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141.
Novel complexes of type [Cu(N-N)(dmtp)2(OH2)](ClO4)2·dmtp ((1) N-N: 2,2′-bipyridine; (2) L: 1,10-phenantroline and dmtp: 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine) were designed in order to obtain biologically active compounds. Complexes were characterized as mononuclear species that crystallized in the space group P-1 of the triclinic system with a square pyramidal geometry around the copper (II). In addition to the antiproliferative effect on murine melanoma B16 cells, complex (1) exhibited low toxicity on normal BJ cells and did not affect membrane integrity. Complex (2) proved to be a more potent antimicrobial in comparison with (1), but both compounds were more active in comparison with dmtp—both against planktonic cells and biofilms. A stronger antimicrobial and antibiofilm effect was noticed against the Gram-positive strains, including methicillin-resistant Staphylococcus aureus (MRSA). Both electron paramagnetic resonance (EPR) and Saccharomyces cerevisiae studies indicated that the complexes were scavengers rather than reactive oxygen species promoters. Their DNA intercalating capacity was evidenced by modifications in both absorption and fluorescence spectra. Furthermore, both complexes exhibited nuclease-like activity, which increased in the presence of hydrogen peroxide.  相似文献   
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The existence of a short C–H ⋯ π (alkyl–alkyne) interaction in the structure of a strained and relatively rigid tolanophane is expected to hinder the rotation about the C–C sp3 single bond. Variable-temperature NMR experiments (performed in three solvents, CDCl3, THF-d8, and acetone-d6) and ab initio density functional calculations were carried out to investigate its dynamic nature. An energy barrier of 48.6 kJ/mol is determined at coalescence (210 K) with acetone-d6 which is in good agreement with calculation result (54 kJ/mol). Correspondence: Hossein Reza Darabi, Chemistry and Chemical Engineering Research Center of Iran, Pajoohesh Blvd., km 17, Karaj Hwy, 14968-13151 Tehran, Iran.  相似文献   
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Using combinatorial methods, we classify all birational morphisms blowingm ≦ 5 divisors down to a point. Those which do not factor through the blowing up of a point are treated in the body of the paper, and the factorizable morphisms are computed in an appendix. The relevance of this classification to the determination of the nature of the “general” toric morphism is discussed.  相似文献   
146.
beta-Nitroenamines having a formyl group at the beta-position behave as the synthetic equivalent of unstable nitromalonaldehyde, which is a useful synthon for syntheses of versatile nitro compounds. High solubility of the nitroenamines into general organic solvents enables us to conduct reactions in the organic media accompanied by easy experimental manipulations and considerable safety. When nitroenamines are treated with 1,2-bifunctional nucleophiles such as hydrazines, hydroxylamine and glycine ester, nitrated pyrazoles, isoxazole and pyrrole-2-carboxylate were readily prepared. This methodology was also applicable to guanidines and 1,2-diamines, leading to pyrimidines and 1,4-diazepines, respectively.  相似文献   
147.
The 22 K sub-bands, belonging to the v 1 + v ±1 6, v 3 + v ± 5 + 2v 0 6 and v 3 + v ±1 5 + 2v ±2 6 rovibrational bands of monoisotopic CH3 79Br, have been identified. An RMS standard deviation of about 0·020 cm-1 has been achieved by a least squares fit over 619 lines belonging to these 22 sub-bands. For this purpose, a model taking into account (a) anharmonic resonances between (i) v 1 + v ±1 6, and v 3 + v ±1 5 + 2v 0 6, (ii) v 1 + v ±1 6 and v 3 + v ?1 5 + 2v ±2 6 and (iii) v 3 + v ±1 5 + 2v 0 6 and v 2 + 2v 3 + v ±1 5 and (b) Coriolis resonances between the v 2 and v 5 modes, was used.  相似文献   
148.
In this study, cellulose nanoparticles were prepared by acid hydrolysis, separately conjugated with allicin and lysozyme by a carbodiimide cross-linker, and characterized by scanning electron microscopy, dynamic light scattering, and Fourier transform infrared spectroscopy. Then, their antimicrobial properties were evaluated by the microdilution method and compared with allicin, lysozyme, and nanocellulose alone. The results showed that nanocellulose had few antimicrobial activities, but allicin-conjugated nanocellulose (ACNC) and lysozyme-conjugated nanocellulose (LCNC) had good antifungal and antibacterial effects against standard strains of Candida albicans, Aspergillus niger, Staphylococcus aureus, and Escherichia coli. Noticeably, although allicin and lysozyme had different minimum inhibitory concentrations (MICs) against all strains, the same quantity of MIC50 and MIC90 was observed for both ACNC and LCNC. The authors suggest that both ACNC and LCNC can be used in industries as an antimicrobial agent in food packaging, inside foodstuffs, and in textile materials.  相似文献   
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We report the synthesis and characterization of new Ca(II) and Mg(II) complexes of the type [Ph―PPP]MR (M = Ca, R = N(SiMe3)2 ( 1 ); M = Mg, R = nBu ( 2 )) where Ph―PPP? is a tridentate monoanionic ligand (Ph―PPP―H = bis(2‐diphenylphosphinophenyl)phosphine). Reaction of the opportune metal precursor (Ca[N(SiMe3)2]2.THF2 or MgnBu2) with 1 equiv. of the pro‐ligand Ph―PPPH produces the corresponding calcium amido ( 1 ) or magnesium butyl ( 2 ) complex in high yield. Solution NMR studies show monomeric and kinetically stable structures for both species. The obtained complexes efficiently mediate the ring‐opening polymerization of ?‐caprolactone showing a turnover frequency of 40 000 h?1. In the presence of a hexogen alcohol, up to 2000 equiv. of monomer are converted by using a low loading of catalyst (5 µmol). Kinetic studies show a first‐order reaction in monomer concentration. Copyright © 2014 John Wiley & Sons, Ltd.  相似文献   
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