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791.
Lisa Tanzi Davide Rubes Teodora Bavaro Matthieu Sollogoub Massimo Serra Yongmin Zhang Marco Terreni 《Molecules (Basel, Switzerland)》2022,27(9)
In the last few years, nanomaterials based on fullerene have begun to be considered promising tools in the development of efficient adjuvant/delivery systems for vaccination, thanks to their several advantages such as biocompatibility, size, and easy preparation and modification. In this work we reported the chemoenzymatic synthesis of natural polymannan analogues (di- and tri-mannan oligosaccharides characterized by α1,6man and/or α1,2man motifs) endowed with an anomeric propargyl group. These sugar derivatives were submitted to 1,3 Huisgen dipolar cycloaddition with a malondiamide-based chain equipped with two azido terminal groups. The obtained sugar-modified malondiamide derivatives were used to functionalize the surface of Buckminster fullerene (C60) in a highly controlled fashion, and yields (11–41%) higher than those so far reported by employing analogue linkers. The same strategy has been exploited to obtain C60 endowed with natural and unnatural amino acid derivatives. Finally, the first double functionalization of fullerene with both sugar- and amino acid-modified malondiamide chains was successfully performed, paving the way to the possible derivatization of fullerenes with immunogenic sugars and more complex antigenic peptides. 相似文献
792.
Dr. Denis Leshchev Dr. Andrew J. S. Valentine Dr. Pyosang Kim Dr. Alexis W. Mills Dr. Subhangi Roy Dr. Arnab Chakraborty Dr. Elisa Biasin Prof. Kristoffer Haldrup Dr. Darren J. Hsu Dr. Matthew S. Kirschner Dr. Dolev Rimmerman Dr. Matthieu Chollet Dr. J. Michael Glownia Dr. Tim B. van Driel Prof. Felix N. Castellano Prof. Xiaosong Li Prof. Lin X. Chen 《Angewandte Chemie (International ed. in English)》2023,62(28):e202304615
Photoexcited molecular trajectories on potential energy surfaces (PESs) prior to thermalization are intimately connected to the photochemical reaction outcome. The excited-state trajectories of a diplatinum complex featuring photo-activated metal–metal σ-bond formation and associated Pt−Pt stretching motions were detected in real time using femtosecond wide-angle X-ray solution scattering. The observed motions correspond well with coherent vibrational wavepacket motions detected by femtosecond optical transient absorption. Two key coordinates for intersystem crossing have been identified, the Pt−Pt bond length and the orientation of the ligands coordinated with the platinum centers, along which the excited-state trajectories can be projected onto the calculated PESs of the excited states. This investigation has gleaned novel insight into electronic transitions occurring on the time scales of vibrational motions measured in real time, revealing ultrafast nonadiabatic or non-equilibrium processes along excited-state trajectories involving multiple excited-state PESs. 相似文献
793.
The European Physical Journal E - In this study, polyurethane (PU)-based xerogels were synthesized by using the biobased polyol derived from chaulmoogra seed oil. These polyol was used for the... 相似文献
794.
Shiny Maity Brad D. Price C. Blake Wilson Arnab Mukherjee Matthieu Starck David Parker Maxwell Z. Wilson Janet E. Lovett Songi Han Mark S. Sherwin 《Angewandte Chemie (International ed. in English)》2023,62(13):e202212832
We present time-resolved Gd−Gd electron paramagnetic resonance (TiGGER) at 240 GHz for tracking inter-residue distances during a protein's mechanical cycle in the solution state. TiGGER makes use of Gd-sTPATCN spin labels, whose favorable qualities include a spin-7/2 EPR-active center, short linker, narrow intrinsic linewidth, and virtually no anisotropy at high fields (8.6 T) when compared to nitroxide spin labels. Using TiGGER, we determined that upon light activation, the C-terminus and N-terminus of AsLOV2 separate in less than 1 s and relax back to equilibrium with a time constant of approximately 60 s. TiGGER revealed that the light-activated long-range mechanical motion is slowed in the Q513A variant of AsLOV2 and is correlated to the similarly slowed relaxation of the optically excited chromophore as described in recent literature. TiGGER has the potential to valuably complement existing methods for the study of triggered functional dynamics in proteins. 相似文献
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797.
Maxime Robin Stephane Mialhe Valerie Pique Robert Faure Jean‐Pierre Galy 《ChemInform》2002,33(38):153-153