The Parkinson larynx: Tremor and videostroboscopic findings

Patients with Parkinson's disease have a high incidence of speech, voice, and laryngeal abnormalities. To characterize laryngeal abnormalities, visual-perceptual ratings of endoscopic and stroboscopic examinations of 22 patients diagnosed with idiopathic Parkinson's disease and 7 patients with Parkinson's-plus syndromes were carried out by four trained viewers. Incidence of tremor, tremor location, phase closure, phase symmetry, amplitude, and mucosal waveform were scored. Tremor was observed in one or more of these conditions—rest, normal pitch and loudness, or loud phonation—for most of the 29 patients. Fifty-five percent of the idiopathic Parkinson's disease patients had tremor, with the primary location being vertical laryngeal tremor. Sixty-four percent of the Parkinson's-plus patients had tremor, with the arytenoid cartilages being the primary location. Laryngeal tremor was observed early in the disease in these Parkinson's disease patients. The most striking stroboscopic findings for the idiopathic Parkinson's disease patients were abnormal phase closure and phase asymmetry. Amplitude and mucosal wave-form were essentially within normal limits in the majority of the idiopathic Parkinson patients.     

Nanosecond optical parametric oscillator based on large-aperture periodically poled RbTiOAsO(4)

We report on optical parametric oscillators (OPO's) based on periodically poled RbTiOAsO(4) (PP RTA), which are pumped by Q -switched solid-state lasers. With a diode-pumped Nd:YVO(4) laser (pulse energy, 800microJ ; pulse duration, 5.5 ns; repetition rate, 1 kHz) the PP RTA OPO generated 1.58-microm signal and 3.26-microm idler radiation with a signal pulse energy of 45microJ . The large aperture of 3 mmx3 mm of the PP RTA crystal also permitted OPO operation with pump pulse energies as high as 65 mJ, provided by a flash-lamp-pumped Q -switched Nd:YAG laser (pulse duration, 20 ns; repetition rate, 10 Hz). With this pump source the OPO generated signal pulse energies as high as 17 mJ, corresponding to an efficiency of 26%. The performance of this OPO shows that large-aperture PP RTA crystals are well suited for pulsed nanosecond OPO operation with pump pulse energies of tens of millijoules.     

Second-order time evolution of PN equations for radiation transport

Using polynomials to represent the angular variation of the radiation intensity is usually referred to as the P_N or spherical harmonics method. For infinite order, the representation is an exact solution of the radiation transport solution. For finite N, in some physical situations there are oscillations in the solution that can make the radiation energy density be negative. For small N, the oscillations may be large enough to force the material temperature to numerically have non-physical negative values. The second-order time evolution algorithm presented here allows for more accurate solutions with larger time steps; however, it also can resolve the negativities that first-order time solutions smear out. Therefore, artificial scattering is studied to see how it can be used to decrease the oscillations in low-order solutions and prevent negativities. Small amounts of arbitrary, non-physical scattering can significantly improve the accuracy of the solution to test problems. Flux-limited diffusion solutions can also be improved by including artificial scattering. One- and two-dimensional test results are presented.     

An Isserlis’ Theorem for Mixed Gaussian Variables: Application to the Auto-Bispectral Density

This work derives a version of Isserlis’ theorem for the specific case of four mixed-Gaussian random variables. The theorem is then used to derive an expression for the auto-bispectral density for quadratically nonlinear systems driven with mixed-Gaussian iid noise. C.C. Olson is a NRC Postdoctoral Research Associate.     

Thermochemistry of Binding of Lead(II) and Cadmium(II) by Saccharides in Aqueous Solution

Solution calorimetry was used to determine enthalpies and stability constants for binding of lead(II) or cadmium(II) by galacturonic acid and several monosaccharides in aqueous solution. New values for enthalpies of solution in water are reported for galacturonic acid and maltose monohydrate. The interaction of water solvent with the reactants is the largest factor in the binding process.     

Halophilic reactions of a stable silylene with chloro and bromocarbons

A number of disilanes have been synthesized from a stable silylene, 1 (N,N'-di-tert-butyl-1,3-diaza-2-silacyclopent-4-en-2-ylidene), and a variety of halocarbons. It is proposed that disilane formation is a result of an initial halophilic interaction between the silylene and halocarbon. Formation of disilanes from 1 and CCl4, 2a, CHCl3, 2b, CH2Cl2, 2c, benzyl chloride, 2d, and bromobenzene, 5, are described here. An X-ray crystal structure of 2b was determined.