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81.
82.
Maurer HH 《Analytical and bioanalytical chemistry》2009,393(1):97-107
Driving under the influence of prescribed or illegal drugs increases the risk of having road accidents, just like driving
under the influence of alcohol. In forensic toxicology, an increasing number of blood samples must be analyzed for drugs.
Immunoassays tailored for a limited number of drugs (of abuse) are usually applied as prescreening tests at the roadside and/or
in the laboratory. However, many other common drugs, such as anesthetics, antidepressants, antiepileptics, antihistamines,
newer designer drugs, herbal drugs, neuroleptics (antipsychotics), opioids, or sedative-hypnotics, can also impair drivers.
Therefore, this paper reviews multianalyte single-stage and tandem gas or liquid chromatography–mass spectrometry (GC-MS or
LC-MS) procedures for the screening, identification, and validated quantification of such drugs in blood that have been reported
since 2003. Basic information about the biosample assayed, workup, chromatography, the mass spectral detection mode, and validation
data is summarized in tables. The pros and cons of the reviewed procedures are critically discussed, particularly with respect
to their probable usefulness in impaired driving toxicology.
Parts of this review were presented as a plenary lecture at T2007, the joint meeting of the International Council on Alcohol,
Drugs, and Traffic Safety (ICADTS) and The International Association of Forensic Toxicologists (TIAFT), Seattle (WA), August
26–30, 2007. 相似文献
83.
Studies are described on the metabolism and the toxicological detection of the amphetamine-derived designer drug 2,4,5-trimethoxyamphetamine (TMA-2) in rat urine using gas chromatographic/mass spectrometric (GC/MS) techniques. The identified metabolites indicated that TMA-2 was metabolized by oxidative deamination to the corresponding ketone followed by reduction to the corresponding alcohol, O-demethylation followed by oxidative deamination, and finally O,O-bis-demethylation. All metabolites carrying hydroxy groups were found to be partly excreted in urine as glucuronides and/or sulfates. The authors' systematic toxicological analysis (STA) procedure using full-scan GC/MS after acid hydrolysis, liquid-liquid extraction, and microwave-assisted acetylation allowed the detection, in rat urine, of an intake of TMA-2 that corresponds to a common drug users' dose. Assuming similar metabolism, the described STA procedure in human urine should be suitable as proof of an intake of TMA-2. 相似文献
84.
Chen C Nagy G Walker AV Maurer K McShea A Moeller KD 《Journal of the American Chemical Society》2006,128(50):16020-16021
Time-of-flight secondary ion mass spectrometry (TOF SIMS) has been used in conjunction with a mass spectrometry cleavable linker to determine the percent conversion of reactions that were conducted site-selectively on an addressable microelectrode array. When combined with fluorescence techniques for analysis of the reactions, the TOF SIMS experiment provides a means for optimization of both reaction confinement and reaction efficiency on the microelectrode arrays. 相似文献
85.
Molecular dynamics studies have been performed on the zwitterionic form of the dipeptide glycine-alanine in water, with focus on the solvation and electrostatic properties using a range of theoretical methods, from purely classical force fields, through mixed quantum mechanical/molecular mechanical simulations, to fully quantum mechanical Car-Parrinello calculations. The results of these studies show that the solvation pattern is similar for all methods used for most atoms in the dipeptide, but can differ substantially for some groups; namely the carboxy and aminoterminii, and the backbone amid NH group. This might have implications in other theoretical studies of peptides and proteins with charged -NH(3) (+) and -CO(2) (-) side chains solvated in water. Hybrid quantum mechanical/molecular mechanical simulations successfully reproduce the solvation patterns from the fully quantum mechanical simulations (PACS numbers: 87.14.Ee, 87.15.Aa, 87.15.He, 71.15.Pd). 相似文献
86.
Near- and mid-infrared laser-optical sensors for gas analysis 总被引:3,自引:0,他引:3
Peter Werle Franz Slemr Karl Maurer Robert Kormann Robert Mücke Bernd Jnker 《Optics and Lasers in Engineering》2002,37(2-3)
Semiconductor diode lasers were first developed in the mid-1960s and found immediate application as much needed tunable sources for high-resolution laser spectroscopy commonly referred to as tunable diode laser absorption spectroscopy (TDLAS). In this paper, currently available semiconductor lasers for spectroscopy in the near- and mid-infrared spectral region based upon gallium arsenide, indium phosphite, antimonides and lead-salt containing compounds will be reviewed together with the main features of TDLAS. Room-temperature measurements of atmospheric carbon dioxide near 2 μm will be discussed and recent results obtained with a fast chemical sensor for methane flux measurements based on lead-salt diode lasers operating near 7.8 μm will be presented. 相似文献
87.
Signal processing and calibration procedures for in situ diode-laser absorption spectroscopy 总被引:1,自引:0,他引:1
Werle PW Mazzinghi P D'Amato F De Rosa M Maurer K Slemr F 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2004,60(8-9):1685-1705
Gas analyzers based on tunable diode-laser spectroscopy (TDLS) provide high sensitivity, fast response and highly specific in situ measurements of several atmospheric trace gases simultaneously. Under optimum conditions even a shot noise limited performance can be obtained. For field applications outside the laboratory practical limitations are important. At ambient mixing ratios below a few parts-per-billion spectrometers become more and more sensitive towards noise, interference, drift effects and background changes associated with low level signals. It is the purpose of this review to address some of the problems which are encountered at these low levels and to describe a signal processing strategy for trace gas monitoring and a concept for in situ system calibration applicable for tunable diode-laser spectroscopy. To meet the requirement of quality assurance for field measurements and monitoring applications, procedures to check the linearity according to International Standard Organization regulations are described and some measurements of calibration functions are presented and discussed. 相似文献
88.
Schaeublin NM Braydich-Stolle LK Maurer EI Park K MacCuspie RI Afrooz AR Vaia RA Saleh NB Hussain SM 《Langmuir : the ACS journal of surfaces and colloids》2012,28(6):3248-3258
Gold nanomaterials (AuNMs) have distinctive electronic and optical properties, making them ideal candidates for biological, medical, and defense applications. Therefore, it is imperative to evaluate the potential biological impact of AuNMs before employing them in any application. This study investigates two AuNMs with different aspect ratios (AR) on mediation of biological responses in the human keratinocyte cell line (HaCaT) to model potential skin exposure to these AuNMs. The cellular responses were evaluated by cell viability, reactive oxygen species (ROS) generation, alteration in gene and protein expression, and inflammatory response. Gold nanospheres, nominally 20 nm in diameter and coated with mercaptopropane sulfonate (AuNS-MPS), formed agglomerates when dispersed in cell culture media, had a large fractal dimension (D(f) = 2.57 ± 0.4) (i.e., tightly bound and densely packed) and were found to be nontoxic even at the highest dose of 100 μg/mL. Highly uniform, 16.7 nm diameter, and 43.8 nm long polyethylene glycol-capped gold nanorods (AuNR-PEG) also formed agglomerates when dispersed into the cell culture media. However, the agglomerates had a smaller fractal dimension (D(f) = 1.28 ± 0.08) (i.e., loosely bound) and were found to be cytotoxic to the HaCaT cells, with a significant decrease in cell viability occurring at 25 μg/mL and higher. Moreover, AuNR-PEG caused significant ROS production and up-regulated several genes involved in cellular stress and toxicity. These results, combined with increased levels of inflammatory and apoptotic proteins, demonstrated that the AuNR-PEG induced apoptosis. Exposure to AuNS-MPS, however, did not show any of the detrimental effects observed from the AuNR-PEG. Therefore, we conclude that shape appears to play a key role in mediating the cellular response to AuNMs. 相似文献
89.
T Schulz M Leibold C Färber M Maurer T Porsch MC Holthausen U Siemeling 《Chemical communications (Cambridge, England)》2012,48(73):9123-9125
The "Alder carbene" (iPr(2)N)(2)C undergoes a β-fragmentation in solution already at room temperature, affording propene and N,N,N'-triisopropylformamidine. This stands in sharp contrast to the indefinite stability previously claimed for this iconic compound. 相似文献
90.
Sandra Engelskirchen Reinhard Maurer Tatjana LevyRainer Berghaus Helmut AuweterOtto Glatter 《Journal of colloid and interface science》2012,388(1):151-161
Effective plant protection agents are readily available and well implemented in industry. However, delivery to the plant and application on the leaf are processes that still need to be optimized. Up to now plant protection formulations represent either emulsion or suspension concentrates that often contain environmentally harmful organic solvents and/or adjuvants. Emulsified microemulsions are hierarchically organized systems comprising emulsion droplets that confine a water-in-oil microemulsion. In the present contribution we show that emulsified microemulsions prepared from environmentally friendly components can be loaded with the plant-protection agent Fenpropimorph® up to 48 wt.% without organic solvent. The emulsion itself is highly concentrated, containing 60 wt.% of dispersed phase, and can be readily diluted with water for spraying in farming applications. Small-angle X-ray measurements reveal the existence of a water-in-Fenpropimorph® microemulsion confined inside the emulsion droplets. Dynamic light scattering shows that the emulsions prepared are monomodal, comprising droplet radii in the hundred nanometer range. 相似文献