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21.
Hironao Nakayama Masako Nakahara Erina Matsugi Midori Soda Tomoka Hattori Koki Hara Ayuki Usami Chiaki Kusumoto Shigeki Higashiyama Kiyoyuki Kitaichi 《Molecules (Basel, Switzerland)》2021,26(1)
Ferulic Acid (FA) is a highly abundant phenolic phytochemical which is present in plant tissues. FA has biological effects on physiological and pathological processes due to its anti-apoptotic and anti-oxidative properties, however, the detailed mechanism(s) of function is poorly understood. We have identified FA as a molecule that inhibits apoptosis induced by hydrogen peroxide (H2O2) or actinomycin D (ActD) in rat pheochromocytoma, PC12 cell. We also found that FA reduces H2O2-induced reactive oxygen species (ROS) production in PC12 cell, thereby acting as an anti-oxidant. Then, we analyzed FA-mediated signaling responses in rat pheochromocytoma, PC12 cells using antibody arrays for phosphokinase and apoptosis related proteins. This FA signaling pathway in PC12 cells includes inactivation of pro-apoptotic proteins, SMAC/Diablo and Bad. In addition, FA attenuates the cell injury by H2O2 through the inhibition of phosphorylation of the extracellular signal-regulated kinase (ERK). Importantly, we find that FA restores expression levels of brain-derived neurotrophic factor (BDNF), a key neuroprotective effector, in H2O2-treated PC12 cells. As a possible mechanism, FA increases BDNF by regulating microRNA-10b expression following H2O2 stimulation. Taken together, FA has broad biological effects as a neuroprotective modulator to regulate the expression of phosphokinases, apoptosis-related proteins and microRNAs against oxidative stress in PC12 cells. 相似文献
22.
Yoshinori SaitoYuriko Takashima Aya KamadaYurika Suzuki Midori SuenagaYasuko Okamoto Yoichi MatsunagaRyo Hanai Takayuki KawaharaXun Gong Motoo Tori Chiaki Kuroda 《Tetrahedron》2012,68(48):10011-10029
Root chemicals and DNA sequences were analyzed for Ligularia virgaurea collected in the northern Sichuan Province and adjacent areas of China. Thirty-eight samples were found to contain five chemotypes, two known and three new ones. From samples of the new chemotypes, 13 new compounds were isolated, including 3 sesquiterpene dimers and some rearranged eremophilanes. The DNA sequences suggested that the chemotype differentiation had a genetic origin. 相似文献
23.
H Kuwabara 《The Journal of the Acoustical Society of America》1985,77(2):686-694
A method is proposed to reduce the ambiguity of vowels in connected speech by normalizing the coarticulation effects. The method is applied to vowels in phonetic environments where great ambiguity would be likely to occur, taking as their features the first and second formant trajectories. The separability between vowel clusters is found to be greatly improved for the vowel samples. In addition, distribution of the vowels on a feature plane characterized by this method seems to reflect their perceptual nature when presented to listeners without isolation from their phonetic environments. The results suggest that the method proposed here is useful for automatic speech recognition and help infer some possible mechanisms underlying dynamic aspects of human speech recognition. 相似文献
24.
New fabrication method for anisotropic gratings formed in photocrosslinkable polymer liquid crystals
H.?OnoEmail author A.?Emoto N.?Kawatsuki E.?Uchida M.?Kuwabara 《Applied Physics A: Materials Science & Processing》2004,79(7):1725-1727
We present a new fabrication method, called two-step ultraviolet exposure, to prepare anisotropic gratings in photocrosslinkable polymer liquid crystal films. Using the controllability of the reorientation direction of mesogenic molecules, anisotropic phase gratings, in which the mesogenic molecules were periodically modulated in orthogonal directions, were prepared by the use of one grating photomask. The resultant gratings diffract the light and convert the polarization states at the same time, and have applications as diffraction optical devices. PACS 42.65.Hw; 42.70.Df; 42.70.Nq; 78.20.-e; 78.40.Me 相似文献
25.
Reliability of mean transit time obtained using perfusion-weighted MR imaging; comparison with positron emission tomography 总被引:2,自引:0,他引:2
Mihara F Kuwabara Y Tanaka A Yoshiura T Sasaki M Yoshida T Masuda K Matsushima T 《Magnetic resonance imaging》2003,21(1):33-39
The purpose of this project was to assess the reliability of the cerebral mean transit time (MTT) obtained using perfusion-weighted MR imaging by comparing it with the MTT obtained when performing positron emission tomography (PET). Ten patients with chronic occlusive cerebrovascular disease were investigated. They had either unilateral internal carotid artery occlusion or middle cerebral artery occlusion. The regions-of-interest were placed in non-infarcted areas within the territory of the middle cerebral artery on the affected side. Control regions-of-interest were placed in mirrored regions of the contralateral side. Linear regression analyses were performed using the parameters of the MTT obtained with perfusion-weighted MR imaging and the MTT, cerebral blood flow, vascular reactivity, and oxygen extraction fraction obtained with PET. The respective MTTs of the affected and non-affected sides obtained with perfusion-weighted MR imaging versus those with PET were 7.3 +/- 2.2 s and 6.0 +/- 1.2 s versus 8.2 +/- 3.0 s and 6.4 +/- 1.7 s. The MTT obtained using perfusion-weighted MR imaging and PET demonstrated statistically significant correlation (r = 0.87, p < 0.0001). The MTT obtained with perfusion-weighted MR imaging correlated statistically with cerebral blood flow (r = -0.74, p < 0.001), vascular reactivity (r = -0.73, p < 0.001) and oxygen extraction fraction (r = 0.61, p < 0.01). Similarly, the MTT obtained using PET statistically correlated with cerebral blood flow (r = -0.78, p < 0.0001), vascular reactivity (r = -0.51, p < 0.05) and oxygen extraction fraction (r = 0.68, p < 0.01). The reliability of the MTT obtained using perfusion-weighted MR imaging appears to be approximately equal to that obtained with positron emission tomography. 相似文献
26.
S. Hirano S. Shimada M. Kuwabara 《Applied Physics A: Materials Science & Processing》2005,80(4):783-786
We demonstrate a method for fabricating a two-dimensional hexagonal array of nanoscale barium titanate ceramic pillars. A precursor array was prepared by introducing a sol solution into an electron-beam resist mold with air holes and subsequently dry etching the unnecessary gel layer formed on the mold. A ceramic array, consisting of barium titanate ceramic pillars with a radius of 85 nm, a lattice constant of 450 nm, and a height of 500 nm, was fabricated by sintering the precursor array at 1073 K. The reflection spectra for the ceramic array in the visible range revealed the underlying photonic band gaps, which were in good agreement with results calculated using a plane-wave method. PACS 77.84.-s; 42.70.-a; 42.70.Qs 相似文献
27.
Midori Nishide Yutaka Yoshikawa Eriko U Yoshikawa Kinuyo Matsumoto Hiromu Sakurai Naemi M Kajiwara 《Chemical & pharmaceutical bulletin》2008,56(8):1181-1183
We prepared 4 new Zn(II) complexes with Zn(O4), Zn(N(2)O(2)), and Zn(S2O2) coordination modes and evaluated their insulinomimetic activities in an in vitro study. The insulinomimetic activities of bis(pyrrole-2-carboxylato)zinc (Zn(pc)2), bis(alpha-furonic acidato)zinc (Zn(fa)2), bis(thiophene-2-carboxylato)zinc (Zn(tc)2), and bis(thiophene-2-acetato)zinc (Zn(ta)2) complexes were found to be higher than that of zinc sulfate (ZnSO4). Zn(ta)2 showed the highest insulinomimetic activity among the Zn(II) complexes because of its high lipophilicity. 相似文献
28.
29.
Midori Yasuda Tamiyoshi Sonda Tomoko Hiraoka Aki Horita Masaaki Tabata 《Analytical sciences》2003,19(12):1637-1641
The retention behavior and mechanism of methyl, ethyl, propyl, isopropyl, buthyl and isobuthyl benzoates have been studied at different eluent compositions of aqueous mixtures with water-soluble organic solvents (methanol, ethanol, 1-propanol, 2-propanol, acetonitrile (AN), 1,4-dioxane and tetrahydrofuran (THF)) in RPLC. The retention of the solutes is discussed based on the solvent composition, solvent polarity (ETN value), preferential solvation, hydrogen bonding and solvent clusters of the eluents. The smaller ETN values and the larger preferential solvation of the mixed solvent eluted the solutes faster. The IR spectra of HDO suggested that the solvents, except for methanol and ethanol, break the hydrogen bonding between water molecules, resulting in fast elution of the solutes. Based upon the results, we chose an optimum solvent composition for the separation of benzoates and applied it to the determination of the benzoates in clove. 相似文献
30.
Magnetic ordering of YFeMnO4 has been studied with Mössbauer spectroscopy in the temperature range between 4.2 K and 300 K on the conditions of gamma rays parallel to and perpendicular to thec-axis. It is revealed that the spin system orders like a Heisenberg spin system in a triangular antiferromagnet with an anisotropic axis parallel to thec-axis. 相似文献