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31.
Hironao Nakayama Masako Nakahara Erina Matsugi Midori Soda Tomoka Hattori Koki Hara Ayuki Usami Chiaki Kusumoto Shigeki Higashiyama Kiyoyuki Kitaichi 《Molecules (Basel, Switzerland)》2021,26(1)
Ferulic Acid (FA) is a highly abundant phenolic phytochemical which is present in plant tissues. FA has biological effects on physiological and pathological processes due to its anti-apoptotic and anti-oxidative properties, however, the detailed mechanism(s) of function is poorly understood. We have identified FA as a molecule that inhibits apoptosis induced by hydrogen peroxide (H2O2) or actinomycin D (ActD) in rat pheochromocytoma, PC12 cell. We also found that FA reduces H2O2-induced reactive oxygen species (ROS) production in PC12 cell, thereby acting as an anti-oxidant. Then, we analyzed FA-mediated signaling responses in rat pheochromocytoma, PC12 cells using antibody arrays for phosphokinase and apoptosis related proteins. This FA signaling pathway in PC12 cells includes inactivation of pro-apoptotic proteins, SMAC/Diablo and Bad. In addition, FA attenuates the cell injury by H2O2 through the inhibition of phosphorylation of the extracellular signal-regulated kinase (ERK). Importantly, we find that FA restores expression levels of brain-derived neurotrophic factor (BDNF), a key neuroprotective effector, in H2O2-treated PC12 cells. As a possible mechanism, FA increases BDNF by regulating microRNA-10b expression following H2O2 stimulation. Taken together, FA has broad biological effects as a neuroprotective modulator to regulate the expression of phosphokinases, apoptosis-related proteins and microRNAs against oxidative stress in PC12 cells. 相似文献
32.
Yoshinori SaitoYuriko Takashima Aya KamadaYurika Suzuki Midori SuenagaYasuko Okamoto Yoichi MatsunagaRyo Hanai Takayuki KawaharaXun Gong Motoo Tori Chiaki Kuroda 《Tetrahedron》2012,68(48):10011-10029
Root chemicals and DNA sequences were analyzed for Ligularia virgaurea collected in the northern Sichuan Province and adjacent areas of China. Thirty-eight samples were found to contain five chemotypes, two known and three new ones. From samples of the new chemotypes, 13 new compounds were isolated, including 3 sesquiterpene dimers and some rearranged eremophilanes. The DNA sequences suggested that the chemotype differentiation had a genetic origin. 相似文献
33.
Midori Nishide Yutaka Yoshikawa Eriko U Yoshikawa Kinuyo Matsumoto Hiromu Sakurai Naemi M Kajiwara 《Chemical & pharmaceutical bulletin》2008,56(8):1181-1183
We prepared 4 new Zn(II) complexes with Zn(O4), Zn(N(2)O(2)), and Zn(S2O2) coordination modes and evaluated their insulinomimetic activities in an in vitro study. The insulinomimetic activities of bis(pyrrole-2-carboxylato)zinc (Zn(pc)2), bis(alpha-furonic acidato)zinc (Zn(fa)2), bis(thiophene-2-carboxylato)zinc (Zn(tc)2), and bis(thiophene-2-acetato)zinc (Zn(ta)2) complexes were found to be higher than that of zinc sulfate (ZnSO4). Zn(ta)2 showed the highest insulinomimetic activity among the Zn(II) complexes because of its high lipophilicity. 相似文献
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36.
Midori Yasuda Tamiyoshi Sonda Tomoko Hiraoka Aki Horita Masaaki Tabata 《Analytical sciences》2003,19(12):1637-1641
The retention behavior and mechanism of methyl, ethyl, propyl, isopropyl, buthyl and isobuthyl benzoates have been studied at different eluent compositions of aqueous mixtures with water-soluble organic solvents (methanol, ethanol, 1-propanol, 2-propanol, acetonitrile (AN), 1,4-dioxane and tetrahydrofuran (THF)) in RPLC. The retention of the solutes is discussed based on the solvent composition, solvent polarity (ETN value), preferential solvation, hydrogen bonding and solvent clusters of the eluents. The smaller ETN values and the larger preferential solvation of the mixed solvent eluted the solutes faster. The IR spectra of HDO suggested that the solvents, except for methanol and ethanol, break the hydrogen bonding between water molecules, resulting in fast elution of the solutes. Based upon the results, we chose an optimum solvent composition for the separation of benzoates and applied it to the determination of the benzoates in clove. 相似文献
37.
Yukio Fujimori Takashi Kaneko Takahiko Kaku Naoki Yoshioka Hiroyuki Nishide Eishun Tsuchida 《先进技术聚合物》1992,3(8):437-441
The polymerization behavior and photoinitiation process in the visible light-cured dental composite resins were studied using ESR and IR spectroscopies. The concentration of methacryl propagating radical corresponded to the transmittance of irradiated light. While the radical was stable and long-lived in the cured resin, its concentration quickly decreased in the oral cavity due to the ventilation of atmospheric oxygen accompanied by respiration. Camphorquinone radical in the presence of tertiary amine easily initiated the radical polymerization. A decrease in monomer consumption was explained by the inhibition effect of oxygen in the photoinitiation process. Post-curing by the residual radical proceeded effectively in the deeper part of the resin. 相似文献
38.
Kenichi Oyaizu Kimihisa Yamamoto Toshio Asada Hiroyuki Nishide Eishun Tsuchida 《先进技术聚合物》1995,6(4):254-257
The effect of substituents on the electropolymerization of benzene derivatives and the redox properrties of the corresponding polymers were determined using Brown's substituent constants (σ+). Electron-donating groups lower the oxidation potential by which increase in the current efficiency was observed. However, stabilization of the produced cation radicals by the electron-donating groups resulted in a decrease in the polymerization efficiency. The appropriate values of σ+ for the efficient polymerization ranged near ?1.5. 相似文献
39.
Magnetic ordering of YFeMnO4 has been studied with Mössbauer spectroscopy in the temperature range between 4.2 K and 300 K on the conditions of gamma rays parallel to and perpendicular to thec-axis. It is revealed that the spin system orders like a Heisenberg spin system in a triangular antiferromagnet with an anisotropic axis parallel to thec-axis. 相似文献
40.
Lima Héstia Raíssa Batista Reis Nascimento Débora Siqueira Sussuchi Eliana Midori d’Errico Francesco de Souza Susana Oliveira 《Journal of Sol-Gel Science and Technology》2017,81(3):797-805
Journal of Sol-Gel Science and Technology - Magnesium-tetraborates and lithium-tetraborates are excellent detectors for ionizing radiation. However, manufacturing these crystalline structures is... 相似文献