Grafting onto Gelatin. II. Graft Copolymerization of Ethyl Acrylate and Methyl Methacrylate onto Gelatin in the Presence of Ce4+ as Redox Initiator

In order to initiate a comprehensive study of graft copolymerization of vinyl monomers onto soluble protein-gelatin, we have studied grafting of ethyl acrylate (EA) and methyl methacrylate (MMA) onto gelatin using eerie ammonium nitrate (CAN) and eerie ammonium sulfate (CAS) as the redox initiator in an aqueous medium. A small amount of mineral acid (HNO₃ with CAN and H2SO4 with CAS) was found to catalyze the graft copolymerization. Graft copolymerization reactions were carried out at different temperatures. Maximum grafting occurred at 65°C both with EA and MMA. Percentage grafting has been determined as function of 1) concentration of monomer (EA and MMA), 2) concentration of initiator (CAN and CAS), 3) concentration of acid (HNO3 and H2SO4), 4) time, and 5) temperature.     

Mild,Rapid, and Inexpensive Microwave-Assisted Synthesis of Allylic and Propargylic Esters

A variety of allylic and propargylic esters were rapidly prepared via microwave heating of their corresponding mixed anhydride derived from pivaloyl chloride. The reaction conditions were modified to account for the sterics of the alcohol and the electronics of the carboxylic acid.

Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.     

Synthesis and Antimicrobial Screening of Some Novel Chromones and Pyrazoles with Incorporated Isoxazole Moieties

The title compounds 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h and 6a , 6b , 6c , 6d , 6e , 6f , 6g , 6h have been synthesized from β‐diketones and chromones, respectively, having 5‐methyl‐3‐phenylisoxazole moiety. Substituted 2‐acetylphenyl 5‐methyl‐3‐phenylisoxazole‐4‐carboxylate 3a , 3b , 3c , 3d , 3e , 3f , 3g , 3h were converted into 1‐(2‐hydroxyphenyl)‐3‐(5‐methyl‐3‐phenylisoxazole‐4‐yl)propane‐1,3‐dione 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h by Baker–Venketaraman transformation. Further, the cyclodehydration of diketone 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h with glacial acetic acid in conc. HCl at reflux gave corresponding substituted 2‐(5‐methyl‐3‐phenylisoxazole‐4‐yl)‐4H‐chromen‐4‐one 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h . The corresponding 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h react with hydrazine hydrate in presence of glacial acetic acid in ethanol at reflux to furnish 2‐(5‐5(5‐methyl‐3‐phenylisoxazole‐4‐yl)‐1H‐pyrazole‐3‐yl)phenol 6a , 6b , 6c , 6d , 6e , 6f , 6g , 6h . The structures of all newly synthesized compounds have been confirmed by IR, ¹H NMR, mass spectral data, as well as elemental analysis. The synthesized compounds have been screened for their antimicrobial activity. Some of the compounds show better antimicrobial activity as compared with the reference drugs Streptomycin, Ampicillin, Gentamycin, Cefixime, and Ketoconazole.     

Observation of B-->eta'K* and evidence for B+-->eta'rho+

We present an observation of B-->eta'K*. The data sample corresponds to 232x10(6) BB[over ] pairs collected with the BABAR detector at the PEP-II asymmetric-energy B factory at the Stanford Linear Accelerator Center. We measure the branching fractions (in units of 10(-6)) B(B(0)-->eta'K*0)=3.8+/-1.1+/-0.5 and B(B+-->eta'K*+)=4.9(1.7)(+1.9)+/-0.8, where the first error is statistical and the second systematic. A simultaneous fit results in the observation of B-->eta'K* with B(B-->eta'K*)=4.1(-0.9)(+1.0)+/-0.5. We also search for B-->eta'rho and eta'f(0)(980)(f(0)-->pi+pi-) with results and 90% confidence level upper limits B(B+-->eta'rho+)=8.7(-2.8-1.3)(+3.1+2.3) (<14), B(B(0)-->eta'rho0)<3.7, and B(B(0)-->eta'f(0)(980)(f(0)-->pi+pi-))<1.5. Charge asymmetries in the channels with significant yields are consistent with zero.     

Heart Regeneration: Opportunities and Challenges for Drug Discovery with Novel Chemical and Therapeutic Methods or Agents

Following a heart attack, more than a billion cardiac muscle cells (cardiomyocytes) can be killed, leading to heart failure and sudden death. Much research in this area is now focused on the regeneration of heart tissue through differentiation of stem cells, proliferation of existing cardiomyocytes and cardiac progenitor cells, and reprogramming of fibroblasts into cardiomyocytes. Different chemical modalities (i.e. methods or agents), ranging from small molecules and RNA approaches (including both microRNA and anti‐microRNA) to modified peptides and proteins, are showing potential to meet this medical need. In this Review, we outline the recent advances in these areas and describe both the modality and progress, including novel screening strategies to identify hits, and the upcoming challenges and opportunities to develop these hits into pharmaceuticals, at which chemistry plays a key role.     

Measurement of B0-B-0 flavor oscillations in hadronic B0 decays

Flavor oscillations of neutral B mesons have been studied in e+e- annihilation data collected with the BABAR detector at center-of-mass energies near the upsilon(4S) resonance. The data sample used for this purpose consists of events in which one B0 meson is reconstructed in a hadronic decay mode, while the flavor of the recoiling B0 is determined with a tagging algorithm that exploits the correlation between the flavor of the heavy quark and the charges of its decay products. From the time development of the observed mixed and unmixed final states, we determine the B0-B-0 oscillation frequency deltamd to be 0.516+/-0.016(stat)+/-0.010(syst) ps-1.     

Measurement of B --> K*gamma branching fractions and charge asymmetries

The branching fractions of the exclusive decays B0-->K(*0)gamma and B+-->K(*+)gamma are measured from a sample of (22.74+/-0.36)x10(6) BB decays collected with the BABAR detector at the PEP-II asymmetric e(+)e(-) collider. We find B (B0-->K(*0)gamma) = [4.23+/-0.40(stat)+/-0.22(syst)]x10(-5), B(B+-->K(*+)gamma) = [3.83+/-0.62(stat)+/-0.22(syst)]x10(-5) and constrain the CP-violating charge asymmetry to be -0.170K(*)gamma)<0.082 at 90% C.L.     

Large-Scale Regularities of Lattice Embeddings of Posets

Let N denote the set of natural numbers and let P =(N ^k , ) be a countably infinite poset on the k-dimensional lattice N ^k . Given x N ^k , we write max(x) (min(x)) for the maximum (minimum) coordinate of x. Let be the directed-incomparability graph of P which is defined to be the graph with vertex set equal to N ^k and edge set equal to the set of all (x, y) such that max(x) max(y) and x and y not comparable in P. For any subset D N ^k , we let P _D and _D denote the restrictions of P and to D. Points x N ^k with min(x) = 0 will be called boundary points. We define a geometrically natural notion of when a point is interior to P or relative to the lattice N ^k , and an analogous notion of monotone interior with respect to or _D . We wish to identify situations where most of these interior points are exposed to the boundary of the lattice or, in the case of monotone interior points, not concealed very much from the boundary. All of these ideas restrict to finite sublattices F ^k and/or infinite sublattices E ^k of N ^k . Our main result shows that for any poset P and any arbitarily large integer M > 0, there is an F E with F = M where, relative to the sublattices F ^k E ^k , the ideal situation of total exposure of interior points and very little concealment of monotone interior points must occur. Precisely, we prove that for any P =(N ^k , ) and any integer M > 0, there is an infinite E N and a finite D F ^k with F E and F = M such that (1) every interior vertex of P _{E k} or _{E k} is exposed and (2) there is a fixed set C E, C k ^k , such that every monotone-interior point of _D belonging to F ^k has its monotone concealment in the set C. In addition, we show that if P ¹ =(N ^k , ₁),..., P ^r =(N ^k , _r ) is any sequence of posets, then we can find E,D, and F so that the properties (1) and (2) described above hold simultaneously for each P ⁱ . We note that the main point of (2) is that the bound k ^k depends only on the dimension of the lattice and not on the poset P. Statement (1) is derived from classical Ramsey theory while (2) is derived from a recent powerful extension of Ramsey theory due to H. Friedman and shown by Friedman to be independent of ZFC, the usual axioms of set theory. The fact that our result is proved as a corollary to a combinatorial theorem that is known to be independent of the usual axioms of mathematics does not, of course, mean that it cannot be proved using ZFC (we just couldn"t find such a proof). This puts our geometrically natural combinatorial result in a somewhat unusual position with regard to the axioms of mathematics.     

Fermilab top mass and modified Fritzsch mass matrices

Fritzsch like mass matrices with non-zero 22-elements both in U sector and D sector have been investigated in the context of latest data regardingm _t ^phys , |V _ub|, |V _cb|, |V _td| and |V _ts|. Unlike several other phenomenological models, the present model not only accommodates the value ofm _t ^phys in the range 150–240 GeV, encompassing the CDF and D0 values, but is also able to reproduce |V _cb| ≊0.040 and |V _ub/V_cb| = 0.08±0.02 and |V _td| is predicted to lie in the range 0.005–0.014. Further, the angles of the unitarity triangle, related to the CP-violating asymmetries, are calculated to be in the ranges −1.0⩽sin2α⩽−0.1, 0.6 ⩽sin2α⩽1.0 and 0.48⩽sin2β⩽0.56, which are in agreement with other recent calculations.     

Studies in metal sulphite chemistry—III

Manganese(II) iodide, iron(II) iodide and copper(I) iodide each react with tetramethylammonium disulphite to form anhydrous manganese(II) sulphite, iron(II) sulphite and copper(I) disulphite respectively. Iron(II) sulphite and copper(I) disulphite react with dimethylsulphoxide-sulphur dioxide to form iron(II) disulphate and copper(II) disulphate respectively. Hydrated sulphites of manganese(II), iron(II), magnesium(II) and calcium(II) were also prepared. The properties of the sulphites were investigated using thermogravimetric and IR measurements.