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排序方式: 共有1614条查询结果,搜索用时 31 毫秒
991.
Andrea Spinaci Catia Lambertucci Michela Buccioni Diego Dal Ben Claudia Graiff Maria Cristina Barbalace Silvana Hrelia Cristina Angeloni Seyed Khosrow Tayebati Massimo Ubaldi Alessio Masi Karl-Norbert Klotz Rosaria Volpini Gabriella Marucci 《Molecules (Basel, Switzerland)》2022,27(8)
The A2A adenosine receptor (A2AAR) is one of the four subtypes activated by nucleoside adenosine, and the molecules able to selectively counteract its action are attractive tools for neurodegenerative disorders. In order to find novel A2AAR ligands, two series of compounds based on purine and triazolotriazine scaffolds were synthesized and tested at ARs. Compound 13 was also tested in an in vitro model of neuroinflammation. Some compounds were found to possess high affinity for A2AAR, and it was observed that compound 13 exerted anti-inflammatory properties in microglial cells. Molecular modeling studies results were in good agreement with the binding affinity data and underlined that triazolotriazine and purine scaffolds are interchangeable only when 5- and 2-positions of the triazolotriazine moiety (corresponding to the purine 2- and 8-positions) are substituted. 相似文献
992.
Manuele Gori Sara Maria Giannitelli Gianluca Vadal Rocco Papalia Loredana Zollo Massimo Sanchez Marcella Trombetta Alberto Rainer Giovanni Di Pino Vincenzo Denaro 《Molecules (Basel, Switzerland)》2022,27(10)
Invasive intraneural electrodes can control advanced neural-interfaced prostheses in human amputees. Nevertheless, in chronic implants, the progressive formation of a fibrotic capsule can gradually isolate the electrode surface from the surrounding tissue leading to loss of functionality. This is due to a nonspecific inflammatory response called foreign-body reaction (FBR). The commonly used poly(ethylene glycol) (PEG)-based low-fouling coatings of implantable devices can be easily encapsulated and are susceptible to oxidative damage in long-term in vivo applications. Recently, sulfobetaine-based zwitterionic hydrogels have emerged as an important class of robust ultra-low fouling biomaterials, holding great potential to mitigate FBR. The aim of this proof-of-principle in vitro work was to assess whether the organic zwitterionic—poly(sulfobetaine methacrylate) [poly(SBMA)]—hydrogel could be a suitable coating for Polyimide (PI)-based intraneural electrodes to reduce FBR. We first synthesized and analyzed the hydrogel through a mechanical characterization (i.e., Young’s modulus). Then, we demonstrated reduced adhesion and activation of fibrogenic and pro-inflammatory cells (i.e., human myofibroblasts and macrophages) on the hydrogel compared with PEG-coated and polystyrene surfaces using cell viability assays, confocal fluorescence microscopy and high-content analysis of oxidative stress production. Interestingly, we successfully coated PI surfaces with a thin film of the hydrogel through covalent bond and demonstrated its high hydrophilicity via water contact angle measurement. Importantly, we showed the long-term release of an anti-fibrotic drug (i.e., Everolimus) from the hydrogel. Because of the low stiffness, biocompatibility, high hydration and ultra-low fouling characteristics, our zwitterionic hydrogel could be envisioned as long-term diffusion-based delivery system for slow and controlled anti-inflammatory and anti-fibrotic drug release in vivo. 相似文献
993.
Marco Bonechi Walter Giurlani Massimo Innocenti Dario Pasini Suryakant Mishra Roberto Giovanardi Claudio Fontanesi 《Molecules (Basel, Switzerland)》2022,27(14)
This paper studies the mechanism of electrochemically induced carbon–bromine dissociation in 1-Br-2-methylnaphalene in the reduction regime. In particular, the bond dissociation of the relevant radical anion is disassembled at a molecular level, exploiting quantum mechanical calculations including steady-state, equilibrium and dissociation dynamics via dynamic reaction coordinate (DRC) calculations. DRC is a molecular-dynamic-based calculation relying on an ab initio potential surface. This is to achieve a detailed picture of the dissociation process in an elementary molecular detail. From a thermodynamic point of view, all the reaction paths examined are energetically feasible. The obtained results suggest that the carbon halogen bond dissociates following the first electron uptake follow a stepwise mechanism. Indeed, the formation of the bromide anion and an organic radical occurs. The latter reacts to form a binaphthalene intrinsically chiral dimer. This paper is respectfully dedicated to Professors Anny Jutand and Christian Amatore for their outstanding contribution in the field of electrochemical catalysis and electrosynthesis. 相似文献
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995.
Benevieri Pierluigi Calamai Alessandro Furi Massimo Pera Maria Patrizia 《Journal of Dynamics and Differential Equations》2022,34(1):555-581
We extend to the infinite dimensional context the link between two completely different topics recently highlighted by the authors: the classical eigenvalue problem for real square matrices and the Brouwer degree for maps between oriented finite dimensional real manifolds. Thanks to this extension, we solve a conjecture regarding global continuation in nonlinear spectral theory that we have formulated in a recent article. Our result (the ex conjecture) is applied to prove a Rabinowitz type global continuation property of the solutions to a perturbed motion equation containing an air resistance frictional force.
相似文献996.
Roberta Macrì Vincenzo Musolino Micaela Gliozzi Cristina Carresi Jessica Maiuolo Saverio Nucera Miriam Scicchitano Francesca Bosco Federica Scarano Stefano Ruga Maria Caterina Zito Lorenza Guarnieri Ezio Bombardelli Vincenzo Mollace 《Molecules (Basel, Switzerland)》2020,25(23)
The employment studies of natural extracts in the prevention and treatment of several diseases highlighted the role of different species of genus Ferula L., belonging to the Apiaceae family, dicotyledonous plants present in many temperate zones of our planet. Ferula communis L. is the main source of sesquiterpene ferutinin, a bioactive compound studied both in vitro and in vivo, because of different effects, such as phytoestrogenic, antioxidant, anti-inflammatory, but also antiproliferative and cytotoxic activity, performed in a dose-dependent and cell-dependent way. The present review will focus on the molecular mechanisms involved in the different activities of Ferutinin, starting from its antioxidant potential at low doses until its ionophoric property and the subsequent mitochondrial dysfunction induced through administration of high doses, which represent the key point of its anticancer action. Furthermore, we will summarize the data acquired from some experimental studies on different cell types and on several diseases. The results obtained showed an important antioxidant and phytoestrogenic regulation with lack of typical side effects related to estrogenic therapy. The preferential cell death induction for tumor cell lines suggests that ferutinin may have anti-neoplastic properties, and may be used as an antiproliferative and cytotoxic agent in an estrogen dependent and independent manner. Nevertheless, more data are needed to clearly understand the effect of ferutinin in animals before using it as a phytoestrogen or anticancer drug. 相似文献
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