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21.
Maria Grazia Signorello Federica Rapetti Elda Meta Adama Sidib Olga Bruno Chiara Brullo 《Molecules (Basel, Switzerland)》2021,26(19)
(1) Background: different previously synthesized pyrazoles and imidazo-pyrazoles showed interesting anti-angiogenic action, being able to interfere with ERK1/2, AKT and p38MAPK phosphorylation in different manners and with different potency; (2) Methods: here, a new small compound library, endowed with the same differently decorated chemical scaffolds, has been synthetized to obtain new agents able to inhibit different pathways involved in inflammation, cancer and human platelet aggregation. (3) Results: most of the new synthesized derivatives resulted able to block ROS production, platelet aggregation and p38MAPK phosphorylation both in platelets and Human Umbilical Vein Endothelial cells (HUVEC). This paves the way for the development of new agents with anti-angiogenic activity. 相似文献
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Ivona Elez Garofuli Valentina Malin Maja Repaji Zoran Zori Sandra Pedisi Meta Sternia Sonja Smole Moina Verica Dragovi-Uzelac 《Molecules (Basel, Switzerland)》2021,26(20)
Nettle is a widely known plant whose high biological activity and beneficial medicinal effects are attributed to various bioactive compounds, among which polyphenols play an important role. In order to isolate polyphenols and preserve their properties, advanced extraction techniques have been applied to overcome the drawbacks of conventional ones. Therefore, microwave-assisted extraction (MAE) has been optimized for the isolation of nettle leaves polyphenols and it was compared to pressurized liquid extraction (PLE) and conventional heat-reflux extraction (CE). The obtained extracts were analyzed for their individual phenolic profile by UPLC MS2 and for their antioxidant capacity by ORAC assay. MAE proved to be the more specific technique for the isolation of individual phenolic compounds, while PLE produced extracts with higher amount of total phenols and higher antioxidant capacity. Both techniques were more effective compared to CE. PLE nettle extract showed antimicrobial activity against bacteria, especially against Gram-negative Pseudomonas fragi ATCC 4973 and Campylobacter jejuni NCTC 11168 strains. This suggests that PLE is suitable for obtaining a nettle extract with antioxidant and antimicrobial potential, which as such has great potential for use as a value-added ingredient in the food and pharmaceutical industry. 相似文献
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Stefanie Meyer Neil J. Martinez Meta Eberhard Schweda Prof. Dr. Oliver Eibl 《无机化学与普通化学杂志》2009,635(15):2470-2473
A powder of the composition 40 mol‐% Er2O3 and 60 mol‐% ZrO2 has been prepared. The anion deficient fluorite related compound Zr3Er4O12 [R\bar{3} : a = 971.79(7) pm and c = 907.976(0) pm] was produced. This precursor was treated with gaseous ammonia at temperatures between 25 and 1200 °C. The reaction was followed in situ by X‐ray diffraction in a high temperature reaction chamber under a constant flow of ammonia. The nitridation of Zr3Er4O12 led to a nitride oxide of the solid‐solution‐type with an apparent composition Zr0.43Er0.57O1.07N0.43 The compound crystallizes isostructural to bixbyite due to vacancy ordering [Ia\bar{3} : a = 1036.37(4) pm]. The reoxidation of the nitride oxide was monitored in DTA/TG experiments exhibiting an almost complete reoxidation to the starting composition except for some inclusions of dinitrogen. 相似文献
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Richard A. Russell Geoffrey J. Collin Meta Sterns Ronald N. Warrener 《Tetrahedron letters》1979,20(43):4229-4232
9-Hydroxy-1,4-anthraquinone, a benzannelated juglone derivative, undergoes regiospecific cycloaddition with isoprene when conducted in the presence of boron triacetate. The structure of this regiomer has been determined by X-ray crystallography. 相似文献
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Irene U. Osisioma Mutindi Mumbua Kiluva‐ndunda Meta Van Sickle 《School science and mathematics》2008,108(8):389-400
Three mathematics and science educators reexamine and reflect on their teaching within the context of the American Association for the Advancement of Sciences (AAAS) and National Council of Mathematics' call to make math and science education accessible to all. The paper highlights the importance of teachers reflecting on their teaching practices in order to create opportunities for their students especially those in the urban setting. The educators argue that teachers' reflection on their teaching can cause them to recognize and validate their students' ways of knowing as they identify the students' hidden/concealed abilities that are often masked by their behaviors. The educators discuss their experiences and highlight the lessons that they learned about ways to prepare teachers to successfully teach math and science students in urban settings. Culturally responsive pedagogy and cultural competency are critical skills that teachers need to develop in order to teach all children, especially those in the math and science classroom in the urban setting. 相似文献
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John A. Broomhead Nishat A. Pasha Carol A. Soloff Will L. Steffen Meta Sterns 《Transition Metal Chemistry》1987,12(4):361-365
Summary Acis- configuration for the [RuCl2(trien)]Cl·2H2O (trien=1, 8-diamino-3, 6-diazaoctane) complex has been confirmed by an x-ray crystal structure determination. Crystals are monoclinic, space group P21/c witha=7.336 (1),b=8.477 (2),c=23.181 (4) Å, =103.3 (1)°, U=1403 (1) Å.3 Z=4 and M=389.7, Dc=1.84 g cm–3. The structure was refined by full matrix least squares methods to final residual values of R=0.025 and Rw=0.033 on the basis of 3882 unique reflections. The complex has been resolved into its optical isomers using the (+)1, 2-diaminoethanebis(oxalato)cobaltate(III) anion and the absolute configuration assigned. 相似文献
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Meta Sterns 《Journal of chemical crystallography》1971,1(6):383-387
The crystal structure of di--methoxo-bis(chloro-2-methylpyridine copper(II)), [CuCl(OCH3)-(2-mepy)]2, has been determined from three-dimensional, photographically recorded X-ray data. The unit cell is monoclinic, space groupP21/c, with dimensionsa = 8·79,b = 6·01,c = 17·59 Å, = 104·4° and contains two centrosymmetric dimeric units [CuCl(OCH3). (2-mepy)]2, in which the copper atoms are linked by methoxide oxygen bridges, the dimers being joined into infinite chains through long copper-chlorine bonds. The environment of each copper atom may be described as a distorted tetragonal pyramid with one chlorine, one nitrogen and two oxygen atoms in the base and a chlorine atom from an adjacent dimer at the apex. 相似文献