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181.
Imao D Itoi A Yamazaki A Shirakura M Ohtoshi R Ogata K Ohmori Y Ohta T Ito Y 《The Journal of organic chemistry》2007,72(5):1652-1658
Diallyl 2-alkyl-2-arylmalonates underwent palladium-catalyzed decarboxylative allylation quickly under mild conditions. In contrast, no reaction took place with diallyl 2,2-dialkylmalonates under the same conditions. Electron-donating phosphine ligands were found to be vital for this reaction. Most of the solvents used did not affect the catalytic cycle. Catalysis in [bmim][BF4], a well-known ionic liquid, was inhibited as a result of formation of a hydrogen bond between a carboxylate anion and a [bmim]+ cation; however, the reaction in [bdmim][BF4], in which the acidic proton of [bmim][BF4] was replaced with a methyl group, proceeded smoothly. The catalytic mechanism was investigated using a tetradeuterated substrate and an enzymatically synthesized enantio-enriched allyl methyl 2-methyl-2-phenylmalonate. Even the electron-deficient phosphite ligand was found to be active for catalysis of diallyl 2-methyl-2-(2- or 4-nitrophenyl)malonates. 相似文献
182.
Noguchi T Tanaka N Nishimata T Goto R Hayakawa M Sugidachi A Ogawa T Asai F Fujimoto K 《Chemical & pharmaceutical bulletin》2007,55(10):1494-1504
A series of cinnamylindoline derivatives were synthesized, and their factor Xa (FXa) inhibitory activities and selectivity over trypsin were evaluated. Among them, some novel derivatives showed potent FXa inhibitory activities and good selectivity over trypsin. Especially, (E)-2-{5-[1-(acetimidoyl)piperidin-4-yloxy]-2-[2-(5-amidino-2-hydroxyphenyl)ethen-1-yl]indolin-1-ylsulfonyl}acetic acid (22f) having 2-hydroxycinnamyl moiety exhibited the most potent FXa inhibitory activity in vitro. Furthermore, 22f also exhibited potent anticoagulant activities in vitro. 相似文献
183.
AlCl(3) solution was analyzed at concentrations from 0.02 to 100 mM using an electrospray ionization quadrupole mass spectrometer (ESI-Q-MS), and the dissolution state of aluminum ions is discussed. Results obtained using ESI-Q-MS were consistent with those obtained using (27)Al nuclear magnetic resonance ((27)Al NMR). Aluminum species existed mainly as positively charged monomeric aluminum hydroxide coordinated with several water molecules in solution. The complexation of chloride ions by aluminum ions differed between the positive and negative ion modes. Chemical reactions that partially modified chemical forms of species through ESI-Q-MS measurement were also observed. In the same aluminum chloride solution, using ESI-TOF-MS and ESI-Q-MS/MS studies, the disagreement of the reports is discussed. It is concluded that ESI-TOF-MS might show also the gas-phase reaction in the mass spectrometer but the dissolution state of aluminum species can be shown by ESI-Q-MS. 相似文献
184.
Hiroyoshi Kawakami Kazue Hiraka Miho Tamai Aiko Horiuchi Akihiko Ogata Tomomi Hatsugai Aritomo Yamaguchi Kenichi Oyaizu Makoto Yuasa 《先进技术聚合物》2007,18(1):82-87
In this article the novel design of an anticancer drug delivery system is reported based on a pH‐sensitive liposome retaining the Fe‐porphyrin as a superoxide dismutase(SOD) mimic. The liposomes contained cationic/anionic lipid combinations and were composed of Fe‐porphyrin, L ‐α‐phosphatidylcholine (DMPC), dimethylditetradecylammonium bromide (DTDAB), sodispdum oleate (OANa), and Tween‐80. The size of the liposome was approximately 30 nm. The EC50 value (the effective concentration of compound required to produce a 50% lethal dose against cells) of the liposome was found to be significantly smaller than that of cisplatin as the control drug, suggesting that the liposome showed a high cytotoxicity toward the cancer cells. This is due to the fact that the pH‐sensitive liposome rapidly corresponds to the acidic environments of the endosomes and is unstable, and the Fe‐porphyrin is delivered into the cytosol. This result suggests that O may be useful as a target molecule to induce the selective death of cancer cells and that a pH‐sensitive liposome retaining Fe‐porphyrin as an SOD mimic is a new class of anticancer agent. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
185.
186.
Simple HPLC-UV determination of nucleosides and its application to the authentication of Cordyceps and its allies 总被引:1,自引:0,他引:1
A simple HPLC-UV method combined with a simple extraction procedure of nucleosides (adenosine, cordycepin, 2'-deoxyadenosine, guanosine and uridine) was developed and applied to the authentication of Cordyceps and its allies. The separation was performed on a C(18) column by isocratic elution with acetonitrile-water, and UV detection at 260 nm. The amounts of adenosine, cordycepin, 2'-deoxyadenosine, guanosine and uridine in Cordyceps were 0.28-14.15, 0.006-6.36, 0.01-0.14, 0.68-14.79 and 0.19-20.29 mg/g, respectively. Among the nucleosides studied, cordycepin was characteristically included in Cordyceps militaris (L.) Link. (CM), which is one of key Cordyceps allies, and might be a good marker for authenticating CM. The ratio of nucleosides to adenosine contents in Cordyceps seemed to be a useful marker for authentication and quality control of Cordyceps. 相似文献
187.
Ikeda Hirohito Ohata Tomonori Yukawa Miho Tsutsumi Hiroyuki Fujisawa Masao Aki Hatsumi 《Journal of inclusion phenomena and macrocyclic chemistry》2021,100(1-2):99-107
Journal of Inclusion Phenomena and Macrocyclic Chemistry - The inclusion of catechins with cyclodextrin (CD) is performed for the purpose of improving the water solubility and reducing the... 相似文献
188.
Miho Narita Hirokazu Urabe Fumie Sato 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2002,114(19):3823-3826
189.
Young Sook Yun Tomomi Nakano Haruhiko Fukaya Yukio Hitotsuyanagi Miho Nakamura Megumi Umetsu Nobuko Matsushita Katsunori Miyake Hiroyuki Fuchino Nobuo Kawahara Fuki Moriya Akihiro Ito Yuji Takahashi Hideshi Inoue 《Molecules (Basel, Switzerland)》2022,27(9)
Retusone A (1), a new sesquiterpene dimer consisting of two guaiane-type sesquiterpenoids, and oleodaphnal (2) were isolated from heartwood of Wikstroemia retusa (Thymelaeaceae). The planar structure of 1 was elucidated on the basis of HRESIMS and NMR spectroscopic data, and the relative stereochemistry was established by X-ray diffraction analysis. The absolute configuration of 1 was determined by electronic circular dichroism. Compound 1 suppressed luciferase reporter gene expression driven by the HBO1 (histone acetyltransferase binding to ORC1) gene promoter in human breast cancer MCF7 cells. Compound 1 also decreased the expression of endogenous HBO1 mRNA and protein, and inhibited proliferation of the cells. These results suggest that retusone A (1), which has a unique dimeric sesquiterpenoid structure with inhibitory activity against HBO1 expression, may contribute to the development of a novel therapeutic candidate for the treatment of breast cancer. 相似文献
190.
Mitsuhiko Morisue Miho Kawanishi Shinya Nakano 《Journal of polymer science. Part A, Polymer chemistry》2019,57(24):2457-2465
The first synthesis of the fully conjugated ethynylene‐linked polymer incorporating boron dipyrrine complex (BODIPY) and zinc porphyrin in the main chain was performed based on the exclusive Sonogashira polycondensation. Comprehensive experimental and theoretical investigations lead to an elaborate synthetic route to circumvent the possible side reactions of BODIPY in the presence of the palladium catalyst. Additionally, optimization of the synthetic conditions found that dichloromethane as the solvent suppresses the formation of the pseudo‐trans dimer of the copper acetylide and mitigates the undesired oxidative homocoupling reaction. Eventually, the exclusive Sonogashira polycondensation in dichloromethane provided the alternating BODIPY–porphyrin ethynylene‐conjugated polymer, which displayed absorption up to the near‐infrared wavelengths. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019 , 57, 2457–2465 相似文献