Evidence for roton creation in a superfluid field emission diode near 0.5 K

The field emission current in Hell near 0.5 K is found to increase rapidly with pressure above above 10 bar. We suggest this may be because an increasing fraction of the current is being carried by ions moving at the Landau critical velocity.     

Magic acid free generation of antiaromatic dications at room temperature

A new method for the generation of dicationic species via ionization of diols is described. The method makes use of milder reagents at room temperatures, an advantage over use of Magic Acid at -78 °C. A series of mono- and dications were synthesized successfully, including previously unattainable species.     

Anion-dependent fluorescence in bis(anilinoethynyl)pyridine derivatives: switchable ON-OFF and OFF-ON responses

Urea and sulfonamide derivatives of 1 exhibit ON-OFF and OFF-ON switchable fluorescent and colorimetric responses upon protonation. The magnitude of the fluorescence event is dictated by the anion, resulting in a rare, fully organic "turn-on" fluorescent sensor for chloride.     

Coarctate versus pericyclic reactivity in naphthalene-fused azo-ene-ynes: synthesis of benzocinnolines and benzoisoindazoles

The cyclization reactions of naphthalene-fused azo-ene-yne compounds are explored both computationally and experimentally. Calculations reveal that naphtho-fusion to an azo-ene-yne scaffold does not significantly alter the transition state energies compared to the benzene-based systems; however, fusing the naphthalene in an angular fashion leads to lower energy intermediates due to the creation of arenes possessing greater aromaticity. Experimentally, the cyclization of the angular systems yields not only the expected monomeric benzocinnolines and benzoisoindazoles, but also several dimeric structures, including one that readily isomerizes in the presence of light and/or trace acid.     

Dynamical inference of hidden biological populations

Population fluctuations in a predator-prey system are analyzed for the case where the number of prey could be determined, subject to measurement noise, but the number of predators was unknown. The problem of how to infer the unmeasured predator dynamics, as well as the model parameters, is addressed. Two solutions are suggested. In the first of these, measurement noise and the dynamical noise in the equation for predator population are neglected; the problem is reduced to a one-dimensional case, and a Bayesian dynamical inference algorithm is employed to reconstruct the model parameters. In the second solution a full-scale Markov Chain Monte Carlo simulation is used to infer both the unknown predator trajectory, and also the model parameters, using the one-dimensional solution as an initial guess.     

Type-II superlattice dual-band LWIR imager with M-barrier and Fabry-Perot resonance

We report a high performance long-wavelength IR dual-band imager based on type-II superlattices with 100% cutoff wavelengths at 9.5 μm (blue channel) and 13 μm (red channel). Test pixels reveal background-limited behavior with specific detectivities as high as ~5×1011 Jones at 7.9 μm in the blue channel and ~1×1011 Jones at 10.2 μm in the red channel at 77 K. These performances were attributed to low dark currents thanks to the M-barrier and Fabry-Perot enhanced quantum efficiencies despite using thin 2 μm absorbing regions. In the imager, the high signal-to-noise ratio contributed to median noise equivalent temperature differences of ~20 milli-Kelvin for both channels with integration times on the order of 0.5 ms, making it suitable for high speed applications.     

Application of pressurized liquid extraction technology to pharmaceutical solid dosage form analysis

The technique of pressurized liquid extraction has been evaluated for the extraction of active ingredients from pharmaceutical dosage forms using montelukast sodium oral chewable tablets as a model. The extraction method was optimized for the number of extraction cycles, extraction time, extraction solvent composition and temperature. Samples were extracted using two cycles of water for 2 min with a cell temperature of 40 degrees C and a pressure of 1.0 x 10(4) kPa, to disintegrate the tablet, followed by three cycles of methanol for 3 min at 70 degrees C and 1.0 x 10(4) kPa, to solubilize montelukast sodium. The method demonstrated an extraction efficiency of 98.2% of label claim and an RSD of 1.3% (n=10), as compared to 97.6% and an RSD of 0.9% obtained using a validated mechanical extraction method.