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271.
272.
Yunseok Heo Inhwan Lee Sunjin Moon Ji-Hye Yun Eun Yu Kim Sam-Yong Park Jae-Hyun Park Woo Taek Kim Weontae Lee 《Molecules (Basel, Switzerland)》2022,27(7)
Phospholipase is an enzyme that hydrolyzes various phospholipid substrates at specific ester bonds and plays important roles such as membrane remodeling, as digestive enzymes, and the regulation of cellular mechanism. Phospholipase proteins are divided into following the four major groups according to the ester bonds they cleave off: phospholipase A1 (PLA1), phospholipase A2 (PLA2), phospholipase C (PLC), and phospholipase D (PLD). Among the four phospholipase groups, PLA1 has been less studied than the other phospholipases. Here, we report the first molecular structures of plant PLA1s: AtDSEL and CaPLA1 derived from Arabidopsis thaliana and Capsicum annuum, respectively. AtDSEL and CaPLA1 are novel PLA1s in that they form homodimers since PLAs are generally in the form of a monomer. The dimerization domain at the C-terminal of the AtDSEL and CaPLA1 makes hydrophobic interactions between each monomer, respectively. The C-terminal domain is also present in PLA1s of other plants, but not in PLAs of mammals and fungi. An activity assay of AtDSEL toward various lipid substrates demonstrates that AtDSEL is specialized for the cleavage of sn-1 acyl chains. This report reveals a new domain that exists only in plant PLA1s and suggests that the domain is essential for homodimerization. 相似文献
273.
Ayoub Lafnoune Su-Yeon Lee Jin-Yeong Heo Khadija Daoudi Bouchra Darkaoui Salma Chakir Rachida Cadi Khadija Mounaji David Shum Haeng-Ran Seo Naoual Oukkache 《Molecules (Basel, Switzerland)》2022,27(7)
Hepatocellular carcinoma (HCC) is the most dominant primary liver cancer, which can be caused by chronic hepatitis virus infections and other environmental factors. Resection, liver transplantation, and local ablation are only a few of the highly effective and curative procedures presently accessible. However, other complementary treatments can reduce cancer treatment side effects. In this present work, we evaluated the activity of Moroccan scorpion venom Buthus occitanus and its fractions obtained by chromatography gel filtration against HCC cells using a 3D cell culture model. The venom was fractionated by gel filtration chromatography, each fraction and the crude venom was tested on normal hepatocytes (Fa2N-4 cells). Additionally, the fractions and the crude venom were tested on MCTSs (multicellular tumor spheroids), and this latter was generated by cultivate Huh7.5 cancer cell line with WI38 cells, LX2 cells, and human endothelial cells (HUVEC). Our results indicate that Buthus occitanus venom toxin has no cytotoxic effects on normal hepatocytes. Moreover, it is reported that F3 fraction could significantly inhibit the MCTS cells. Other Protein Separation Techniques (High-performance liquid chromatography) are needed in order to identify the most active molecule. 相似文献
274.
Ha Gayeon Heo Gyunyoung Seo Hana Choi Yujeong 《Journal of Radioanalytical and Nuclear Chemistry》2019,320(3):665-678
Journal of Radioanalytical and Nuclear Chemistry - According to the Incident and Trafficking Database of the International Atomic Energy Agency, incidents involving illegal transactions or... 相似文献
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277.
We designed a carboxamide-based fluorescent chemosensor HTPQ ((E)-2-(((8-hydroxy-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl)methylene)amino)thiophene-3-carboxamide) for detecting Al3+. HTPQ could probe Al3+ by fluorescence enhancement. Limit of detection for Al3+ toward HTPQ was 1.4 μM. Binding of HTPQ to Al3+ was determined to be a 1:1 ratio with the analysis of Job plot and ESI-mass. In addition, HTPQ was able to detect Al3+ using the test strip by fluorescent variation. The sensing process of Al3+ by HTPQ was presented by UV–vis titration, ESI–MS, Job plot, 1H NMR titration and DFT calculation.
相似文献278.
Park Young Jin Lee K. B. Lee J. M. Hwang S. H. Heo D. H. Kim B. J. 《Journal of Radioanalytical and Nuclear Chemistry》2021,328(2):493-505
Journal of Radioanalytical and Nuclear Chemistry - Generally, short-lived medical isotopes and/or their generators are produced in nuclear reactors and cyclotrons. During the last decade, the... 相似文献
279.
Gi-Seok Heo 《Journal of solid state chemistry》2009,182(10):2937-2940
We have fabricated ITO-ZnO composition spread films to investigate the effects of substrate temperature on their electrical and optical properties by using combinatorial RF magnetron sputtering. It turned out by X-ray measurement that the film with zinc contents above 16.0 at% [Zn/(In+Zn+Sn)] showed amorphous phase regardless of substrate temperature. The amorphous ITO-ZnO film had lower resistivity than polycrystalline films. When the films were deposited at 250 °C, the minimum resistivity of 3.0×10−4 Ω cm was obtained with the zinc contents of 16.0 at%. The indium content could be reduced as high as ~30 at% compared to that of ITO for the films having similar resistivity (~10−4 Ω cm). However, a drastic increase of resistivity was observed for the ITO-ZnO films deposited at 350 °C, having zinc contents below 15.2 at%. 相似文献
280.
PbSe quantum dots (QDs) were synthesized in borosilicate glass and their optical properties were investigated. The typical quantum confinement effects were clearly observed from the absorption when the average radii of the QDs changed from 1.7 to 3.1 nm. Photoluminescence from PbSe QDs was achieved in 1.1–2.2 μm wavelength region that covers the entire fiber-optic telecommunication window. Borosilicate glasses containing controlled size of PbSe QDs provide potentials for the fiber-optic amplifiers. 相似文献