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101.
Najim N Bathich Y Zain MM Hamzah AS Shaameri Z 《Molecules (Basel, Switzerland)》2010,15(12):9340-9353
The aim of this study was to investigate the in vitro cellular activity of novel spiroisoxazoline type compounds against normal and cancer cell lines from lung tissue (Hs888Lu), neuron-phenotypic cells (SH-SY5Y), neuroblastoma (SH-SY5Y), human histiocytic lymphoma (U937), lung cancer (A549), and leukaemia (HL-60). Our bioassay program revealed that the spiroisoxazoline type compounds show cytotoxicity only in lymphoma cell lines, which is in contrast with the pyrrolidine precursor of these spiroisoxazoline compounds, where significant cytotoxicity is seen in all normal and cancer cell lines. These data suggest a tumour-specific mechanism of action. In addition these data also show that spiroisoxazoline compounds are non-toxic in the human neuronphenotypic neuroblastoma SH-SY5Y cell line, and furthermore that they might protect cells from neurodegenerative disease. 相似文献
102.
Gabriela Broncová Sergey Anikin Ulrich Lange Pavel Matějka Martin Krondak Vladimír Král Vladimir M. Mirsky 《Journal of Solid State Electrochemistry》2010,14(6):1035-1044
The structure and the electrochemical and spectral properties of two conductive electrochemically polymerized substituted
bipyrroles 4,4′-methoxy-2,2′-bipyrrole and 4,4′-buthoxy-2,2′-bipyrrole were studied and compared. The polymers were characterized
by cyclic voltammetry, FT-Raman spectroscopy, scanning electron microscopy, and in situ conductivity measurements at different
pH and redox state. 相似文献
103.
Miroslava Trchová Pavel Matějka Andrea Kalendová Jaroslav Stejskal 《Polymer Degradation and Stability》2006,91(1):114-121
Polyaniline base has been exposed to various temperatures between 100 °C and 1000 °C for 2 h in air. The mass loss has increased with increasing temperature. FTIR and Raman spectroscopies show the gradual destruction of the PANI structure, the possible formation of intermediate oxime and nitrile groups, and the final conversion to graphitic material. The elemental analysis confirmed the dehydrogenation while the content of nitrogen was nearly constant even after treatment at 800 °C. The conductivity of PANI base, 10−8 S cm−1, increased to ∼10−4 S cm−1 after treatment at 1000 °C; most of the products, however, were non-conducting. Another series of experiments involved the polyaniline base heated at 500 °C for 1-8 h. The studies were performed in connection with the potential flame-retardant application of polyaniline. 相似文献
104.
[reaction: see text] A new iron(III) halide-promoted aza-Prins cyclization between gamma,delta-unsaturated tosylamines and aldehydes provides six-membered azacycles in good to excellent yields. The process is based on the consecutive generation of gamma-unsaturated-iminium ion and further nucleophilic attack by the unsaturated carbon-carbon bond. Homoallyl tosylamine leads to trans-2-alkyl-4-halo-1-tosylpiperidine as the major isomer. In addition, the alkyne aza-Prins cyclization between homopropargyl tosylamine and aldehydes gives 2-alkyl-4-halo-1-tosyl-1,2,5,6-tetrahydropyridines as the only cyclic products. 相似文献
105.
Matěj Stehlík 《Graphs and Combinatorics》2006,22(3):421-426
A hypergraph is τ-critical if τ(−{E})<τ() for every edge E ∈ , where τ() denotes the transversal number of . We show that if is a connected τ-critical hypergraph, then −{E} can be partitioned into τ()−1 stars of size at least two, for every edge E ∈ . An immediate corollary is that a connected τ-critical hypergraph has at least 2τ()−1 edges. This extends, in a very natural way, a classical theorem of Gallai on colour-critical graphs, and is equivalent
to a theorem of Füredi on t-stable hypergraphs. We deduce a lower bound on the size of τ-critical hypergraphs of minimum degree at least two. 相似文献
106.
Marek Omelka Matías Salibián-Barrera 《Annals of the Institute of Statistical Mathematics》2010,62(5):897-927
In this paper we find verifiable regularity conditions to ensure that S-estimators of scale and regression and MM-estimators
of regression are uniformly consistent and uniformly asymptotically normally distributed over contamination neighbourhoods.
Moreover, we show how to calculate the size of these neighbourhoods. In particular, we find that, for MM-estimators computed
with Tukey’s family of bisquare score functions, there is a trade-off between the size of these neighbourhoods and both the
breakdown point of the S-estimators and the leverage of the contamination that is allowed in the neighbourhood. These results
extend previous work of Salibian-Barrera and Zamar for location-scale to the linear regression model. 相似文献
107.
Kazem Naghavi Elias Saion Khadijeh Rezaee Wan Mahmood Mat Yunus 《Radiation Physics and Chemistry》2010,79(12):1203-1208
Colloidal silver nanoparticles were synthesized by γ-irradiation-induced reduction method of an aqueous solution containing silver nitrate as a precursor in various concentrations between 7.40×10?4 and 1.84×10?3 M, polyvinyl pyrrolidone for capping colloidal nanoparticles, isopropanol as radical scavenger of hydroxyl radicals and deionised water as a solvent. The irradiations were carried out in a 60Co γ source chamber at doses up to 70 kGy. The optical absorption spectra were measured using UV–vis spectrophotometer and used to study the particle distribution and electronic structure of silver nanoparticles. As the radiation dose increases from 10 to 70 kGy, the absorption intensity increases with increasing dose. The absorption peak λmax blue shifted from 410 to 403 nm correspond to the increase of absorption conduction electron energy from 3.02 to 3.08 eV, indicating the particle size decreases with increasing dose. The particle size was determined by photon cross correlation spectroscopy and the results showed that the particle diameter decreases exponentially with the increase of dose. The transmission electron microscopy images were taken at doses of 20 and 60 kGy and the results confirmed that as the dose increases the diameter of colloidal silver nanoparticle decreases and the particle distribution increases. 相似文献
108.
Optical nonuniformities in the nuclear-pumped gas lasers are calculated. The nonuniformities are formed due to inhomogeneous energy deposition by the fission fragments from thin plane uranium layers that irradiate the laser active gas. The results of calculations agree with experimental data. 相似文献
109.
110.
Farrah Syazana Khattulanuar Mahendran Sekar Shivkanya Fuloria Siew Hua Gan Nur Najihah Izzati Mat Rani Subban Ravi Kumarappan Chidambaram M. Yasmin Begum Abul Kalam Azad Srikanth Jeyabalan Arulmozhi Dhiravidamani Lakshmi Thangavelu Pei Teng Lum Vetriselvan Subramaniyan Yuan Seng Wu Kathiresan V. Sathasivam Neeraj Kumar Fuloria 《Molecules (Basel, Switzerland)》2022,27(3)
Cardiovascular disorders (CVDs) are the leading risk factor for death worldwide, and research into the processes and treatment regimens has received a lot of attention. Tilianin is a flavonoid glycoside that can be found in a wide range of medicinal plants and is most commonly obtained from Dracocephalum moldavica. Due to its extensive range of biological actions, it has become a well-known molecule in recent years. In particular, numerous studies have shown that tilianin has cardioprotective properties against CVDs. Hence, this review summarises tilianin’s preclinical research in CVDs, as well as its mechanism of action and opportunities in future drug development. The physicochemical and drug-likeness properties, as well as the toxicity profile, were also highlighted. Tilianin can be a natural lead molecule in the therapy of CVDs such as coronary heart disease, angina pectoris, hypertension, and myocardial ischemia, according to scientific evidence. Free radical scavenging, inflammation control, mitochondrial function regulation, and related signalling pathways are all thought to play a role in tilianin’s cardioprotective actions. Finally, we discuss tilianin-derived compounds, as well as the limitations and opportunities of using tilianin as a lead molecule in drug development for CVDs. Overall, the scientific evidence presented in this review supports that tilianin and its derivatives could be used as a lead molecule in CVD drug development initiatives. 相似文献