Electrochemical Determination of Propranolol,Acetaminophen and Folic Acid in Urine,and Human Plasma Using Cu2O–CuO/rGO/CPE

Russian Journal of Electrochemistry - A Cu2O–CuO/rGO/CPE was used for simultaneous measurement of propranolol (PRO), Acetaminophen (AC) and folic acid (FA) using differential pulse...     

Effects of Fracture Boundary Conditions on Matrix-fracture Transfer Shape Factor

The matrix-fracture transfer shape factor is one of the important parameters in modeling naturally fractured reservoirs. Four decades after Warren and Root (1963, SPEJ, 245–255.) introduced the double porosity concept and suggested a relation for it, this parameter is still not completely understood. Even for a single-phase flow problem, investigators report different shape factors. This study shows that for a single-phase flow in a particular matrix block, the shape factor that Warren and Root defined is not unique and depends on the pressure in the fracture and how it changes with time. We use the Laplace domain analytical solutions of the diffusivity equation for different geometries and different boundary conditions to show that the shape factor depends on the fracture pressure change with time. In particular, by imposing a constant fracture pressure as it is typically done, one obtains the shape factor that Lim and Aziz (1995, J. Petrolean Sci. Eng. 13, 169.) calculated. However, other shape factors, similar to those reported in other studies are obtained, when other boundary conditions are chosen. Although, the time variability of the boundary conditions can be accounted for by the Duhamel’s theorem, in practice using large time-steps in numerical simulations can potentially introduce large errors in simulation results. However, numerical simulation models make use of a stepwise approximation of this theorem. It is shown in this paper that this approximation could lead to large errors in matrix-fracture transfer rate if large time-steps are chosen.     

Fabrication of high thermal stable cured novolac/Cloisite 30B nanocomposites by chemical modification of resin structure

Cloisite 30B as a modified kind of nanoclay was utilized for the formation of 3D network based on novolac resin with high thermal stable properties. Two types of phenolic resins including neat novolac (NR) and modified novolac resin were used to create a compatible matrix with nanoclay. For this purpose, NR modified with (3‐chloropropyl)triethoxysilane (CPTES) to form SiNR. For improvement of thermal behaviors, Cloisite 30B was dispersed in matrix via ultrasonic waves and cured with hexamethylenetetramine (HMTA) to form 3D network. X‐ray diffraction (XRD) analysis was used to measure the d‐spacing in intercalated systems and results indicated the optimum amount of clay for appropriate thermal properties. Investigation of the thermal properties of the samples by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) showed that the presence of Cloisite 30B in matrix resulted in much higher thermal stability and char yield with respect to modification of novolac resin originated from formation of 3D Si–O–Si network. Also, cured modified resin and its nanocomposites showed much higher thermal stability than cured NR and its nanocomposites. Such nanocomposite materials with high thermal stability have potential applications in advanced fields such electronic, industrial molds, coatings, adhesives, and aerospace composites.     

脂肪胺水溶液吸收CO2的热力学参数的密度泛函理论研究

采用密度泛函理论研究CO2在脂肪胺水溶液热力学参数．研究的脂肪胺包括烷基胺、链烷醇胺、二胺以及氨基酰胺．在B3LYP/6-311＋ G（d,p）水平计算脂肪胺在CO2气相中的振动频率．通过连续介质模型在HF/6-31G（d）水平计算了溶剂几何优化的标准自由能,评价了CO2吸收到脂肪胺水溶液过程有关的两个重要参数：酸解离常数和标准焓变二者之间大致呈线性关系．随着胺碱度的提高,CO2吸收过程释放的热量增加,则胺再生所需的能量增加．     

Solution Construction to a Class of Riemann Problems of Multiphase Flow in Porous Media

Transport in Porous Media - Fluid displacement in porous media can usually be formulated as a Riemann problem. Finding the solution to such a problem helps shed light on the dynamics of flow and...     

Palladium nanoparticles immobilized on EDTA‐modified Fe3O4@SiO2 nanospheres as an efficient and magnetically separable catalyst for Suzuki and Sonogashira cross‐coupling reactions

In this study, a novel heterogeneous palladium catalyst was synthesized by anchoring palladium onto ethylenediaminetetraacetic acid (EDTA)‐coated Fe₃O₄@SiO₂ magnetic nanocomposite and used for the Suzuki and Sonogashira cross‐coupling reactions. The properties of the magnetic catalyst were characterized by FT‐IR, XRD, TEM, FE‐SEM, DLS EDX, XPS, N₂ adsorption‐desorption isotherm analysis, TGA, VSM, elemental analysis and the loading level of Pd in catalyst was measured to be 0.51 mmol/g by ICP. The catalyst was used in Suzuki cross‐coupling reactions of various aryl halides, including less reactive chlorobenzenes with phenylboronic acid without any additive or ligand under green conditions. Furthermore, we have reported this recyclable catalytic system for Sonogashira cross‐coupling reactions of various aryl halides (I, Br, Cl) under copper and ligand‐free conditions in the presence of DMF/H₂O (1:2/v:v) as a solvent. The magnetic catalyst could also be separated by an external magnet and reused six times without any significant loss of activity.     

Pd/MOF‐199: As an efficient heterogeneous catalyst for the Suzukie Miyaura cross‐coupling reaction

Successful deposition of Pd nanoparticles is described using MOF‐199 as a support. Various characterization techniques including FTIR, XRD, SEM, BET‐BJH, TG‐DTA, and NH₃‐TPD were used to verify the efficiency of catalysts. Pd/MOF‐199 is utilized as a catalyst for Suzukie Miyaura reactions with reasonable to excellent reaction yields under reflux conditions in H₂O: ethanol solvent.     

FemtoMolar measurements using accelerator mass spectrometry

Accelerator mass spectrometry (AMS) is an ultra‐sensitive analytical method suitable for the detection of sub‐nM concentrations of labeled biological substances such as pharmaceutical drugs in body fluids. A limiting factor in extending the concentration measurements to the sub‐pM range is the natural ¹⁴C content in living tissues. This was circumvented by separating the labeled drug from the tissue matrix, using standard high‐performance liquid chromatography (HPLC) procedures. As the separated total drug amount is in the few fg range, it is not possible to use a standard AMS sample preparation method, where mg sizes are required. We have utilized a sensitive carbon carrier method where a ¹⁴C‐deficient compound is added to the HPLC fractions and the composite sample is prepared and analyzed by AMS. Using 50 µL human blood plasma aliquots, we have demonstrated concentration measurements below 20 fM, containing sub‐amol amounts of the labeled drug. The method has the immediate potential of operating in the sub‐fM region. Copyright © 2009 John Wiley & Sons, Ltd.