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21.
Hermann Specker Heinrich Hartkamp und Mathilde Kuchtner 《Fresenius' Journal of Analytical Chemistry》1954,143(6):425-431
Zusammenfassung Kleine Mengen Margan können durch Extraktion der innerkomplexen Mangan(III)-dithiocarbaminate mit Chloroform und nachfolgende Photometrierung der braunvioletten Extrakte schnell und genau bestimmt werden. Nur wenige Elemente stören. Sie können vorher durch Extraktion rasch und quantitativ abgetrennt werden. 相似文献
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Summary Three optimized small-scale methods for amino acid separation are described and compared. Two dimensional separations are
based on paper or cellulose thin-layer ionophoresis and chromatography with simple and inexpensive apparatus. The influence
of experimental conditions on resolution and amount required for amino acids possessing almost identical mobilities, is studied.
The quickest procedure based on the coupling of 200×200×0.25 mm thin-layer, low-voltage electrophoresis (20 V/cm) with chromatography,
and the system: cellulose −1.04 mol dm−3 formic acid — tertbutanol/methanol/pyridine/formic acid/water (33∶43∶9.6∶0.4∶20), provides very reproducible results with
high separating power for small samples (2–10 nmoles). 相似文献
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Mathilde Mougeot Karine Tribouley 《Annals of the Institute of Statistical Mathematics》2010,62(2):383-412
We propose a test procedure which compares the extreme value indices of two samples with heavy tail distributions. On a theoretical
point of view, we adopt the minimax nonparametric point of view. We exhibit the separating rate between the null hypothesis
and the alternative of our procedure. Next, we present a data driven test methodology and we evaluate its performance thanks
to an extensive simulation study. As a practical real-life application, we compare the risk behaviors of a panel of different
financial data. 相似文献
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The nature of the 7-substituent has a remarkable effect on the diastereoselectivity of the oxidative rearrangement of indole-2-carboxamides derived from (S)-2-methoxymethylpyrrolidine into chiral 3,3-disubstituted oxindoles. 相似文献
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Wei Duo Orlandi Ezequiel Barriet Mathilde Simon Sébastien Sjöblom Johan 《Journal of Thermal Analysis and Calorimetry》2015,121(1):463-468
Journal of Thermal Analysis and Calorimetry - This paper describes the self-association of tetrameric acids (TA) and their interactions with asphaltenes using isothermal titration calorimetry. In... 相似文献
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Zoltan Dekan Thomas Kremsmayr Peter Keov Mathilde Godin Ngari Teakle Leopold Dürrauer Huang Xiang Dalia Gharib Christian Bergmayr Roland Hellinger Marina Gay Marta Vilaseca Dennis Kurzbach Fernando Albericio Paul F. Alewood Christian W. Gruber Markus Muttenthaler 《Chemical science》2021,12(11):4057
Vasopressin (VP) and oxytocin (OT) are cyclic neuropeptides that regulate fundamental physiological functions via four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR. Ligand development remains challenging for these receptors due to complex structure–activity relationships. Here, we investigated dimerization as a strategy for developing ligands with novel pharmacology. We regioselectively synthesised and systematically studied parallel, antiparallel and N- to C-terminal cyclized homo- and heterodimer constructs of VP, OT and dVDAVP (1-deamino-4-valine-8-d-arginine-VP). All disulfide-linked dimers, except for the head-to-tail cyclized constructs, retained nanomolar potency despite the structural implications of dimerization. Our results support a single chain interaction for receptor activation. Dimer orientation had little impact on activity, except for the dVDAVP homodimers, where an antagonist to agonist switch was observed at the V1aR. This study provides novel insights into the structural requirements of VP/OT receptor activation and spotlights dimerization as a strategy to modulate pharmacology, a concept also frequently observed in nature.Structural and pharmacological study of parallel, antiparallel and N- to C-terminal cyclized homo- and heterodimers of vasopressin and oxytocin. This study spotlights dimerization as a strategy to modulate the pharmacology of neuropeptides. 相似文献