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31.
Targeting the Two Oncogenic Functional Sites of the HPV E6 Oncoprotein with a High‐Affinity Bivalent Ligand
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32.
ortho‐, meta‐, and para‐Dihydroindenofluorene Derivatives as Host Materials for Phosphorescent OLEDs
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Maxime Romain Sébastien Thiery Anna Shirinskaya Dr. Céline Declairieux Dr. Denis Tondelier Bernard Geffroy Dr. Olivier Jeannin Dr. Joëlle Rault‐Berthelot Dr. Rémi Métivier Dr. Cyril Poriel 《Angewandte Chemie (International ed. in English)》2015,54(4):1176-1180
This work reports the first structure–properties relationship study of ortho [2,1‐c]‐, meta [1,2‐a]‐, and para [1,2‐b]dihydroindenofluorenes, highlighting the influence of bridge rigidification on the electronic properties. This study has made it possible to devise an extended π‐conjugated molecule with both a high triplet state energy level and excellent thermal and morphological stability. As a proof of concept, dihydroindenofluorenes were used as the host in sky‐blue phosphorescent organic light‐emitting diodes (PhOLEDs) w ith high performance. 相似文献
33.
34.
Maindron N Poupart S Hamon M Langlois JB Plé N Jean L Romieu A Renard PY 《Organic & biomolecular chemistry》2011,9(7):2357-2370
The synthesis and photo-physical properties of an original bis-pyridinylpyrazine chromophore efficiently sensitising europium(III) and samarium(III) are described. The corresponding lanthanide(III) complexes display in aqueous solutions a maximum excitation wavelength which is significantly red-shifted compared to the usual terpyridine-based chelates, and a valuable luminescence brightness above 2,000 dm(3) mol(-1) cm(-1) at 345 nm was obtained with a europium(III) derivative. Further functionalisation with three different bioconjugatable handles was also investigated and their ability to efficiently label a model hexapeptide was evaluated and compared. Finally, the best bioconjugatable europium(III) chelate was used in representative labelling experiments involving monoclonal antibodies and the luminescence features of the corresponding bioconjugates remained satisfactory. 相似文献
35.
P. Santoro M. Fernández M. Fossati G. Cazes R. TerraI. Piedra-Cueva 《Applied Mathematical Modelling》2011
This paper presents the implementation and calibration of a pre-operational numerical model for the Río de la Plata river. This model is capable of predicting sea level variations in the Río de la Plata, and therefore constitutes a numerical tool of great value for the fluvial–maritime navigation and regional environmental management. A two-dimensional model (MOHID) with nested domains was used to simulate the hydrodynamics. This model was forced with a meso-scale atmospheric model (WRF) and a global tidal model (FES2004). The results obtained include astronomic and meteorological sea level variations in the Río de la Plata. Comparisons of modeled water levels with data have shown very good qualitative and quantitative agreement. The pre-operational test presented in this paper, a 4-day hydrodynamic forecast, was conducted in approximately 18 h. 相似文献
36.
Peterson RL Himes RA Kotani H Suenobu T Tian L Siegler MA Solomon EI Fukuzumi S Karlin KD 《Journal of the American Chemical Society》2011,133(6):1702-1705
The new cupric superoxo complex [LCu(II)(O(2)(?-))](+), which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases. 相似文献
37.
Scerba MT Leavitt CM Diener ME DeBlase AF Guasco TL Siegler MA Bair N Johnson MA Lectka T 《The Journal of organic chemistry》2011,76(19):7975-7984
We report detailed studies on the characterization of an intramolecular NH-F hydrogen bond formed within a fluorinated "proton sponge" derivative. An ammonium ion, generated from 8-fluoro-N,N-dimethylnaphthalen-1-amine, serves as a charged hydrogen bond donor to a covalently bound fluorine appropriately positioned on the naphthalene skeleton. Potentiometric titrations of various N,N-dimethylnaphthalen-1-amines demonstrate a significant increase in basicity when hydrogen bonding is possible. X-ray crystallography reveals that NH-F hydrogen bonding in protonated 8-fluoro-N,N-dimethylnaphthalen-1-amine is heavily influenced by ion pairing in the solid state; bifurcated and trifurcated hydrogen bonds are formed depending on the counterion utilized. Compelling evidence of hydrogen bonding in the 8-fluoro-N,N-dimethylnaphthyl-1-ammonium cation is provided by gas-phase cryogenic vibrational photodissociation spectroscopy. Solution-phase infrared spectroscopy provides complementary results, and the frequencies of the N-H stretching mode in both phases are in excellent agreement with the computed vibrational spectra. NMR analysis of protonated 8-fluoro-N,N-dimethylnaphthalen-1-amine demonstrates significant H-F coupling between the N-H hydrogen and fluorine that cannot be attributed to long-range, through-bond interactions; the couplings correlate favorably with calculated values. The results obtained from these experiments are congruent with the formation of an NH-F hydrogen bond upon protonation of 8-fluoro-N,N-dimethylnaphthalen-1-amine. 相似文献
38.
Boulet-Audet M Vollrath F Holland C 《Physical chemistry chemical physics : PCCP》2011,13(9):3979-3984
Whilst rheology is the reference technique to study the mechanical properties of unspun silk, we know little of the structure and the dynamics that generate them. By coupling infrared spectroscopy and shearing forces to study silk fibroin conversion, we are introducing a novel tool to address this gap in our knowledge. Here the silk conversion process has been studied dynamically using polarized attenuated total reflectance Fourier transform infrared spectroscopy whilst applying shear, thus revealing silk protein conformation and molecular orientation in situ. Our results show that the silk conversion process starts with a pre-alignment of the proteins followed by a rapid growth of the β-sheet formation and then a subsequent deceleration of the growth. We propose that this tool will provide further insight into not only silk but any biopolymer solution, opening a new window into biological materials. 相似文献
39.
Carbon dioxide two-phase flow pressure drops have been investigated in a single horizontal stainless-steel micro-tube having a 0.529 mm inner diameter. Experiments were carried out in adiabatic conditions for four saturation temperatures of −10; −5; 0; 5 °C and mass fluxes ranging from 200 to 1400 kg/m2 s, for inlet qualities up to unity. Measurements have been compared to the predictions of well-known methods. The Müller-Steinhagen and Heck correlation and the Friedel correlation gave the best fit as well as the homogeneous model when the liquid viscosity is used to represent the apparent two-phase viscosity. Further, an analysis based on the homogeneous model has not shown any clear appearance of the laminar or the transition regimes in any given range of Reynolds number. The apparent viscosity of the two-phase mixture was found larger than the liquid viscosity at low vapour qualities, namely at the lowest temperatures. Hence, a new expression to determine the equivalent viscosity was suggested as a function of the reduced pressure. Lastly, the Chisholm parameter from the Lockhart-Martinelli correlation was found lower than expected and also mainly dependent on the saturation temperature. 相似文献
40.
Wolfgang Muessel Helmut Strobel Maxime Joos Eike Nicklas Ion Stroescu Jiří Tomkovič David B. Hume Markus K. Oberthaler 《Applied physics. B, Lasers and optics》2013,113(1):69-73
We report on the optimization of high-intensity absorption imaging for small Bose–Einstein condensates. The imaging calibration exploits the linear scaling of the quantum projection noise with the mean number of atoms for a coherent spin state. After optimization for atomic clouds containing up to 300 atoms, we find an atom number resolution of $\varDelta_{\rm det}= 3.7$ atoms, mainly limited by photon shot noise and radiation pressure. 相似文献