Spin-dependent Andreev reflection in a three-terminal Aharonov-Bohm interferometer with coherent indirect coupling

Within the framework of non-equilibrium Green’s functions, we investigate the spin-dependent Andreev reflection (AR) in a three-terminal Aharonov-Bohm interferometer with double quantum dot, taking account of the coherent indirect coupling via the superconducting reservoir. It is found that the time-reversal symmetry is broken by the crossed Andreev reflection (CAR) process, and moreover that the spin-value effect of the linear conductance, the spin-polarised AR current, and a pure spin current can be generated by means of the normal AR and the CAR. Expressions for the AR conductances (the transport coefficients) governing the AR properties of this system are derived analytically. The effect of the coherent indirect coupling on the conductance, the Andreev reflected tunneling magnetoresistance (ARTMR), and the spin-related current in the presence of the AR are amply analyzed. Our results indicate that the optimal properties of this system can be realised by tuning the external parameters.     

Attenuation correction for dedicated breast PET using only emission data based on consistency conditions

Accurate attenuation correction is required in dedicated breast PET imaging systems for image artifact removal and quantitative studies. In this study, a method using only emission data based on consistency conditions is proposed for attenuation correction in breast PET imaging systems. The consistency conditions are exploited to evaluate the accuracy of the estimated attenuation distribution and find the appropriate parameters that yield the most consistent attenuation distribution with the measured emission data. We have proved the validity of the method with experimental investigations and single-patient studies using a dedicated breast PET. The results show that the method is capable of accurately estimating the attenuation distribution of a uniform attenuator from the experimental data with various relatively low activities. The results also show that in single-patient studies, the method is robust for the irregular boundary of breast tissue and provides a distinct improvement in image quality.     

On the constitutive relations for isotropic and transversely isotropic materials

In this work the strain and stress spaces constitutive relations for isotropic and transversely isotropic softening materials are developed. The loading surface is considered in the strain space and the normality rule; the stress relaxation is proportional to the gradient of the loading surface, is adopted. It is found that the strain space plasticity theory allows us to describe the hardening, perfectly plastic and softening materials more accurately. The validity of the strain space constitutive relation for transversely isotropic materials are confirmed by comparing with the experimental data for fiber reinforced composite materials. Some numerical examples in two and three dimensional elasto-plastic problems for various loading–unloading conditions are presented, and give a very good agreement with the existing results.     

Consistency analysis of the spectrum and prosody within a syllable for Mandarin speech

This work presents a study of Mandarin speech focusing on consistency analysis of the spectrum and prosody within syllables. Identified as a result of inspection of the human pronunciation process, this consistency can be interpreted as a high correlation between the warping curves of the spectrum and the prosody intra a syllable. The consistency analysis consisted of three steps. First, the hidden Markov model algorithm was used to decode the hidden Markov model‐state sequences within a syllable, while at the same time dividing them into three segments. Second, based on a designated syllable, the vector quantization (VQ) with the Linde–Buzo–Gray algorithm was employed to train the VQ codebooks of the prosodic vector of each segment. Third, the prosodic vector of each segment was encoded as an index using the VQ codebooks, and then, to analyze the consistency, the probability of each possible path was evaluated as a prerequisite. Finally, two syllables were used as examples to verify the consistency property found in the experiments. It is demonstrated experimentally that there is definitely consistency in the case where the syllable is located in exactly the same word. These results offer a research direction in that the warping process between the spectrum and the prosody intra a syllable must be considered in text‐to‐speech systems to improve the synthesized speech quality. Copyright © 2013 John Wiley & Sons, Ltd.     

Long paths and cycles in subgraphs of the cube

Let Q _n denote the graph of the n-dimensional cube with vertex set {0, 1} ⁿ in which two vertices are adjacent if they differ in exactly one coordinate. Suppose G is a subgraph of Q _n with average degree at least d. How long a path can we guarantee to find in G? Our aim in this paper is to show that G must contain an exponentially long path. In fact, we show that if G has minimum degree at least d then G must contain a path of length 2 ^d ? 1. Note that this bound is tight, as shown by a d-dimensional subcube of Q _n . We also obtain the slightly stronger result that G must contain a cycle of length at least 2 ^d .     

Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor

Prevention of aggregation is critical for analyzing protein structure. Non-detergent sulfobetaines (NDSBs) are known to prevent protein aggregation, but the molecular mechanisms of their anti-aggregation effect are poorly understood. To elucidate the underlying mechanisms, we analyzed the effects of dimethylethylammonium propane sulfonate (NDSB-195) on acidic fibroblast growth factor (aFGF). NDSB-195 (0.5M) increased both aggregation and denaturation temperatures of aFGF by 4 degrees C. Chemical shift perturbation analyses indicated that many affected residues were located at the junction between a beta-strand (or 3(10)-helix) and a loop, irrespective of the chemical properties of the residue. The apparent dissociation constants of the interaction ranged from 0.04 to 3M, indicating weak interactions between NDSB and protein molecules.     

Solid‐state nuclear magnetic resonance investigation of neurosteroid compounds and magnesium interactions

The neurosteroid trans‐dehydroandrosterone (DHEA) and its analogs with slightly different modifications in the side chain attached to C17, that is, (3S)‐acetoxypregn‐5‐en‐20‐one ( 1 ) and (3S,20R)‐acetoxypregn‐5‐en‐20‐ol ( 2 ), have been synthesized to investigate DHEA–cation interactions. In this study, we applied solid‐state ¹H/¹³C cross‐polarization/magic‐angle spinning (CP/MAS) nuclear magnetic resonance (NMR) spectroscopy to a series of DHEA analog/Mg²⁺ mixtures at different Mg²⁺ concentrations. The high‐resolution ¹³C NMR spectra of 1 /Mg²⁺ mixtures exhibit two distinct ¹³C spectral patterns, one attributable to 1 free from Mg²⁺, and the other attributable to 1 with bound Mg²⁺. For 2 , the ¹³C NMR spectra exhibit three distinct spectral patterns; besides that of the free form, the other two can be assigned to Mg²⁺‐bound forms. Based on the analysis of the chemical shift deviations (CSDs), we conclude that both 1 and 2 might be subject to a cation–π interaction via the C5–C6 double bond, in contrast to that observed previously for DHEA. As demonstrated, DHEA possesses two Mg²⁺ binding sites, that is, C17–O and C5–C6 double bond, in which the binding affinity of the former is at least three times stronger than that of the latter. The solid‐state ¹³C NMR investigation allows better understanding of the underlying cation binding effects of neurosteroid molecules in vitro.     

Organic base-promoted efficient dehydrogenative/decarboxylative aromatization of tetrahydro-β-carbolines into β-carbolines under air

Organic base DBN has been identified as an efficient reagent for promoting the dehydrogenative/decarboxylative aromatization of tetrahydro-β-carbolines under air atmosphere, to access the corresponding β-carbolines in moderate to good yields. The utility of this protocol for the gram-scale synthesis of β-carboline alkaloids eudistomin U (7) and harmane (10) has also been demonstrated.