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991.
A color changeable optode for thallium(III) ions in aqueous solutions was prepared by physical inclusion of 4-(2-pyridylazo)-resorcinol into a plasticized PVC film. The increase in the absorbance of the optode at 524 nm is proportional to thallium(III) concentration. Different parameters effecting the sensitivity such as sample parameters and composition of the membrane were optimized. The response times of the prepared test-system are found to be 230, 210, and 180 s for 4.8 × 10?6, 4.8 × 10?5, and 4.8 × 10?4 M Tl(III), respectively. The analytical performance of the optode was evaluated, obtaining a linear concentration range of two decades of concentration, 3.1 × 10?6 ? 4.7 × 10?4 M Tl(III), with a limit of detection of 1.8 × 10?6 M Tl(III). Selectivity of the optode is also studied. Application of the optode to the determination of Tl(III) in some aqueous samples yields good results. 相似文献
992.
James H Campbell Tuan Hoang Masoud Jelokhani-Niaraki Matthew D Smith 《BMC biochemistry》2014,15(1):1-9
Background
We have previously shown that the P. gingivalis HmuY hemophore-like protein binds heme and scavenges heme from host hemoproteins to further deliver it to the cognate heme receptor HmuR. The aim of this study was to characterize structural features of HmuY variants in the presence and absence of heme with respect to roles of tryptophan residues in conformational stability.Results
HmuY possesses tryptophan residues at positions 51 and 73, which are conserved in HmuY homologs present in a variety of bacteria, and a tryptophan residue at position 161, which has been found only in HmuY identified in P. gingivalis strains. We expressed and purified the wildtype HmuY and its protein variants with single tryptophan residues replaced by alanine or tyrosine residues. All HmuY variants were subjected to thermal denaturation and fluorescence spectroscopy analyses. Replacement of the most buried W161 only moderately affects protein stability. The most profound effect of the lack of a large hydrophobic side chain in respect to thermal stability is observed for W73. Also replacement of the W51 exposed on the surface results in the greatest loss of protein stability and even the large aromatic side chain of a tyrosine residue has little potential to substitute this tryptophan residue. Heme binding leads to different exposure of the tryptophan residue at position 51 to the surface of the protein. Differences in structural stability of HmuY variants suggest the change of the tertiary structure of the protein upon heme binding.Conclusions
Here we demonstrate differential roles of tryptophan residues in the protein conformational stability. We also propose different conformations of apo- and holoHmuY caused by tertiary changes which allow heme binding to the protein. 相似文献993.
Jouyban A Azarmir O Mirzaei S Hassanzadeh D Ghafourian T Acree WE Nokhodchi A 《Chemical & pharmaceutical bulletin》2008,56(4):602-606
The solubility of paracetamol in water-ethanol-propylene glycol binary and ternary mixtures at 25 and 30 degrees C was determined using flask shake method. The generated data extended the solubility database for further computational investigations and also was used to assess the prediction capability of the Jouyban-Acree model. A new version of the model was proposed for modeling the solubility data in water-cosolvent mixtures with the cosolvent concentration of <50% which is required in pharmaceutical formulations. The accuracy of the predicted solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental solubilities. The overall MPD of the Jouyban-Acree model and the log-linear model of Yalkowsky for the entire composition range of the cosolvents were 11.0+/-8.7 and 55.4+/-17.8%, respectively; the corresponding values for the predicted solubilities in mixtures having a cosolvent concentration of <50% were 12.0+/-9.1 and 22.0+/-11.0%. 相似文献
994.
The binuclear complex [Pt2Me2(ppy)2(mu-dppf)], 1, in which ppy = deprotonated 2-phenylpyridyl and dppf = 1,1'-bis(diphenylphosphino)ferrocene, was synthesized by the reaction of [PtMe(SMe2)(ppy)] with 0.5 equiv of dppf at room temperature. In this reaction when 1 equiv of dppf was used, the dppf chelating complex 2, [PtMe(dppf)(ppy-kappa1C)], was obtained. The reaction of Pt(II)-Pt(II) complex 1 with excess MeI gave the Pt(IV)-Pt(IV) complex [Pt2I2Me4(ppy)2(mu-dppf)], 3. When the reaction was performed with 1 equiv of MeI, a mixture containing unreacted complex 1, a mixed-valence Pt(II)-Pt(IV) complex [PtMe(ppy)(mu-dppf)PtIMe2(ppy)], 4, and complex 3 was obtained. In a comparative study, the reaction of [PtMe(SMe2)(ppy)] with 1 equiv of monodentate phosphine PPh3 gave [PtMe(ppy)(PPh3)], A. MeI was reacted with A to give the platinum(IV) complex [PtMe2I(ppy)(PPh3)], C. All the complexes were fully characterized using multinuclear (1H, 31P, 13C, and 195Pt) NMR spectroscopy, and complex 2 was further identified by single crystal X-ray structure determination. The reaction of binuclear Pt(II)-Pt(II) complex 1 with excess MeI was monitored by low temperature 31P NMR spectroscopy and further by 1H NMR spectroscopy, and the kinetics of the reaction was studied by UV-vis spectroscopy. On the basis of the data, a mechanism has been suggested for the reaction which overall involved stepwise oxidative addition of MeI to the two Pt(II) centers. In this suggested mechanism, the reaction proceeded through a number of Pt(II)-Pt(IV) and Pt(IV)-Pt(IV) intermediates. Although MeI in each step was trans oxidatively added to one of the Pt(II) centers, further trans to cis isomerizations of Me and I groups were also identified. A comparative kinetic study of the reaction of monomeric platinum(II) complex A with MeI was also performed. The rate of reaction of MeI with complex 1 was some 3.5 times faster than that with complex A, indicating that dppf in the complex 1, as compared with PPh 3 in the complex A, has significantly enhanced the electron richness of the platinum centers. 相似文献
995.
Gazaleh Imani Shakibaei Hamid Reza Khavasi Peiman Mirzaei Ayoob Bazgir 《Journal of heterocyclic chemistry》2008,45(5):1481-1484
996.
Masoud Nasr‐Esfahani Bahador Karami Morteza Montazerozohori Karim Abdi 《Journal of heterocyclic chemistry》2008,45(4):1183-1185
997.
Issa Yavari Anvar Mirzaei Loghman Moradi Nargess Hosseini 《Tetrahedron letters》2008,49(15):2355-2358
The 1:1 intermediate generated by the addition of quinoline to dialkyl acetylenedicarboxylates is trapped by 1,3-indanedione to yield dialkyl 3-spiroindanedione-1,2,3,3a-tetrahydropyrrolo[1,2-a]quinoline-1,2-dicarboxylates in good yields. The structures of these products were confirmed by NMR and single-crystal X-ray diffraction studies. 相似文献
998.
Three dimeric cis-dioxomolybdenum(VI) complexes of bis-bidentate Schiff base derivatives containing aromatic nitrogen–nitrogen linkers (4,4′-diaminodiphenylmethane;
4,4′-diaminodiphenylether; 4,4′-diaminodiphenylsulfone) with 2-hydroxy-1-naphthaldehyde have been synthesised and characterized
by physico-chemical and spectroscopic methods. The catalytic activities of the complexes with respect to alkene epoxidation
using tert-butylhydroperoxide (TBHP) as oxidant have been studied. The addition of single wall nanotubes can enhance the catalytic activities
of the Mo complexes and the selectivity of epoxide formation. 相似文献
999.
Masoud Salavati-Niasari Shahrzad Abdolmohammadi 《Journal of inclusion phenomena and macrocyclic chemistry》2008,60(1-2):145-152
Ni(II) complexes of [12]aneN4: 1,4,7,10-tetraazacyclododecane-2,3,8,9-tetraone; [14]aneN4: 1,4,8,11-tetraazacyclotetradecane-2,3,9,10-tetraone; Bzo2[12]aneN4: dibenzo-1,4,7,10-tetraazacyclododecane-2,3,8,9-tetraone and Bzo2[14]aneN4: dibenzo-1,4,8,11-tetraazacyclotetradecane-2,3,9,10-tetraone have been encapsulated in the nanopores of zeolite-Y by a two-step process in the liquid phase: (i) adsorption of [bis(diamine)nickel(II)]; [Ni(N–N)2]–NaY; in the supercages of the zeolite, and (ii) in situ condensation of the nickel(II) precursor complex with diethyloxalate. The new host-guest nanocatalyst (HGN) were characterized by several techniques: chemical analysis and spectroscopic methods (FT-IR, UV/Vis, XRD, BET, DRS) and then were used for oxidation of cyclohexene with molecular oxygen. 相似文献
1000.
Hassan H. Hammud Kamal H. Bouhadir Mamdouh S. Masoud Amer M. Ghannoum Sulaf A. Assi 《Journal of solution chemistry》2008,37(7):895-917
The absorption and emission spectra of six purine derivatives: adenine (I), N(9)-hydroxyethyladenine (II), N(6)-acetyladenine (III), N(6)-isobutyryladenine (IV), guanine (V), and N(2),N(9)-diacetylguanine (VI) have been investigated. The effects of solvent and pH on the positions of λ
max (absorption) and λ
max (emission) of these compounds were determined. Correlations between the absorption wavelength (λ
max ) of these organic compounds and the solvent parameters (D,n,E) or (K,M,N) show that the peak position is affected mainly by specific- and non-specific types of interactions between the solvent and
solute. Solvent effects on the electronic absorption band shifts are indicative of the extent of charge reorganization of
the solute molecules upon electronic excitation. The Stokes shift (ν
abs−ν
em) was correlated with the orientation polarizability (Δf) and was found to depend mainly on the dielectric constant and the refractive index of the solvents. This shift reflects
the influence of the equilibrium solvent arrangement around the excited solute molecule, which rearranges inertially due to
the instantaneous charge redistribution upon radiative deactivation to the electronic ground state. A spectrofluorometric
analysis technique was applied for the quantitative analysis of the components of a ternary mixture of compounds (I–III). 相似文献