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991.
In the non-inertial coordinates attached to the model wing, the two-dimensional unsteady flow field triggered by the motion of the model wing, similar to the flapping of the insect wings, was numerically simulated. One of the advantages of our method is that it has avoided the difficulty related to the moving-boundary problem. Another advantage is that the model has three degrees of freedom and can be used to simulate arbitrary motions of a two-dimensional wing in plane only if the motion is known. Such flexibility allows us to study how insects control their flying. Our results show that there are two parameters that are possibly utilized by insects to control their flight: the phase difference between the wing translation and rotation, and the lateral amplitude of flapping along the direction perpendicular to the average flapping plane. 相似文献
992.
IntroductionHowtheintensionandmoduleofsteelfibrereinforcedconcrete (SFRC)dependsonitsconstituentpropertiesandcontentisaprincipalproblemtopredictmacro_mechanicspropertiesofSFRC,thekeyconsistsintheconfirmationofstressdistribution .Interfacialstresstransfe… 相似文献
993.
THEHAMILTONIANSTBUCTURESOF3DODEWITHTIME-INDEPENDENTINVARIANTSGuoZhong-heng(郭仲衡)(DepartmentofMathematics,PekingUniversity,Beij... 相似文献
994.
加注稀土元素铒改善轴承表面性能的研究 总被引:2,自引:0,他引:2
在Mo^++N^+注入模式的基础上,应用电子能谱、卢瑟福背散射谱、扫描电子显微镜和MHK-500型摩擦磨损试验机等研究了加注稀土元素铒正离子Er^+对轴承表面摩擦学性能和耐蚀性能的影响。结果表明,在合理配置Mo^+、N^+、Er^+之能量和剂量的情况下,加注Er^+既能更好地改善轴承的表面性能,又能使重离子的强韧化效果提高2-4倍以上,表明MO^++N^++Er^+注入模式是一种具有良好应用前景的 相似文献
995.
Synthesis and Design of Aggregation‐Induced Emission Surfactants: Direct Observation of Micelle Transitions and Microemulsion Droplets 下载免费PDF全文
Dr. Weijiang Guan Dr. Wenjuan Zhou Prof. Dr. Chao Lu Prof. Dr. Ben Zhong Tang 《Angewandte Chemie (International ed. in English)》2015,54(50):15160-15164
The direct visualization of micelle transitions is a long‐standing challenge owing to the intractable aggregation‐caused quenching of light emission in the micelle solution. Herein, we report the synthesis of a surfactant with a tetraphenylethene (TPE) core and aggregation‐induced emission (AIE) characteristics. The transition processes of surfactant micelles and the microemulsion droplets (MEDs) formed by the surfactant with a TPE core were clearly visualized by a high‐contrast fluorescence imaging method. The fluorescence intensity of the MEDs decreased as the size of MEDs increased as a result of weakening of the restriction of intramolecular rotation (RIR). The results of this study deepen our understanding of micelle‐transition processes and provide solid evidence in favor of the hypothesis that the AIE phenomenon has its origin in the RIR of fluorophores in the aggregate state. 相似文献
996.
A Molecular Platform for Multistate Near‐Infrared Electrochromism and Flip‐Flop,Flip‐Flap‐Flop,and Ternary Memory 下载免费PDF全文
Bin‐Bin Cui Jian‐Hong Tang Jiannian Yao Yu‐Wu Zhong 《Angewandte Chemie (International ed. in English)》2015,54(32):9192-9197
A diruthenium complex with a redox‐active amine bridge has been designed, synthesized, and studied by single‐crystal X‐ray analysis and DFT and TDDFT calculations. It shows three well‐separated redox processes with exclusive near‐infrared (NIR) absorbance at each redox state. The electropolymerized film of a related vinyl‐functionalized complex displays multistate NIR electrochromism with low operational potential, good contrast ratio, and long retention time. Flip‐flop, flip‐flap‐flop, and ternary memories have been realized by using the obtained film (ca. 15–20 nm thick) with three electrochemical inputs and three NIR optical outputs that each displays three levels of signal intensity. 相似文献
997.
998.
A Preloaded Amorphous Calcium Carbonate/Doxorubicin@Silica Nanoreactor for pH‐Responsive Delivery of an Anticancer Drug 下载免费PDF全文
Dr. Yang Zhao Dr. Zhong Luo Menghuan Li Qiuyu Qu Xing Ma Prof. Shu‐Hong Yu Prof. Yanli Zhao 《Angewandte Chemie (International ed. in English)》2015,54(3):919-922
Biomedical applications of nontoxic amorphous calcium carbonate (ACC) nanoparticles have mainly been restricted because of their aqueous instability. To improve their stability in physiological environments while retaining their pH‐responsiveness, a novel nanoreactor of ACC–doxorubicin (DOX)@silica was developed for drug delivery for use in cancer therapy. As a result of its rationally engineered structure, this nanoreactor maintains a low drug leakage in physiological and lysosomal/endosomal environments, and responds specifically to pH 6.5 to release the drug. This unique ACC–DOX@silica nanoreactor releases DOX precisely in the weakly acidic microenvironment of cancer cells and results in efficient cell death, thus showing its great potential as a desirable chemotherapeutic nanosystem for cancer therapy. 相似文献
999.
Identification of Structure–Activity Relationships from Screening a Structurally Compact DNA‐Encoded Chemical Library 下载免费PDF全文
Dr. Raphael M. Franzini Dr. Torun Ekblad Dr. Nan Zhong Moreno Wichert Willy Decurtins Angela Nauer Mauro Zimmermann Dr. Florent Samain Dr. Jörg Scheuermann Dr. Peter J. Brown Prof. Dr. Jonathan Hall Dr. Susanne Gräslund Prof. Dr. Herwig Schüler Prof. Dr. Dario Neri 《Angewandte Chemie (International ed. in English)》2015,54(13):3927-3931
Methods for the rapid and inexpensive discovery of hit compounds are essential for pharmaceutical research and DNA‐encoded chemical libraries represent promising tools for this purpose. We here report on the design and synthesis of DAL‐100K, a DNA‐encoded chemical library containing 103 200 structurally compact compounds. Affinity screening experiments and DNA‐sequencing analysis provided ligands with nanomolar affinities to several proteins, including prostate‐specific membrane antigen and tankyrase 1. Correlations of sequence counts with binding affinities and potencies of enzyme inhibition were observed and enabled the identification of structural features critical for activity. These results indicate that libraries of this type represent a useful source of small‐molecule binders for target proteins of pharmaceutical interest and information on structural features important for binding. 相似文献
1000.
Two new xanthones, designated garcimangosxanthone F (1) and garcimangosxanthone G (2), were isolated from the EtOAc-soluble fraction of ethanolic extract from the pericarp of Garcinia mangostana. Their structures were established as 1,6,7-trihydroxy-5-(3-methylbut-2-enyl)-8-(3-hydroxy-3-methylbutyl)-6′,6′-dimethylpyrano[2′,3′:3,2]xanthone and 1,6,7-trihydroxy-5-(3-methylbut-2-enyl)-8-(3-hydroxy-3-methylbutyl)-6′,6′-dimethyl-4′,5′-dihydropyrano[2′,3′:3,2]xanthone, respectively, on the basis of their 1D, 2D NMR and MS data interpretation. 相似文献