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101.
Michelle G. Zeles-Hahn Yvonne K. Lentz Thomas J. Anchordoquy Corinne S. Lengsfeld 《Journal of Electrostatics》2011,69(1):67-77
Aerosolization techniques for delivery of gene therapies to the lungs decrease activity of these treatments. The low transfection is attributed to loss in molecular integrity. Electrosprays can aerosolize DNA without structural loss. Electrospray affects on human pulmonary cells are unknown. This study is to assess toxicity, inflammatory response, and transfection of DNA mixtures delivered via electrospray to human pulmonary cells. EpiAirway? cells are cultured on air–liquid interfaces and simulate in vivo. All conditions examined (except PEI/DNA 10:1) showed no toxic or inflammation response. Transfection was not observed. In vitro results indicate that electrosprays have potential for administering DNA therapeutics pulmonarily. 相似文献
102.
D. Bradley G. Williams Sandile B. Simelane Michelle Lawton Henok H. Kinfe 《Tetrahedron》2010,66(25):4573-100
A simple and efficient method for the conversion of alcohols and phenols into their corresponding THP and THF ethers at room temperature has been developed using 1 mol % aluminium triflate as catalyst. The deprotection reaction in the presence of methanol using Al(OTf)3 was equally successful and could be performed at ambient temperature in high yields. 相似文献
103.
Nathan C. Twaddle Mona I. Churchwell Michelle Vanlandingham Daniel R. Doerge 《Rapid communications in mass spectrometry : RCM》2010,24(20):3011-3020
Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products, epoxy resin‐based food can liners, and paper products. The presence of BPA in urine of >90% of Americans aged 6–60 suggests ubiquitous and frequent exposure and is problematic because of the potential for endocrine disruption. The ubiquity of environmental BPA in common laboratory supplies used for sample collection, storage, and analysis greatly increases the likelihood of false positive determinations, particularly at trace levels. The current study validated using liquid chromatography/tandem mass spectrometry (LC/MS/MS) in conjunction with deuterated BPA as the dosing material to circumvent contamination for high sensitivity quantifications in rat serum, tissues, urine, and feces. The methods described provided measurements of both estrogen receptor‐active aglycone and metabolically deactivated conjugated forms of BPA, a distinction that is critical to assessing toxicological potential. The adequacy of the described methodology was substantiated by its utility in analyzing samples from rats treated orally with a 100 µg/kg body weight dose of d6‐BPA. These results emphasize the challenges inherent in measuring BPA in biological samples and how employing stable isotope labeled dosing can facilitate pharmacokinetic studies needed to understand BPA metabolism and disposition. Such studies conducted in experimental animal models, in conjunction with properly validated human biomonitoring data, will be the basis for PBPK modeling of BPA in environmentally exposed humans. Published in 2010 by John Wiley & Sons, Ltd. 相似文献
104.
Leesa M. Smith Michelle L. Coote 《Journal of polymer science. Part A, Polymer chemistry》2013,51(16):3351-3358
The effect of temperature and solvent on polymer tacticity in free‐radical polymerization of styrene and methyl methacrylate was studied by 13C and 1H NMR, respectively. Polystyrene shows a mild syndiotactic tendency (Pm = 0.36 ± 0.02) that is independent of temperature over a wide range (?10 to 120 °C), while poly(methyl methacrylate) shows a stronger syndiotactic tendency (Pm = 0.17 ± 0.01 at 30 °C) that decreases as temperature is increased (Pm = 0.22 ± 0.02 at 80 °C). None of the polymerization solvents studied (bulk, THF, DMF, DMSO, acetonitrile, and acetone) had a significant effect on polymer tacticity in either system. The triad fractions of both polymers showed deviations from the Bernoulli model, implying that the antepenultimate unit affects the propagation reaction. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013 , 51, 3351–3358 相似文献
105.
We establish extension theorems for functions in spaces which arise naturally in studying interpolation by radial basic functions. These spaces are akin in some way to the non-integer-valued Sobolev spaces, although they are considerably more general. Such extensions allow us to establish local error estimates in a way which we make precise in the introductory section of our paper. There are many other applications of these fundamental results, including improved Lp error estimates for interpolation by shifts of a single basic function, but these applications have been left to a later paper. 相似文献
106.
The perception of auditory roughness presumably results from imperfect spectral or temporal resolution. Sensorineural hearing loss, by affecting spectral resolution, may therefore alter roughness perception. In this study, normal-hearing and hearing-impaired listeners estimated the roughness of amplitude-modulated tones varying in carrier frequency, modulation rate, and modulation depth. Their judgments were expected to reflect effects of impaired spectral resolution. Instead, their judgments were similar, in most respects, to those of normally-hearing listeners, except at very slow modulation rates. Results suggest that mild-to-moderate sensorineural hearing loss increases the roughness of slowly fluctuating signals. 相似文献
107.
In this paper, a study is made of the damping influence of the wall on turbulent fluid flow. By considering the oscillation of the whole of the boundary, van Driest's original hypothesis has been extended to obtain the wall damping factor in flow in a duct of constant cross section. The damping factor is used in conjunction with mixing length expressions to obtain the velocity field. Particular examples considered are plane parallel flow and axisymmetric flow in a pipe and in an annulus.
Nomenclature A, A*(=Au/v) Parameter defined in text - b, b*(=bu/v) semi-width of parallel plate channel - c(= 1/A) parameter defined in text - E[, /2] complete elliptic integral of the second kind - d damping factor - F, G, H functions - l, l*(=/v) mixing length - MO, O functions - r, r*(=ru/v) radius - A real part of function - R, S, T, U functions - u, u*(=u/u) velocity in flow direction Z - friction velocity - x, y, z co-ordinates (z in flow direction) - y*(=yu/v) non-dimensional wall distance - fluid density - , eff kinematic viscosity, effective kinematic viscosity - phase angle, or polar coordinate angle - shear stress - (=r/rW) radius ratio - angular velocity Suffixes w wall value - far from a wall 相似文献
Ein Modell für die Mischungslänge von turbulenten Strömungen in Rohren mit konstantem Querschnitt
Zusammenfassung In dieser Arbeit wurde der dämpfende Wandeinfluß in turbulenten Strömungen untersucht. Unter Berücksichtigung der Schwingungen in der gesamten Grenzschicht wurde die ursprüngliche Theorie von van Driest erweitert und ein Dämpfungsfaktor an der Wand in Rohrströmungen mit konstantem Querschnitt ermittelt. Dieser Dämpfungsfaktor diente in Verbindung mit Ausdrücken für die Mischungslänge zur Bestimmung des Geschwindigkeitsfeldes. Ausgewählte Beispiele waren die ebene Parallelströmung sowie die Zylinderströmung in einem Rohr und einem Ringspalt.
Nomenclature A, A*(=Au/v) Parameter defined in text - b, b*(=bu/v) semi-width of parallel plate channel - c(= 1/A) parameter defined in text - E[, /2] complete elliptic integral of the second kind - d damping factor - F, G, H functions - l, l*(=/v) mixing length - MO, O functions - r, r*(=ru/v) radius - A real part of function - R, S, T, U functions - u, u*(=u/u) velocity in flow direction Z - friction velocity - x, y, z co-ordinates (z in flow direction) - y*(=yu/v) non-dimensional wall distance - fluid density - , eff kinematic viscosity, effective kinematic viscosity - phase angle, or polar coordinate angle - shear stress - (=r/rW) radius ratio - angular velocity Suffixes w wall value - far from a wall 相似文献
108.
109.
Cody Ross Pitts Michelle Sheanne Bloom Desta Doro Bume Qinze Arthur Zhang Thomas Lectka 《Chemical science》2015,6(9):5225-5229
Expanding the repertoire of controlled radical fluorination techniques, we present a photosensitized unstrained C–C bond activation/directed monofluorination method using Selectfluor and 9-fluorenone. The reaction is amenable to the opening of multiple 1-acetal-2-aryl substituted rings to yield ω-fluoro carboxylic acids, esters, alcohols, and ketones with relative ease. Initial mechanistic insight suggests radical ion intermediates. 相似文献
110.
Robin B. Bedford Steven J. Durrant Michelle Montgomery 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2015,127(30):8911-8914
The regiodivergent palladium‐catalyzed C H arylation of pyrazolo[1,5‐a]pyrimidine has been achieved, wherein the switch in regioselectivity between positions C3 and C7 is under complete catalyst control. A phosphine‐containing palladium catalyst promotes the direct arylation at the most acidic position (C7), whereas a phosphine‐free catalyst targets the most electron‐rich position (C3). 相似文献