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51.
Claudio Bianchini Pierluigi Barbaro Michela Macchi Andrea Meli Francesco Vizza 《Helvetica chimica acta》2001,84(10):2895-2923
As part of our modelling studies of the hydrodenitrogenation of N‐heterocycles contained in raw oil materials, we investigated the selective hydrogenation of quinoline to 1,2,3,4‐tetrahydroquinoline by rhodium catalysts modified with the tripodal polyphosphane ligand MeC(CH2PPh2)3. Experiments in standard autoclaves and in high‐pressure sapphire NMR tubes, kinetic and isotope labelling studies, and independent reactions with isolated compounds have contributed to the elucidation of the catalytic mechanism as well as identification of the electronic requisites of the metal catalyst for selective and efficient hydrogenation. 相似文献
52.
Sara Salucci Michela Battistelli Sabrina Burattini Cesare Squillace Barbara Canonico Pietro Gobbi Stefano Papa Elisabetta Falcieri 《Micron (Oxford, England : 1993)》2010,41(8):966-973
Apoptosis is a form of cell death crucial for normal development and tissue homeostasis. Its typical features include chromatin changes, nuclear breakdown, plasma membrane blebbing and splitting of cellular content into apoptotic bodies, that progressively undergo phagocytosis.Apoptosis is considered essential for skeletal muscle development, where defective cells are deleted during differentiation. In addition, it plays a relevant role in several muscle myopathies, as well as in denervation and disuse.The aim of this study was to evaluate muscle cell sensitivity to different apoptotic triggers, acting through different mechanisms of action. Chemical agents, active against distinct intracellular targets, such as mitochondrial respiratory chain and DNA, have been chosen to better highlight cell death mechanisms. To induce apoptosis, C2C12 myoblasts have been exposed to H2O2, staurosporine, cisplatin and etoposide, at different doses and incubation times, and they have been analysed by flow cytometry, scanning and transmission electron microscopy.Flow cytometry analysis revealed a certain subdiploid peak after all treatments. The best apoptotic effect was observable, as confirmed at reverted microscope, at minimum doses and after the major exposure time.At ultrastructural level programmed cell death has been observed. Characteristic chromatin condensation and margination, as well as apoptotic bodies, frequently appeared, even if in the presence of secondary necrosis; surface blebs were also observed during scanning microscopic observation.In particular, exposure to H2O2 or staurosporine showed the largest number of myoblasts in late apoptotic stages and in secondary necrosis. Cisplatin treatments revealed few early apoptotic cells. The analysis of etoposide-induced apoptosis was in agreement with data obtained from flow cytometry, indicating a significant increase of apoptotic cell number.These results suggest that all conditions are able to induce apoptosis in C2C12 myoblasts, which occurs, considering trigger mechanisms of action, mostly following the mitochondrial pathway, if not excluding that due to DNA damage. Therefore, mitochondria permeability alteration is an important step in skeletal muscle programmed cell death. This last conclusion seems to have a significant relevance in understanding the mechanisms involved in muscle disorders, denervation and chronic muscle disuse, conditions frequently characterized by a decline in mitochondrial content and by an increase of mitochondrial apoptosis susceptibility. 相似文献
53.
Michela Svaluto Moreolo Flavia Silvestri Mariateresa Armellino Kurt Hingerl Gabriella Cincotti 《Photonics and Nanostructures》2006,4(3):155-160
We present a highly integrated add/drop multiplexer, where the contra-directional coupling is realized by phase matching two photonic crystal waveguides. The device band structure, the corresponding transmission and drop spectra, and the coupling length are carefully analysed. Different device configurations are discussed and by tailoring the coupling factor, we optimize the frequency response of the filter, obtaining a -sized channel selector, characterized by a very high drop efficiency. 相似文献
54.
Michela Gasperini Chiara Remondini Alessandro Caselli Sergio Cenini 《Journal of organometallic chemistry》2005,690(20):4517-4529
The application of the palladium-phenanthroline catalytic system to the carbonylation of nitrobenzene in the presence of aniline to afford diphenylurea has been investigated. The reaction is best performed with equimolar amounts of the two reagents. Use of higher concentrations of either aniline or nitrobenzene or an increase in temperature in the range 120-170 °C leads to the formation of higher amounts of azo- and azoxybenzene. The latter were found to contain exclusively the aryl moiety deriving from nitrobenzene, with no inclusion of that derived from aniline. The addition of a small amount of diphenylphosphinic acid doubles the conversion and improves the selectivity in diphenylurea, but the effect is attenuated for larger amounts of acid. Small amounts of chloride, of the order of 10-30 mol% with respect to palladium, improve both rate and selectivity, but only inhibiting effects are detected when chloride is added to the reaction mixture for the carbonylation of 2,4-dinitrotoluene to dimethyl 2,4-toluenedicarbamate. The data obtained and that previously reported in the literature has been analyzed in the context of a unifying mechanism and an explanation for some apparent contradictions has been given. 相似文献
55.
Galarneau A Cangiotti M di Renzo F Fajula F Ottaviani MF 《The journal of physical chemistry. B》2006,110(9):4058-4065
The computer aided analysis of the EPR spectra of radical surfactant probes inserted in cetyltrimethylammonium bromide micelles provided information on the kinetics of formation of micelle templated silico-aluminas (MTSA) at 343 K, obtained by means of silica and alumina alkaline solutions at different Si/Al ratios (from infinity to 4). Mainly two spectral components were analyzed and relatively quantified in the EPR spectra: (1) the micellar component, due to probes inserted in the surfactant aggregates, whose mobility decreases over the synthesis time, thus reporting on the progressive modification of the micelle structure and the solid condensation; (2) the interacting component, mainly arising from the electrostatic interactions between the surfactant heads and the charged surface sites. This last component increases its relative intensity over the synthesis time, informing about condensation and structuration of the silico-alumina at the micelle surface. X-ray diffraction (XRD), nitrogen sorption isotherms at 77 K, thermogravimetric analysis, TEM and chemical analysis were performed to characterize both as-synthesized and calcined MTSA materials. Nitrogen sorption isotherms allowed us to evaluate the pore diameter, the specific surface area and the pore volume. At Si/Al<15 a decrease in pore volume and specific surface area was interpreted as due to the contemporaneous presence of a hexagonal MTSA and an amorphous material, which was ascertained by means of XRD as the only present at Si/Al=4. The amorphous structure at Si/Al<15 used Na+ as contraions, whereas the surfactants are no more needed to neutralize the negatively charged groups at the solid surface. The hypothesis of a "break" at Si/Al=15 was supported by EPR: the interactions between the surfactant probe heads and the negatively charged surface groups are drastically reduced at Si/Al<15. On the contrary, at Si/Al>15, increasing amounts of alumina slow the kinetics of the synthesis but enhance electrostatic interactions between the surfactant heads and the negatively charged surface groups. Dilution of the synthesis mixture decreased the extent of the interactions, due to partial protonation of the silanol groups, and slowed the synthesis process. 相似文献
56.
Bruno Benedetti Michela Di Marca Matteo Varbaro 《Journal of Pure and Applied Algebra》2018,222(9):2596-2608
We show that in arithmetically-Gorenstein line arrangements with only planar singularities, each line intersects the same number of other lines. This number has an algebraic interpretation: it is the Castelnuovo–Mumford regularity of the coordinate ring of the arrangement.We also prove that every -dimensional simplicial complex whose 0-th and 1-st homologies are trivial is the nerve complex of a suitable d-dimensional standard graded algebra of depth ≥3. This provides the converse of a recent result by Katzman, Lyubeznik and Zhang. 相似文献
57.
In our research work, we have looked at the way in which artefacts become, for teachers as well as for students, instruments of their mathematical activity. The issues related to the use of tools and technologies in mathematical education are now widely considered. A look to history highlights the different ways in which the same questions have been studied at different times and in different places. This suggests that the contribution of artefacts to mathematics learning should be considered in terms of various contexts. Our “visits” to these contexts will be guided by the coordination of two main theoretical frameworks, the instrumental approach and the semiotic mediation approach from the perspective of mathematics laboratory. This journey through history and schooling represents a good occasion to address some questions: Are there “good” contexts in which to develop mathematical instruments? Are there “good” teaching practices which assist students’ instrumental geneses and construct mathematical meanings? How is it possible to promote such teaching practices? Some study cases are discussed. 相似文献
58.
59.
A classical result of McDuff [14] asserts that a simply connected complete Kähler manifold $(M,g,\omega )$ with non positive sectional curvature admits global symplectic coordinates through a symplectomorphism $\Psi \ : M \rightarrow \mathbb{R }^{2n}$ (where $n$ is the complex dimension of $M$ ), satisfying the following property (proved by E. Ciriza in [4]): the image $\Psi (T)$ of any complex totally geodesic submanifold $T\subset M$ through the point $p$ such that $\Psi (p)=0$ , is a complex linear subspace of $\mathbb C ^n\simeq \mathbb{R }^{2n}$ . The aim of this paper is to exhibit, for all positive integers $n$ , examples of $n$ -dimensional complete Kähler manifolds with non-negative sectional curvature globally symplectomorphic to $\mathbb{R }^{2n}$ through a symplectomorphism satisfying Ciriza’s property. 相似文献
60.