Efficient synthesis of imidazo[1,2-a]pyridin-3(2H)-ones

2-Aminopyridines react with diaroylacetylenes to produce imidazo[1,2-a]pyridin-3(2H)-ones in good to excellent yields.     

Design,synthesis, in vivo and in vitro studies of 1,2,3,4-tetrahydro-9H-carbazole derivatives,highly selective and potent butyrylcholinesterase inhibitors

Molecular Diversity - Inhibition of butyrylcholinesterase (BChE) might be a useful therapeutic target for Alzheimer’s disease (AD). A new series of 1,2,3,4-tetrahydro-9H-carbazole derivatives...     

Zeolite HY and Silica Gel as New and Efficient Heterogenous Catalysts for the Synthesis of Triarylimidazoles under Microwave Irradiation

Summary.  Zeolite HY and silica gel efficiently catalyzed the three component condensation of benzil, benzaldehyde derivatives, and ammonium acetate under solvent-free conditions and microwave irradiation. Received February 22, 2000. Accepted (revised) March 22, 2000     

Novel Four‐Component Approach for the Synthesis of Polyfunctionalized 1,4‐Dihydropyridines in Aqueous Media

The four‐component reaction of dimethyl acetylenedicarboxylate (=dimethyl but‐2‐ynedioate; DMAD), aromatic aldehydes, and malononitrile (=propanedinitrile) leads to polyfunctionalized 1,4‐dihydropyridine derivatives. The reaction proceeds at room temperature and in the presence of a catalytic amount (20%) of (NH₄)₂HPO₄ as a base in aqueous media.     

Retracted: Effective and Green One‐Pot Multicomponent Synthesis of Novel Derivatives of 4H‐Pyrans in the Presence of Hexamethylenetetramine as Catalyst in Water Medium

Hexamethylenetetramine (HMTA) catalyzes synthesis of new polyfunctionalized 4H‐pyrans by reaction of aromatic aldehyde, malononitrile, and β‐keto esters via one‐pot three‐component procedure in water medium. Addition of reactants was performed by two methods led to achieve similar results. Using HMTA in catalytic amount not only represents the economic face of the reaction, but also due to the use of water, a green and safe reaction condition is organized. Thus, the current strategy provides the benefits of high productivity, convenient operation, and environmental friendliness. Structure of all products was proved by elemental analysis, IR, ¹H‐NMR, and ¹³C‐NMR spectroscopy.