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Takashi Kudoh Andreas H. Guse Minako Hashii Mitsuhiro Arisawa Satoshi Shuto 《Tetrahedron letters》2008,49(25):3976-3979
4″,6″-Didehydro-cADPcR (3), an unsaturated carbocyclic ribose analog of a Ca2+-mobilizing second messenger cyclic ADP-ribose (cADPR), was designed and successfully synthesized using a key intramolecular condensation reaction forming the 18-membered pyrophosphate ring structure with a S-phenyl phosphorothioate-type substrate. Biological evaluation showed that 4″,6″-didehydro-cADPcR is a potent Ca2+-mobilizing agent in T cells. 相似文献
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2-Methylthio-4-alkenoic esters prepared from 1-alkenes and ethyl methylsulfinylacetate are converted into α,β-unsaturated esters via hydrogenation, oxidation, and thermolysis. This method was applied to the synthesis of queen substance. 相似文献
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Harano A Tanaka M Nakagaki T Annaka M Ideta K Goto K Shinmyozu T 《Organic & biomolecular chemistry》2011,9(10):3611-3614
The novel tetrahedral macrocycles 1a-1c have been synthesized. Macrocycles 1a and 1c were revealed to have the property to increase in volume in solution by complexation between the macrocycle and the solvent molecules. 相似文献
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Hideo?AkisadaEmail author Junko?Kuwahara Minako?Kunisaki Keiko?Nishikawa Shiho?Akagi Mituyo?Wada Ayano?Kuwata Sakiko?Iwamoto 《Colloid and polymer science》2004,283(2):169-173
The interaction between MEGA-10 and surface active agents was studied by means of circular dichroism. The molecular ellipticity of MEGA-10 varied with the addition of surface active agents, but its peak wavelength did not. The carbonyl group of MEGA-10 did not interact with the nonionic surface active agents nor the catanionic surfactant (of which the anionic and cationic portions were decanesulfonate and decyltrimethylammonium, respectively). It did, however, interact with the ionic surfactants, and also strongly with the ammonium group and the benzene ring. The interaction between MEGA-10 and ionic surfactant charges did not differ according to the sign of the charge. Circular dichroism spectra are a useful tool for performing research into the interaction between an optically active carbonyl group and an additive. 相似文献
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To examine a dynamic interaction between nucleotide and cyclic oligosaccharide, ultrasonic absorption measurements were carried out in aqueous solution containing beta-cyclodextrin (beta-CD) and adenosine 5'-monophosphate (AMP) in the frequency range of 0.8-95 MHz. A relaxational absorption was observed in the solution, although it was not found in the individual solution of beta-CD or AMP. From the concentration dependences of AMP on the relaxation time and the maximum absorption per wavelength, the cause of the relaxation was attributed to a perturbation of a chemical equilibrium associated with a complex formation between beta-CD (host) and AMP (guest). The rate constants for the formation and breakup processes of the complex were determined. Also, a standard volume change of the reaction was obtained. From comparisons of the obtained rate and thermodynamic parameters with those for beta-CD and various guests, it has been concluded that the adenine moiety is included in the beta-CD cavity and that the hydrogen bonds may play a role in the complex formation. 相似文献
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Photochemical welding of silica microspheres to silicone rubber by ArF excimer laser 总被引:1,自引:0,他引:1
Transparent fused silica (SiO2) microspheres 2.5 μm in diameter were photochemically welded to transparent, flexible silicone rubber ([SiO(CH3)2]n) substrate by 193 nm ArF excimer laser induced photochemical modification of silicone into silicon oxide. Single layer of silica microspheres was easily formed on an adhesive silicone rubber before laser irradiation after dropping of silica microspheres dispersed in ethanol and subsequent tape peeling. The welding rate, the percentage of welded microspheres tested by ultrasonic cleaning with ethanol, was examined by varying the single pulse fluence and irradiation time of ArF excimer laser. The welding layer underneath microsphere, silicon oxide, was also found to emit white light of strong intensity under UV light illumination. 相似文献
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Aoki T Hirano M Takeuchi Y Kobayashi T Yanagida T Ide T 《Proceedings of the Japan Academy. Series B, Physical and biological sciences》2010,86(9):920-925
Single channel currents of lysenin were measured using artificial lipid bilayers formed on a glass micropipette tip. The single channel conductance for KCl, NaCl, CaCl(2), and Trimethylammonium-Cl were 474 ± 87, 537 ± 66, 210 ± 14, and 274 ± 10 pS, respectively, while the permeability ratio P(Na)/P(Cl) was 5.8. By adding poly(deoxy adenine) or poly(L-lysine) to one side of the bilayer, channel currents were influenced when membrane voltages were applied to pass the charged molecules through the channel pores. Current inhibition process was concentration-dependent with applied DNA. As the current fluctuations of α-hemolysin channels is often cited as the detector in a molecular sensor, these results suggest that by monitoring channel current changes, the lysenin channel has possibilities to detect interactions between it and certain biomolecules by its current fluctuations. 相似文献