Toward the racemic total synthesis of hederacines A and B: construction of an advanced tricyclic intermediate

Progress toward the total synthesis of hederacines A and B is described. Our approach involves an allylic cyanate-to-isocyanate rearrangement, eneyne ring-closing metathesis, and a transannular reaction between the C-5 amino group and the C-12 position of the perhydroazuleno[5,6-b]furanone intermediate.     

Heilmittelchemische Nachweise und Bestimmungen

Ohne Zusammenfassung     

Synthesis and Photocatalytic Property of Hectorite/(Pt,TiO2) and H4Nb6O17/(Pt,TiO2) Nanocomposites

Abstract

TiO₂ and Pt have been intercalated in hectorite and H₄Nb₆O₁₇. The height of TiO₂ and Pt pillars was less than 0.8 nm and the band gap energy of TiO₂ pillars was ca. 3.3 eV. Both hectorite/TiO₂ and H₄Nb₆O₁₇(Pt, TiO₂) were capable of hydrogen evolution following irradiation from a high pressure mercury are (λ > 290 nm) in the presence of methanol as a sacrificial hole acceptor and the hydrogen evolution was enhanced by co-incorporation of Pt, although hectorite and hectorite/Pt did not show photocatalytic activity. Incorporation of Pt or Pt and TiO₂ in the interlayer of H₄Nb₆O₁₇ has resulted in enhanced photo evolution of hydrogen, however, TiO₂ alone in the interlayer of H₄Nb₆O₁₇ showed adverse photocatalytic activity.     

Functionalization of a simple dithienylethene via palladium-catalyzed regioselective direct arylation

The direct arylation on the thienyl groups of a diarylethene with various aryl iodides efficiently provided arylated dithienylethenes under palladium catalysis. Unsymmetrically substituted dithienylethenes were also synthesized by this protocol. This procedure allows a rapid access to a variety of aryl-substituted dithienylethenes from a single substrate of a simple dithienylethene.     

Reaction optimization using solid-phase catalysis-CD HTS: Nb-imidazoline-Cu(I)-catalyzed asymmetric benzoylation of 1,2-diols

Catalytic asymmetric benzoylation of 1,2-diols has been developed using a solid-phase asymmetric catalyst. The reaction conditions were optimized by the screening of different metal salts, solvents, bases, and temperatures. High-throughput screening was performed using circular dichroism detection, and the results revealed that Nb-imidazoline-copper(I) in combination with diisopropylethylamine was able to catalyze with high enantioselectivity, giving the monobenzoylated products in high yields and excellent enantiomeric excesses of up to 95% ee. [reaction: see text]     

Inelastic scattering on 12Be and disappearance of the N = 8 magic number

Experimental studies on in-beam γ-ray spectroscopy using a ¹²Be radioactive beam are presented. Inelastic scattering of the neutron-rich ¹²Be nucleus on ²⁰⁸Pb, ¹²C, and (CH₂)_n targets has been studied by measuring de-excitation γ-rays in coincidence with scattered particles. The level schemes and transition probabilities are determined for low-lying excited states in ¹²Be. The present paper presents a brief review of the spectroscopic results, which may be associated with the N = 8 shell quenching near the drip line. Received: 1 May 2001 / Accepted: 4 December 2001     

Experimental limits on the strength of weak neutral currents in lepton pair production at PETRA energies

The processes e⁺e^? → e⁺e^? and μ⁺μ^? have been studied at PETRA using the JADE detector. The data, which were collected at s-values of up to 1300 GeV² have been analysed in terms of an electro-weak extension of QED to obtain values for the weak vector and axial vector couplings in the lepton sector. The values obtained agree with the predictions of the standard Salam-Weinberg model and the data are further analysed in terms of this model to obtain the limits 0.10 < sin²?_w < 0.40 (68% CL). The mass of the neutral weak gauge boson is deduced to be greater than 51 GeV/c².     

Separative column atomizer for the direct determination of trace amounts of volatile elements by atomic absorption spectrometry

A novel atomizer effective for direct analysis was developed using a new type separative column atomizer (SCA) module. The SCA module incorporated an atomization part, a separation column and/or reaction column part and observation windows for atomic spectroscopic measurement. This module was applied to the direct analysis of trace amounts of mercury and cadmium in practical samples. No background absorption was observed on the thermal decomposition of synthesized samples in a starch matrix and human hair at the wavelengths of the analytical lines of Hg and Cd. The effectiveness of the technique for the determination of elemental compositions is evaluated.