Attenuation of Scopolamine-Induced Amnesia via Cholinergic Modulation in Mice by Synthetic Curcumin Analogs

Alzheimer’s disease is an emerging health disorder associated with cognitive decline and memory loss. In this study, six curcumin analogs (1a–1f) were synthesized and screened for in vitro cholinesterase inhibitory potential. On the basis of promising results, they were further investigated for in vivo analysis using elevated plus maze (EPM), Y-maze, and novel object recognition (NOR) behavioral models. The binding mode of the synthesized compounds with the active sites of cholinesterases, and the involvement of the cholinergic system in brain hippocampus was determined. The synthesized curcumin analog 1d (p < 0.001, n = 6), and 1c (p < 0.01, n = 6) showed promising results by decreasing retention time in EPM, significantly increasing % SAP in Y-maze, while significantly (p < 0.001) enhancing the % discrimination index (DI) and the time exploring the novel objects in NORT mice behavioral models. A molecular docking study using MOE software was used for validation of the inhibition of cholinesterase(s). It has been indicated from the current research work that the synthesized curcumin analogs enhanced memory functions in mice models and could be used as valuable therapeutic molecules against neurodegenerative disorders. To determine their exact mechanism of action, further studies are suggested.     

Designing of Smooth Composite Panels Providing Stability and Strength at Postbuckling Behavior

Mechanics of Composite Materials - Buckling of skin is admissible for upper load-bearing panels of a wing box and mechanization units of a light aircraft in case of loads close to operating level....     

The Influence of Various Divalent Metal Ions (Mn2+, Co2+, and Cu2+) Substitution on the Structural and Magnetic Properties of Nickel–Zinc Spinel Ferrite

Physics of the Solid State - Ni0.7&nbsp;–&nbsp;xZn0.3MxFe2O4 (M = Mn2+, Co2+, and Cu2+; x = 0, 0.1, 0.3, 0.5, and 0.7) spinel-type ferrite were fabricated through citrate technique....     

Effect of copper addition on some properties of rapidly solidified lead-free Sn–-10 wt% Zn alloys

This study aimed at investigating the effect of adding copper (Cu) on some properties of the lead-free alloys which rapidly solidified from melt. X-ray analysis, hardness, elastic modulus, electrical conductivity and resistivity were studied. The results indicated that the alloy hardness and elastic modulus improved by increasing the copper (Cu) content and decreasing the zinc (Zn) content. The electrical conductivity ranged from 0.250 to 0.847?×?10⁷ ohm^?1 m^?1 for the alloy under study. The electrical resistivity increases linearly with temperature until the melting point is reached. The residual resistivity results from disturbances in the lattice rather than caused by thermal vibration and the most drastic increases in the residual resistivity are caused by foreign atoms in solid solution with matrix metal. The electrical resistivity values ranged from 11.8 to 40?×?10^?8 ohm m, when the copper content changed from 0.0 to 2.0 wt% and zinc changed from 8.0 to 10.0 wt%.     

Fluorescence Screening of Organophosphorus Pesticides in Water by an Enzyme Inhibition Procedure on TLC Plates

JPC – Journal of Planar Chromatography – Modern TLC - An enzymatic inhibition method sufficiently sensitive for rapid screening of seven organophosphorus pesticides in water is...     

3D simulation of radionuclide transport in porous media

We present an efficient and easily implementable finite volume method simulating radionuclide transport through highly heterogeneous grounds in three space dimensions. The numerical concentration of the transported chemicals are proved to remain nonnegative and stable. Then, we run a realistic test case in which some radioactive iodine I¹²⁹ particles are released from a leak in an underground nuclear waste disposal site. The question of whether the radionuclide invades the underground and reach the ground surface is investigated. Because of the 3D nature of the problem, a particular emphasis is made on the control of CPU time. Copyright © 2009 John Wiley & Sons, Ltd.     

Charge carriers and mobility of Cu-Ti ferrite

The concentration and drift mobility of charge carriers in Cu_1–x Ti _x Fe₂O₄ ferrite are calculated, over a wide range of temperatures (300–773 K), employing d.c. conductivity and thermoelectric power data. With increasing temperature the concentration of charge carriers decreases whilst the drift mobility exhibits an exponential increase. Over the above-mentioned temperature range, the obtained density of charge carriers varies between 10²¹ and 10²² cm^–3 whereas the drift mobility has values between 10^–8 and 10^–4 cm²/V s. The results are discussed on the basis of a small-polaron hopping conduction. The activation of the d.c. conductivity has been attributed to the thermal activation of the mobility.