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41.
42.
Tabassum Jannat Md. Jamal Hossain Ahmed M. El-Shehawi Md. Ruhul Kuddus Mohammad A. Rashid Sarah Albogami Ibrahim Jafri Mohamed El-Shazly Mohammad Rashedul Haque 《Molecules (Basel, Switzerland)》2022,27(13)
The aim of the study was to conduct phytochemical and pharmacological investigations of Wrightia coccinea (Roxb. ex Hornem.) Sims via several in vitro, in vivo, and in silico models. A total of four compounds were identified and isolated from the methanol extract of the bark and the methanol extract of the seed pulp of W. coccinea through successive chromatographic techniques and were characterized as 3β-acetyloxy-olean-12-en-28-ol (1), wrightiadione (2), 22β-hydroxylupeol (3), and β-sitosterol (4) by spectroscopic analysis. The aqueous fraction of the bark and chloroform fraction of the fruits provided the most potent antioxidant capacity (IC50 = 7.22 and 4.5 µg/mL, respectively) in DPPH free radical scavenging assay compared with the standard ascorbic acid (IC50 = 17.45 µg/mL). The methanol bark extract and the methanol fruit coat extract exerted anti-diarrheal activity by inhibiting 74.55 ± 0.67% and 77.78 ± 1.5% (mean ± SEM) of the diarrheal episode in mice, respectively, after four hours of loading the samples. In the hypoglycemic test, the methanol bark extract and the methanol fruit coat extract (400 mg/kg) produced a significant (p < 0.05) reduction in the blood glucose level in mice. Both doses of the plant extracts (200 mg/kg and 400 mg/kg) used in the study induced a significant (p < 0.05) increase in pain reaction time. The in vitro and in vivo findings were supported by the computational studies. The isolated compounds exhibited higher binding affinity compared with the standard drugs towards the active binding sites of glutathione reductase, epidermal growth factor receptor (EGFR), kappa opioid receptor, glucose transporter 3 (GLUT 3), Mu opioid receptor, and cyclooxygenase 2 (COX-2) proteins due to their potent antioxidant, cytotoxic, anti-diarrheal, hypoglycemic, and central and peripheral analgesic properties, respectively. The current findings concluded that W. coccinea might be a potential natural source for managing oxidative stress, diarrhea, hyperglycemia, and pain. Further studies are warranted for extensively phytochemical screening and establishing exact mechanisms of action. 相似文献
43.
Md. Zia Uddin Arkajyoti Paul Ahmed Rakib Saad Ahmed Sami Shafi Mahmud Md. Sohel Rana Shahadat Hossain Abu Montakim Tareq Mycal Dutta Talha Bin Emran Jesus Simal-Gandara 《Molecules (Basel, Switzerland)》2021,26(4)
The current study attempted, for the first time, to qualitatively and quantitatively determine the phytochemical components of Elatostema papillosum methanol extract and their biological activities. The present study represents an effort to correlate our previously reported biological activities with a computational study, including molecular docking, and ADME/T (absorption, distribution, metabolism, and excretion/toxicity) analyses, to identify the phytochemicals that are potentially responsible for the antioxidant, antidepressant, anxiolytic, analgesic, and anti-inflammatory activities of this plant. In the gas chromatography-mass spectroscopy analysis, a total of 24 compounds were identified, seven of which were documented as being bioactive based on their binding affinities. These seven were subjected to molecular docking studies that were correlated with the pharmacological outcomes. Additionally, the ADME/T properties of these compounds were evaluated to determine their drug-like properties and toxicity levels. The seven selected, isolated compounds displayed favorable binding affinities to potassium channels, human serotonin receptor, cyclooxygenase-1 (COX-1), COX-2, nuclear factor (NF)-κB, and human peroxiredoxin 5 receptor proteins. Phytol acetate, and terpene compounds identified in E. papillosum displayed strong predictive binding affinities towards the human serotonin receptor. Furthermore, 3-trifluoroacetoxypentadecane showed a significant binding affinity for the KcsA potassium channel. Eicosanal showed the highest predicted binding affinity towards the human peroxiredoxin 5 receptor. All of these findings support the observed in vivo antidepressant and anxiolytic effects and the in vitro antioxidant effects observed for this extract. The identified compounds from E. papillosum showed the lowest binding affinities towards COX-1, COX-2, and NF-κB receptors, which indicated the inconsequential impacts of this extract against the activities of these three proteins. Overall, E. papillosum appears to be bioactive and could represent a potential source for the development of alternative medicines; however, further analytical experiments remain necessary. 相似文献
44.
Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens
Rubal Chahal Arun Nanda Esra Küpeli Akkol Eduardo Sobarzo-Snchez Ashwani Arya Deepak Kaushik Rohit Dutt Rashmi Bhardwaj Md. Habibur Rahman Vineet Mittal 《Molecules (Basel, Switzerland)》2021,26(10)
Ageratum conyzoides L. (Family—Asteraceae) is an annual aromatic invasive herb, mainly distributed over the tropical and subtropical regions of the world. It owns a reputed history of indigenous remedial uses, including as a wound dressing, an antimicrobial, and mouthwash as well as in treatment of dysentery, diarrhea, skin diseases, etc. In this review, the core idea is to present the antifungal potential of the selected medicinal plant and its secondary metabolites against different fungal pathogens. Additionally, toxicological studies (safety profile) conducted on the amazing plant A. conyzoides L. are discussed for the possible clinical development of this medicinal herb. Articles available from 2000 to 2020 were reviewed in detail to exhibit recent appraisals of the antifungal properties of A. conyzoides. Efforts were aimed at delivering evidences for the medicinal application of A. conyzoides by using globally recognized scientific search engines and databases so that an efficient approach for filling the lacunae in the research and development of antifungal drugs can be adopted. After analyzing the literature, it can be reported that the selected medicinal plant effectively suppressed the growth of numerous fungal species, such as Aspergillus, Alternaria, Candida, Fusarium, Phytophthora, and Pythium, owing to the presence of various secondary metabolites, particularly chromenes, terpenoids, flavonoids and coumarins. The possible mechanism of action of different secondary metabolites of the plant against fungal pathogens is also discussed briefly. However, it was found that only a few studies have been performed to demonstrate the plant’s dosage and safety profile in humans. Considered all together, A. conyzoides extract and its constituents may act as a promising biosource for the development of effective antifungal formulations for clinical use. However, in order to establish safety and efficacy, additional scientific research is required to explore chronic toxicological effects of ageratum, to determine the probability of interactions when used with different herbs, and to identify safe dosage. The particulars presented here not only bridge this gap but also furnish future research strategies for the investigators in microbiology, ethno-pharmacology, and drug discovery. 相似文献
45.
Santa Islam Syed Shaheen Shah Prof. Shamsun Naher Dr. Muhammad Ali Ehsan Dr. Md. Abdul Aziz Dr. A. J. Saleh Ahammad 《化学:亚洲杂志》2021,16(22):3516-3543
Dopamine (DA) is an important neurotransmitter, which is created and released from the central nervous system. It plays a crucial role in human activities, like cognition, emotions, and response to anything. Maladjustment of DA in human blood serum results in different neural diseases, like Parkinson's and Schizophrenia. Consequently, researchers have started working on DA detection in blood serum, which is undoubtedly a hot research area. Electrochemical sensing techniques are more promising to detect DA in real samples. However, utilizing conventional electrodes for selective determination of DA encounters numerous problems due to the coexistence of other materials, such as uric acid and ascorbic acid, which have an oxidation potential close to DA. To overcome such problems, researchers have put their focus on the modification of bare electrodes. The aim of this review is to present recent advances in modifications of most used bare electrodes with carbonaceous materials, especially graphene, its derivatives, and carbon nanotubes, for electrochemical detection of DA. A brief discussion about the mechanistic phenomena at the electrode interface has also been included in this review. 相似文献
46.
Dr. Teng Zhang Dr. Yuichi Kitagawa Ryoma Moriake Pedro Paulo Ferreira da Rosa Dr. Md. Jahidul Islam Dr. Tomoki Yoneda Prof. Yasuhide Inokuma Dr. Koji Fushimi Prof. Yasuchika Hasegawa 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(58):14438-14443
In this study, we have demonstrated a two-legged, upright molecular design method for monochromatic and bright red luminescent LnIII-silica nanomaterials. A novel EuIII-silica hybrid nanoparticle was developed by using a doubly binding TPPO−Si(OEt)3 (TPPO: triphenyl phosphine oxide) linker. The TPPO−Si(OEt)3 was confirmed by 1H, 31P, 29Si NMR spectroscopy and single-crystal X-ray analysis. Luminescent Eu(hfa)3 and Eu(tfc)3 moieties (hfa: hexafluoroacetylacetonate, tfc: 3-(trifluoromethylhydroxymethylene)camphorate) were fixed onto TPPO−Si(OEt)3-modified silica nanoparticles, producing Eu(hfa)3(TPPO−Si)2-SiO2 and Eu(tfc)3(TPPO−Si)2-SiO2, respectively. Eu(hfa)3(TPPO−Si)2−SiO2 exhibited the higher intrinsic luminescence quantum yield (93 %) and longer emission lifetime (0.98 ms), which is much larger than those of previously reported EuIII-based hybrid materials. Eu(tfc)3(TPPO−Si)2−SiO2 showed an extra-large intrinsic emission quantum yield (54 %), although the emission quantum yield for the precursor Eu(tfc)3(TPPO−Si(OEt)3)2 was found to be 39 %. These results confirmed that the TPPO−Si(OEt)3 linker is a promising candidate for development of EuIII-based luminescent materials. 相似文献
47.
48.
Md. Nur Alam Miro Antal Alvaro Tejado Theo G. M. van de Ven 《Cellulose (London, England)》2012,19(2):517-522
Chemical reactions in charged nanopores, such as present in cellulose fibers, can be accelerated by adding an inert salt,
that does not participate in the reaction. Due to a Donnan-like equilibrium between ions inside and outside the pores, the
concentration of co-ions in the nanopores (having a charge of the same sign as that of the pore wall), is lower than the concentration
in the bulk. The co-ion concentration in pores can be increased by adding an inert salt, which shifts the Donnan equilibrium.
The increased concentration of reactants in pores results in faster reaction kinetics. Reactions of cellulose with periodate
confirm these predictions. 相似文献
49.
Rehan Zahid Masjuki Bin Haji Hassan Mahendra Varman Riaz Ahmad Mufti Md. Abul Kalam Nurin Wahidah Binti Mohd Zulkifli 《固体与材料科学评论》2017,42(4):267-294
Tribological efficiency of industrial applications involving boundary lubrication regime can be improved to an appreciable extent by the deposition of hard coatings on interacting surfaces. Among such coatings, diamond-like carbon (DLC) coatings are considered to be one of the most suitable ones for the said role. DLC coatings possess a unique combination of physical, chemical, and material properties due to which they can help in minimizing friction-induced energy and material losses even under starved lubrication conditions. Since commercial lubricants are optimized for steel surfaces, therefore, a lot of experimental investigations were carried out to analyze the tribological compatibility of these lubricants with various DLC coatings. However, there is still a lack of understanding about how DLC coatings interact with conventional lubricant additives. Some researchers reported tribologically beneficial interactions between DLC coatings and formulated lubricants while others observed no such behavior. To address these inconsistencies, there is a need to rearrange the published data in a more apprehensible and organized manner with a special emphasis on the mechanisms responsible for a particular tribological behavior. In this way, it can be determined whether synergistic or antagonistic correlation exists between a particular DLC-lubricant combination and research on DLC coatings can be continued in a logical way. In this article, most widely investigated non-doped DLC coatings (ta-C, a-C:H, a-C, and ta-C:H) are tribologically analyzed. Average values of friction and wear coefficients are calculated for various DLC-lubricant combinations using already published data and compared to quantify the effectiveness of a particular lubricant additive in enhancing tribological characteristics of symmetrical non-doped DLC contacts. Moreover, tribological performance parameters of non-doped DLC coatings are compared with those of doped-DLC coatings to understand differences in their tribological behavior in combination with additives. 相似文献
50.
Rosenani A. Haque Abbas Washeel Salman Srinivasa Budagumpi Amirul Al‐Ashraf Abdullah Zena A. Abdul Hameed Al‐Mudaris Amin M. S. Abdul Majid 《应用有机金属化学》2013,27(8):465-473
A series of Ag(I) complexes ( 6 , 7 , 8 , 9 ) derived from imidazol‐2‐ylidenes was synthesized by reacting Ag2O with an o‐, m‐, p‐xylyl or 1,3,5‐triazine‐linked imidazolium salts ( 1 , 2 , 3 , 4 ) and then characterizing these using various spectro‐analytical techniques. Additionally, triazine‐linked bis‐imidazolium salt 5 was characterized using the single‐crystal X‐ray diffraction method. Complexes 6–9 were formed from the N‐heterocyclic carbene ligand precursors 1–3 as PF6‐ salts in good yields. Conversely, salt 5 does not form Ag(I) complex even under various reaction conditions. Using ampicillin as a standard, complexes 6–9 were tested against bacteria strains Escherichia coli and Staphylococcus aureus as Gram‐negative and Gram‐positive bacteria, respectively, showing potent antimicrobial activities against the tested bacteria even at minimum inhibition concentration and bacterial concentration levels. Furthermore, the potential anticancer activities of the reported complexes were evaluated against the human colorectal cancer (HCT 116) cell lines, using 5‐fluorouracil as a standard drug. The highest anticancer activities were observed for complex 8 with an IC50 value of 3.4 μm , whereas the lowest was observed for complex 9 with an IC50 value of 18.1 μm . Copyright © 2013 John Wiley & Sons, Ltd. 相似文献