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991.
The 1-oxaspiro[2.5]octane moiety is a common motif in many biologically active spiroepoxide compounds. Stereochemistry plays an important role in the action of these spiroepoxides, since the O-axial C3 epimers are predominantly responsible for biological activity. In view of this, the reactivity of the yeast epoxide hydrolase (YEH) from Rhodotorula glutinis towards both O-axial and O-equatorial C3 epimers of various 1-oxaspiro[2.5]octanes was investigated. O-axial C3 Epimers were hydrolyzed faster than the O-equatorial C3 epimers. The stereochemical preference was greatly dependent on the type of substitution on the cyclohexane ring. The preference of YEH for O-axial C3 epimers, found throughout this study, illustrates the effectiveness of YEH in enzymatic detoxification of spiroepoxides. 相似文献
992.
We present a density-function theory (DFT) study of Bjerrum-defect trapping centers involving the molecular vacancy in ice Ih. As a first step, we compute the intrinsic migration barrier to D-defect motion using the nudged elastic band (NEB) method and find them to be of the same order of magnitude as the energy barriers involving intrinsic L-defect motion. This finding suggests that intrinsic mobility factors cannot explain the experimentally observed inactivity of D defects, supporting the idea that D defects are trapped at other lattice-defect sites. Next we study the defect complexes formed by the combination of isolated D and L defects with a molecular vacancy. The corresponding geometries show that the formation of these aggregates significantly reduces elastic distortions that are present in isolated Bjerrum defects. An analysis of the energetics involved in the formation of both defect complexes reveals a significant binding energy, indicating that the molecular vacancy represents a strong trapping center for Bjerrum defects. On the other hand, the fact that there is no difference between the absolute values of the binding energies for both D and L defects suggests that the vacancy affects both species of Bjerrum defects in a similar fashion, possibly ruling out the vacancy trapping centers as an explanation for the experimentally observed inactivity of D defects. 相似文献
993.
994.
Niklas J Schulte T Prakash S van Gastel M Hofmann E Lubitz W 《Journal of the American Chemical Society》2007,129(50):15442-15443
995.
Jaber F Schummer C Al Chami J Mirabel P Millet M 《Analytical and bioanalytical chemistry》2007,387(7):2527-2535
Solid-phase microextraction (SPME) coupled with gas chromatography–mass spectrometry has been used for analysis of four phenols
and sixteen nitrophenols in rainwater samples. Analytes were extracted from the water in the immersion mode and derivatised
for 5 min during direct desorption in the GC injector. Before desorption, 2 μL N-(t-butyldimethylsilyl)-N-methyltrifluoroacetamide (MDBSTFA) was introduced into the injector, which was maintained at 280 °C. Different conditions
affecting extraction efficiency were studied, including temperature, type of microextraction fibre, and effect of pH and ionic
strength. Five different fibre coatings were tested: 85-μm polyacrylate (PA), 100-μm polydimethylsiloxane (PDMS), 65-μm Carbowax–divinylbenzene
(CW–DVB), 75-μm Carboxen–polydimethylsiloxane (CAR–PDMS), and 65-μm polydimethylsiloxane–divinylbenzene (PDMS–DVB). The best
conditions were use of PA fibres for 40 min at ambient temperature (75 g NaCl per 100 mL, pH 3.0). MDBSTFA was used as derivatising
agent because it enables analysis of phenols derivatives with high confidence in identification, because in electron-impact
mode TBDMS–phenol derivatives produce the specific M–57 ion. Quantification was achieved by using 4-nitrophenol-d4, at 1 mg
L−1, as internal standard. Linearity was good, with correlation coefficients in the range 0.9888 (o-cresol) to 0.9987 (dinitro-o-cresol, DNOC). Detection limits varied between 0.208 and 99.3 μg L−1 and quantification limits between 0.693 and 331 μg L−1. Uncertainties varied between 8.7% (phenol) and 17.9% (4-methyl-2-nitrophenol). The method was successfully applied to the
analysis of rainwater collected at urban and rural sites in Alsace (East of France). Because of derivatisation in the injector
and the associated high temperature, the lifetime of the fibre is severely reduced. 相似文献
996.
997.
998.
999.
van Gastel M Shaw JL Blake AJ Flores M Schröder M McMaster J Lubitz W 《Inorganic chemistry》2008,47(24):11688-11697
The binuclear complex [Ni(2)(L)(MeCN)(2)](3+) (L(2-) = compartmental macrocycle incorporating imine N and thiolate S donors) has a Ni(III) center bridged via two thiolate S-donors to a diamagnetic Ni(II) center. The ground-state has dominant 3d(z)(1)(2) character similar to that observed for [NiFe] hydrogenases in which Ni(III) is bridged via two thiolate donors to a diamagnetic center (Fe(II)). The system has been studied by X-ray crystallography and pulse EPR, ESEEM, and ENDOR spectroscopy in order to determine the extent of spin-delocalization onto the macrocycle L(2-). The hyperfine coupling constants of six nitrogen atoms have been identified and divided into three sets of two equivalent nitrogens. The most strongly coupled nitrogen atoms (a(iso) approximately 53 MHz) stem from axially bound solvent acetonitrile molecules. The two macrocycle nitrogens on the Ni(III) side have a coupling of a(iso) approximately 11 MHz, and those on the Ni(II) side have a coupling of a(iso) approximately 1-2 MHz. Density functional theory (DFT) calculations confirm this assignment, while comparison of the calculated and experimental (14)N hyperfine coupling constants yields a complete picture of the electron-spin density distribution. In total, 91% spin density is found at the Ni(III) of which 72% is in the 3d(z)(2) orbital and 16% in the 3d(xy) orbital. The Ni(II) contains -3.5% spin density, and 7.5% spin density is found at the axial MeCN ligands. In analogy to hydrogenases, it becomes apparent that binding of a substrate to Ni at the axial positions causes a redistribution of the electron charge and spin density, and this redistribution polarizes the chemical bonds of the axial ligand. For [NiFe] hydrogenases this implies that the H(2) bond becomes polarized upon binding of the substrate, which may facilitate its heterolytic splitting. 相似文献
1000.
We present a model for the determination of the thermal equilibrium concentrations of Bjerrum defects, molecular point defects, and their aggregates in ice I(h). First, using a procedure which minimizes the free energy of an ice crystal with respect to the numbers of defect species, we derive a set of equations for the equilibrium concentrations of free Bjerrum and point defects, as well their complexes. Using density-functional-theory calculations, we then evaluate the binding energies of Bjerrum-defect/vacancy and Bjerrum-defect/interstitial complexes. In contrast to the complexes which involve the molecular vacancy, the results suggest that the molecular interstitial binds preferentially to the D-type Bjerrum defect. Using both theoretical binding and formation free energies as well as the available experimental data, we find that the preferential binding and the substantial presence of the interstitial as the predominant point defect in ice I(h) may lead to conditions in which the number of free D defects becomes considerably smaller than that of free L defects. Such a scenario could possibly be involved in the experimentally observed inactivity of D-type Bjerrum defects in the electrical properties of ice I(h). 相似文献