fat extraction method, which was optimised for application to freeze-dried egg yolk. Samples were analysed using typical q-NMR parameters. A nontargeted approach was used for the analysis of the ¹H NMR data. Principal component analysis (PCA) was applied followed by a linear discriminant analysis (PCA-LDA) and Monte Carlo cross-validation. In total, 344 chicken eggs (214 barn/free-range eggs and 130 eggs from organic farms), most of them originating from Germany, were used to build and validate the prediction model. The results showed that the prediction model allowed for the correct classification of about 93% of the organic eggs.