Microtubules perform a variety of functions which lead to the complex regulation of intracellular transport and cell division. However, the regulation of microtubule growth is not clearly known. Based on a recent experimental finding, we explore the possibility of spatial regulation of microtubule growth by stathmin–tubulin interaction gradients. Computer simulation of the model with stathmin–tubulin interaction gradients gave regulated growth as seen in experiments. In future, the stathmin–tubulin interaction gradients can be made dynamic and its impact on the microtubule growth can be explored. 相似文献
A highly soluble poly(1,3,4‐oxadiazole) (POD) substituted with long alkyl chains was examined for electrochemical fluorescence switching. The high solubility of the polymers enabled a simple fabrication of an electrochemical cell, which showed reversible fluorescence switching between dark (n‐doping) and bright (neutral) states with a maximum on/off ratio of 2.5 and a cyclability longer than 1 000 cycles. Photochemical cleavage of the oxadiazole in POD allowed photo‐patterning of the POD film upon exposure to UV source. The patterned POD films displayed patterned image reversibly under a step potential of +1.8/−1.8 V.