锌制剂“维宝康”治疗儿童缺锌综合征的临床研究

用维宝康治疗小儿缺锌综合征９８例,结果表明,服用维宝康一个疗程后,患者临床症状明显改善发锌值升高,总有效率为９６％,未见毒副作用,是较好的补锌制剂。     

Unlabeled Fluoroimmunoassay with a Europium Chelate

Unlabeled fluoroimmunoassay with a europium chelate is described. The recommended method is simple because the complicated labeling process is omitted. The recovery of some samples ranges from 91 to 111%. The relative standard deviation of the method is less than 10%. The detection limit is about 10⁻¹⁰mol liter⁻¹antigen.     

Two novel dicoumaro-p-menthanes from Gerbera piloselloides (L.) CASS

Two new type dicoumarins (dicoumaro-p-menthanes), named dibothrioclinins I (1) and II (2) were isolated from the roots and rhizomes of Gerbera piloselloides (L.) CASS., collected in Yunnan Province, China. Their structures were elucidated on the basis of MS, 1D ((1)H-NMR, (13)C-NMR, DEPT and NOE) and 2D ((1)H-(1)H COSY, HMQC, HMBC) NMR spectral analyses. The relative structures of the two compounds were established by NOE difference spectroscopy and further confirmed by single-crystal X-ray diffraction studies.     

低压催化氚化亮石松碱的定位效应的研究

近年来,中草药有效成分的研究引起国内外有关学者普遍关注。氚标记中草药有效成分是研究其相应的药代动力学和代谢产物的主要手段,它具有操作简便,条件温和等优点,但是一般氚化方法均不能明确给出氚化位置。而研究氚化定位效应又是药理工作者急待解决的重要课题,所以在很大程度上限制了该项技术的使用范围。最近,郑冬珠等人用FX—100型核磁共振谱仪给出了在PdO催化剂存在条件下,低压氚化亮石松碱的氚化位置及其相对含量。本文在前文基础上,以亮石松碱为底物,根据Fraser和Garnett等人提出的氢—氚同位素交换反应动力学理论,采用CNDO/2法,对PdO催化亮石松碱的立体构型讲行了计算,得出一些有意义的结果。     

压缩X因子导数光谱法测定痕量锗

本采用压缩Ｘ因子导数光谱技术实现了宽峰体系灵敏度的大幅度提高，提出了测定痕量锗的方法。在０．７２ｍｏｌ／ＬＨ２ＳＯ４和３．０ｍｏｌ／ＬＨ３ＰＯ４的混酸介质中，锗－水杨基荧光酮－ＯＰ三元显色体系的压缩Ｘ因子四阶导数光谱摩尔响应系数达１．８９×１０＾６Ｌ．ｍｏｌ＾－１．ｃｍ＾－１，灵敏度比常规光度法高１２．４倍；最低检测出限为０．０００３３ｍｇ／Ｌ，比常规光谱法低４倍；选择性也进一步提高，绝大多数离     

Quadrupole mass filters with octopole fields

The performance of quadrupole mass filters with added octopole fields in the range 2.0-4.0% has been investigated. The added fields are much greater than those normally added to conventional rod sets by mechanical tolerances or construction errors. Quadrupole rod sets with added octopole fields were constructed with round rods by making one pair of rods greater in diameter than the other pair. For positive ions, resolution at half height of only about 200 is possible if the negative direct current (dc) output of the quadrupole power supply is connected to the smaller rods. If the positive dc output of the quadrupole power supply is connected to the smaller rods, the resolution improves dramatically; a resolution at half height of 5800 has been observed with a rod set with 2.6% added octopole field. For negative ions the best resolution is obtained with the polarity of the dc reversed, i.e. with the negative dc applied to the smaller rods. These findings are unexpected in view of the literature that argues that to obtain high mass resolution with quadrupole mass filters, higher order multipoles must be kept as small as possible. Numerical simulations of peak shapes agree qualitatively with experiments. Simulation of the boundaries of the first stability region for positive ions shows that when the positive dc is applied to the smaller rods, the addition of a 2.0% octopole field causes the boundaries to shift slightly but the boundaries are well defined, and the tip of the stability region remains sharp. When the positive dc is applied to the larger rods, the boundaries of the stability region move out and become diffuse. For instruments that require a rod set that can be used both as a linear trap and a mass filter, these rod sets may offer improved trap performance while still being capable of providing conventional mass analysis.     

The Enhancement of Efficiency of High-order Harmonic in Intense Laser Field Based on Asymptotic Boundary Conditions and Symplectic Algorithm

Asymptotic boundary condition (ABC) of laser-atom interaction presented recently is applied to transform the initial value problem of the time-dependent Schrödinger equation (TDSE) in infinite space into the initial and boundary value problem in the finite space, and then the TDSE is discretized into linear canonical equations by substituting the symmetry difference quotient for the 2-order partial derivative. The canonical equation is solved by symplectic algorithm. The ground state and the equal weight coherent superposition of the ground state and the first excited state have been taken as the initial conditions, respectively, while we calculate the population of bound states, the evolution of average distance and the high-order harmonic generation (HHG). The conversion efficiency of HHG can be enhanced by initial coherent superposition state and moderate laser intensities     

Derivatization procedures for the detection of estrogenic chemicals by gas chromatography/mass spectrometry

This work evaluated derivatization procedures for detecting both natural and synthetic estrogenic chemicals by gas chromatography/mass spectrometry (GC/MS). Different silylating agents, mainly trimethylsilylating (TMS) agents, were compared, and the roles of various content of trimethylchlorosilane (TMCS, as a stimulator) were investigated. The difference in the abundances of the derivatives was caused by the steric hindrance of multiple hydroxyl groups and ethynyl groups in the structures of estrogenic chemicals. The use of TMCS produces an increase in the derivatization yield, especially for the compounds with multiple hydroxyl groups (i.e., 17beta-estradiol (E(2)) and estriol (E(3))). Mass spectra of O-TMS derivatives and tentative fragmentation profiles are proposed. Molecular ions were the base peaks for all the derivatives, and were used as the quantitation ions to obtain maximum detection sensitivity and specificity. Sample enrichment was achieved by Oasis HLB solid-phase extraction cartridges. The quantitation limits of these compounds ranged from 5 to 10 ng/L in 1000-mL water samples. Recovery of the estrogenic chemicals in spiked various water samples ranged from 78 to 102% while relative standard deviation (RSD) ranged from 1 to 15%.