Three-layer composite magnetic nanoparticle probes for DNA

A method for synthesizing composite nanoparticles with a gold shell, an Fe3O4 inner shell, and a silica core has been developed. The approach utilizes positively charged amino-modified SiO2 particles as templates for the assembly of negatively charged 15 nm superparamagnetic water-soluble Fe3O4 nanoparticles. The SiO2-Fe3O4 particles electrostatically attract 1-3 nm Au nanoparticle seeds that act in a subsequent step as nucleation sites for the formation of a continuous gold shell around the SiO2-Fe3O4 particles upon HAuCl4 reduction. The three-layer magnetic nanoparticles, when functionalized with oligonucleotides, exhibit the surface chemistry, optical properties, and cooperative DNA binding properties of gold nanoparticle probes, but the magnetic properties of the Fe3O4 inner shell.     

Strategies for Organizing Nanoparticles into Aggregate Structures and Functional Materials

In this review, we focus on some of the most successful approaches to date for organizing nanoparticles into macroscopic aggregates and functional materials. The preparation and resulting properties of two- and three-dimensional arrays of nanoparticles are detailed, and some potential uses for these materials are discussed. Although many types of nanoparticles can be organized into such structures, this review focuses specifically on Au and CdE (E=S, Se) nanoparticles. Gold nanoparticles are easily prepared, highly stable, well-studied, and excellent models for other metal colloids. CdE colloids are the most extensively studied semiconductor nanoparticles and hold much promise in the optoelectronics field.