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791.
María S. Shmidt Isabel A. Perillo Mercedes González María M. Blanco 《Tetrahedron letters》2012,53(20):2514-2517
The reaction of isatin (1) with different alkyl halides 2 and alkaline carbonates in aprotic polar solvents leads mainly to N-alkyl derivatives 3. The use of alkylating agents that have acidic methylenes leads to competitive formation of the corresponding epoxide 5. The formation of 5 is favored by low-polarity solvents at low temperatures and strong bases. Epoxides 5c, d obtained using NaEtOH/EtOH at 0–5 °C are transformed into the corresponding 4-quinolinones 6 at higher temperatures. The use of Ag2CO3 allows obtaining compounds 3 as major products, along with varying amounts of labile O-alkyl derivatives 4 and dimerization products. 相似文献
792.
Assessing eco-efficiency with directional distance functions 总被引:1,自引:0,他引:1
Andrés J. Picazo-Tadeo Mercedes Beltrán-Esteve José A. Gómez-Limón 《European Journal of Operational Research》2012
Eco-efficiency is a matter of concern at present that is receiving increasing attention in political, academic and business circles. Broadly speaking, this concept refers to the ability to create more goods and services with less impact on the environment and less consumption of natural resources, thus involving both economic and also ecological issues. In this paper we propose the use of directional distance functions and Data Envelopment Analysis techniques to assess eco-efficiency. More specifically, we show how these functions can be used to compute a wide range of indicators representing different objectives regarding economic and ecological performance. This methodological approach is applied to a sample of Spanish olive-growing farms to illustrate its great potential to provide policymakers and farm managers with sound information as a basis for strategic decision making. We also suggest further avenues to explore in this burgeoning line of research. 相似文献
793.
Alpha-1-acid glycoprotein (AGP) presents different forms, which may arise from differences in the amino acid sequence and/or in the glycosidic part of the protein. Changes in forms of AGP have been described in literature as a possible tumor marker. While most previous works have approached the study of glycopeptides and/or glycans obtained after fragmentation of the protein, in this work, a CZE method is developed to separate up to eleven peaks of intact forms of AGP. A computer program developed in our laboratory is used to select the migration parameters that make possible an accurate assignment of AGP peaks. Electropherograms of AGP samples purified from sera of cancer patients and healthy donors are qualitatively and quantitatively compared. Percentages of correct assignment of AGP peaks close to 100% are achieved by using either the migration time of each peak relative to that of the EOF marker or the effective electrophoretic mobility of the peaks. The computer program permits to select, among different hypotheses for peak allotment, that one providing the highest accuracy of assignment. In this way, some peaks with different charge-to-mass ratio and a different distribution of area percentage of AGP forms are observed when comparing samples from sick and healthy individuals. Thus, a method that permits to compare AGP forms existing in sera of individuals with different pathophysiological situations has been developed. A potential for using AGP forms analyzed by CZE as a disease marker and for using this technique for screening purposes is envisaged. 相似文献
794.
795.
Alcalde MA Gancedo C Jover A Carrazana J Soto VH Meijide F Tato JV 《The journal of physical chemistry. B》2006,110(27):13399-13404
An amino derivative of beta-cyclodextrin [6-(6-aminehexanamide)-6-deoxy)-beta-cyclodextrin (6-betaCD)] was synthesized, and the formation of an intramolecular inclusion complex was studied by NMR techniques. The deprotonation/protonation of the amino group stimulates an in/out movement of the pendant group toward/from the cyclodextrin cavity, the protonated species lying outside the hydrophobic cyclodextrin cavity but the unprotonated one residing inside and outside the cavity. The protonation of the amino group is a fast exchange rate NMR time-scale process, but the chain movement is a slow one. The equilibrium constants of both processes were determined from 1H NMR experiments and the kinetic constants for the slow process were determined from exchange spectroscopy (EXSY) experiments. 相似文献
796.
Manetti F Tintori C Armand-Ugón M Clotet-Codina I Massa S Ragno R Esté JA Botta M 《Journal of chemical information and modeling》2006,46(3):1344-1351
The HIV-1 entry process is an important target for the design of new pharmaceuticals for the multidrug therapy of AIDS. A lot of polyanionic compounds, such as polysulfonated and polysulfated, are reported in the literature for their ability to block early stages of HIV-1 replication. Several studies have been performed to elucidate the mechanism of the anti-HIV-1 activity of sulfated polysaccharides and polyanions in general, including binding to cell surface CD4 and interfering with the gp120-coreceptor interaction. Here, we show molecular modeling investigations on ADS-J1, a polyanionic compound with anti-HIV activity that is able to interfere with gp120-coreceptor interactions. Agreeing with experimental data, computer simulations suggested that the V3 loop of gp120 was the preferential binding site for ADS-J1 onto HIV-1. Moreover, mutations induced by the inhibitor significantly changed the stereoelectronic properties of the gp120 surface, justifying a marked drop in the affinity of ADS-J1 toward an ADS-J1-resistant HIV-1 strain. 相似文献
797.
A simple and novel SPE system for benzene, toluene, ethylbenzene, and xylene isomers (BTEX) compounds in water is proposed in which samples are directly propelled from a 15 mL glass vial through a sorbent column by means of a needle, thereby avoiding evaporative losses and the sorption of BTEX on the manifold materials. Following elution with 150 microL of ethyl acetate, 1 microL of extract is injected into a gas chromatograph-mass spectrometer system. A comparative study of various sorbent materials (C60 fullerene, Tenax TA, and RP-C18) revealed C60 fullerene to be the best choice in terms of sensitivity (a likely result of its increased sample breakthrough volume), precision (the surfactant medium used to prepare samples minimizes evaporative losses), selectivity (C60 fullerene only interacts with nonpolar aromatic compounds), and reusability (columns containing 60 mg of C60 fullerene remain serviceable for at least 6 months). This C60 fullerene-based method exhibits a linear range of 0.1-100 microg/L, a detection limit of 0.04 microg/L, and an RSD of ca. 3%. It was applied to the determination of BTEX in various types of water including sea and waste water with good precision. 相似文献
798.
Aprile C Boronat M Ferrer B Corma A García H 《Journal of the American Chemical Society》2006,128(26):8388-8389
Organogold compounds arising from the trapping of carbon-centered radicals by gold chlorides (AuCl, AuCl3, and HAuCl4) and colloidal gold have been characterized by different spectroscopic techniques. Laser flash photolysis has provided kinetic evidence of the occurrence of radical trapping in the microsecond time scale, while theoretical calculations give the energetics of the elementary steps. The trapping of carbon radicals by gold species observed here may explain why the presence of radical initiators enhance dramatically the activity of gold catalysts for some reactions occurring through radical intermediates. 相似文献
799.
Roca-Sanjuán D Rubio M Merchán M Serrano-Andrés L 《The Journal of chemical physics》2006,125(8):084302
Quantum chemical high level ab initio coupled-cluster and multiconfigurational perturbation methods have been used to compute vertical and adiabatic ionization potentials of the five canonical DNA and RNA nucleobases: uracil, thymine, cytosine, adenine, and guanine. Several states of their cations have been also calculated. The present results represent a systematic compendium of these magnitudes, establishing theoretical reference values at a level not reported before, calibrating computational strategies, and guiding the assignment of the features in the experimental photoelectron spectra. 相似文献
800.
Soteras I Lozano O Gómez-Esqué A Escolano C Orozco M Amat M Bosch J Luque FJ 《Journal of the American Chemical Society》2006,128(20):6581-6588
The origin of the diastereoselective alkylation of enolates of oxazolopiperidones is studied by means of theoretical calculations and experimental assays. For the unsubstituted oxazolopiperidone, the alkylation with methyl chloride is predicted to afford mainly the exo product, a finding further corroborated from the analysis of the experimental outcome obtained in the reaction of the racemic oxazolopiperidone. However, such a preference can be drastically altered by the presence of substituents attached to the fused ring. In particular, when the angular carbon adopts an R configuration in a phenylglycinol-derived oxazolopiperidone, the presence of a phenyl ring at position 3 forces the pseudo-planarity of the bicyclic lactam, and the diastereoselectivity is dictated by the internal torsional strain induced in the enolate. However, when the angular carbon adopts an S configuration, the preference for the exo alkylation stems from the intermolecular steric hindrance between the enolate and the alkylating reagent. Interestingly, the intramolecular hydrogen bond formed between the phenyl ring and the carbonyl oxygen in the enolate largely reduces the difference in stability of the two TSs compared to the unsubstituted oxazolopiperidone. 相似文献